Skin microdialysis: methods, applications and future opportunities-an EAACI position paper

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being ava...

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Autores: Baumann, Katrine Y., Church, Martin K., Clough, Geraldine F., Quist, Sven Roy, Schmelz, Martin, Skov, Per Stahl, Anderson, Christopher D., Tannert, Line Kring, Giménez Arnau, Anna Maria, Frischbutter, Stefan, Schefel, Jörg, Maurer, Marcus
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/42997
Acceso en línea:http://hdl.handle.net/10230/42997
http://dx.doi.org/10.1186/s13601-019-0262-y
Access Level:acceso abierto
Palabra clave:Cutaneous
Dermal
Inflammation
Interstitial
Microdialysis
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spelling Skin microdialysis: methods, applications and future opportunities-an EAACI position paperBaumann, Katrine Y.Church, Martin K.Clough, Geraldine F.Quist, Sven RoySchmelz, MartinSkov, Per StahlAnderson, Christopher D.Tannert, Line KringGiménez Arnau, Anna MariaFrischbutter, StefanSchefel, JörgMaurer, MarcusCutaneousDermalInflammationInterstitialMicrodialysisSkin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo.BioMed Central201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42997http://dx.doi.org/10.1186/s13601-019-0262-yreponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésClinical and Translational Allergy. 2019 Apr 10;9:24Copyright © The Author(s) 2019. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/429972026-06-12T07:21:37Z
dc.title.none.fl_str_mv Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
title Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
spellingShingle Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
Baumann, Katrine Y.
Cutaneous
Dermal
Inflammation
Interstitial
Microdialysis
title_short Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
title_full Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
title_fullStr Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
title_full_unstemmed Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
title_sort Skin microdialysis: methods, applications and future opportunities-an EAACI position paper
dc.creator.none.fl_str_mv Baumann, Katrine Y.
Church, Martin K.
Clough, Geraldine F.
Quist, Sven Roy
Schmelz, Martin
Skov, Per Stahl
Anderson, Christopher D.
Tannert, Line Kring
Giménez Arnau, Anna Maria
Frischbutter, Stefan
Schefel, Jörg
Maurer, Marcus
author Baumann, Katrine Y.
author_facet Baumann, Katrine Y.
Church, Martin K.
Clough, Geraldine F.
Quist, Sven Roy
Schmelz, Martin
Skov, Per Stahl
Anderson, Christopher D.
Tannert, Line Kring
Giménez Arnau, Anna Maria
Frischbutter, Stefan
Schefel, Jörg
Maurer, Marcus
author_role author
author2 Church, Martin K.
Clough, Geraldine F.
Quist, Sven Roy
Schmelz, Martin
Skov, Per Stahl
Anderson, Christopher D.
Tannert, Line Kring
Giménez Arnau, Anna Maria
Frischbutter, Stefan
Schefel, Jörg
Maurer, Marcus
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cutaneous
Dermal
Inflammation
Interstitial
Microdialysis
topic Cutaneous
Dermal
Inflammation
Interstitial
Microdialysis
description Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position paper from the task force provides an overview of the current use of SMD in the investigation of the pathogenesis of chronic inflammatory skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis, and in studies of cutaneous events during type 1 hypersensitivity reactions. Furthermore, this paper covers drug hypersensitivity, UVB-induced- and neurogenic inflammation, and drug penetration investigated by SMD. The aim of this paper is to encourage the use of SMD and to make the technique easily accessible by providing an overview of methodology and applications, supported by standardized operating procedures for SMD in vivo and ex vivo.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42997
http://dx.doi.org/10.1186/s13601-019-0262-y
url http://hdl.handle.net/10230/42997
http://dx.doi.org/10.1186/s13601-019-0262-y
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical and Translational Allergy. 2019 Apr 10;9:24
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
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