Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge

These are definitively exciting times for membrane lipid researchers. Once considered just as the cell membrane building blocks, the important role these lipids play is steadily being acknowledged. The improvement occurred in mass spectrometry techniques (MS) allows the establishment of the precise...

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Detalhes bibliográficos
Autores: Barceló-Coblijn, Gwendolyn, Fernández, José Andrés
Tipo de documento: artigo
Data de publicação:2015
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositório:Docusalut
Idioma:inglês
OAI Identifier:oai:docusalut.com:20.500.13003/10966
Acesso em linha:https://hdl.handle.net/20.500.13003/10966
Access Level:Acceso aberto
Palavra-chave:mass spectrometry (MS)
Lipid imaging
MALDI Imaging
SIMS
DESI imaging
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spelling Mass spectrometry coupled to imaging techniques: the better the view the greater the challengeBarceló-Coblijn, GwendolynFernández, José Andrésmass spectrometry (MS)Lipid imagingMALDI ImagingSIMSDESI imagingThese are definitively exciting times for membrane lipid researchers. Once considered just as the cell membrane building blocks, the important role these lipids play is steadily being acknowledged. The improvement occurred in mass spectrometry techniques (MS) allows the establishment of the precise lipid composition of biological extracts. However, to fully understand the biological function of each individual lipid species, we need to know its spatial distribution and dynamics. In the past 10 years, the field has experienced a profound revolution thanks to the development of MS-based techniques allowing lipid imaging (MSI). Images reveal and verify what many lipid researchers had already shown by different means, but none as convincing as an image: each cell type presents a specific lipid composition, which is highly sensitive to its physiological and pathological state. While these techniques will help to place membrane lipids in the position they deserve, they also open the black box containing all the unknown regulatory mechanisms accounting for such tailored lipid composition. Thus, these results urges to different disciplines to redefine their paradigm of study by including the complexity revealed by the MSI techniques.Frontiers Media Sa20152015-01-2220152015-01-22research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/10966reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/109662026-06-22T12:44:07Z
dc.title.none.fl_str_mv Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
title Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
spellingShingle Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
Barceló-Coblijn, Gwendolyn
mass spectrometry (MS)
Lipid imaging
MALDI Imaging
SIMS
DESI imaging
title_short Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
title_full Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
title_fullStr Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
title_full_unstemmed Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
title_sort Mass spectrometry coupled to imaging techniques: the better the view the greater the challenge
dc.creator.none.fl_str_mv Barceló-Coblijn, Gwendolyn
Fernández, José Andrés
author Barceló-Coblijn, Gwendolyn
author_facet Barceló-Coblijn, Gwendolyn
Fernández, José Andrés
author_role author
author2 Fernández, José Andrés
author2_role author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv mass spectrometry (MS)
Lipid imaging
MALDI Imaging
SIMS
DESI imaging
topic mass spectrometry (MS)
Lipid imaging
MALDI Imaging
SIMS
DESI imaging
description These are definitively exciting times for membrane lipid researchers. Once considered just as the cell membrane building blocks, the important role these lipids play is steadily being acknowledged. The improvement occurred in mass spectrometry techniques (MS) allows the establishment of the precise lipid composition of biological extracts. However, to fully understand the biological function of each individual lipid species, we need to know its spatial distribution and dynamics. In the past 10 years, the field has experienced a profound revolution thanks to the development of MS-based techniques allowing lipid imaging (MSI). Images reveal and verify what many lipid researchers had already shown by different means, but none as convincing as an image: each cell type presents a specific lipid composition, which is highly sensitive to its physiological and pathological state. While these techniques will help to place membrane lipids in the position they deserve, they also open the black box containing all the unknown regulatory mechanisms accounting for such tailored lipid composition. Thus, these results urges to different disciplines to redefine their paradigm of study by including the complexity revealed by the MSI techniques.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-22
2015
2015-01-22
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/10966
url https://hdl.handle.net/20.500.13003/10966
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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