Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows th...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/57892 |
| Acceso en línea: | http://hdl.handle.net/10017/57892 https://dx.doi.org/10.1002/ejoc.202300535 |
| Access Level: | acceso abierto |
| Palabra clave: | Química Chemistry |
| Sumario: | Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows the access to a broad range of alfa-hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process. |
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