Orai channels in proliferation, invasion, and chemoresistance of tumor cells

Calcium signaling via store-operated calcium entry (SOCE) is critical for cellular functions implicated in cancer progression. Alterations in Orai channel isoforms, particularly Orai1 and Orai3, modulate SOCE and influence tumor cell proliferation, invasion, and survival. Here, we review and synthes...

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Detalles Bibliográficos
Autores: Jardín, Isaac, Macías-Diaz, Álvaro, Jiménez-Velarde, Vanesa, Smani, Tarik, Rosado, Juan A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::be3865030b6e284b42a45808473d6369
Acceso en línea:http://hdl.handle.net/10261/432030
https://api.elsevier.com/content/abstract/scopus_id/105029583416
Access Level:acceso abierto
Palabra clave:Orai channels
Cancer
Chemoresistance
Store-operated Ca2+ entry
Tumor progression
Descripción
Sumario:Calcium signaling via store-operated calcium entry (SOCE) is critical for cellular functions implicated in cancer progression. Alterations in Orai channel isoforms, particularly Orai1 and Orai3, modulate SOCE and influence tumor cell proliferation, invasion, and survival. Here, we review and synthesize current evidence showing how Orai1 and Orai3 isoforms modulate oncogenic calcium signals through pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt, ERK1/2, and NF-κB, contributing to tumor progression and chemoresistance by regulating apoptosis, autophagy, and oxidative stress responses. This isoform-specific remodeling enables tumor cells to adapt to therapeutic challenges and oxidative environments. Emerging data suggest that modulating Orai channel function and isoform composition may sensitize some cancer cells to apoptosis and attenuate invasive behavior, at least in specific experimental models. Taken together, available studies support a role for Orai channels as important regulators of tumor-associated Ca2+ signaling and highlight their potential as context-dependent targets to modulate survival and invasive behavior in cancer models.