First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale

Den Hond, Elly; Govarts, Eva; Willems, Hanny; Smolders, Roel; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Seiwert, Margarete; Fiddicke, Ulrike; Castaño, Argelia; Esteban-Lopez, Marta; Angerer, Jürgen; Koch, Holger M; Schindler, Birgit K; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Horvat, Milena; Knudsen, Lisbeth E; Joas, Anke; Joas, Reinhard; Biot, Pierre; Aerts, Dominique; Koppen, Gudrun; Katsonouri, Andromachi; Hadjipanayis, Adamos; Krskova, Andrea; Maly, Marek; Mørck, Thit A; Rudnai, Peter; Középesy, Szilvia; Mulcahy, Maurice; Mannion, Rory; Gutleb, Arno C; Fischer, Marc E; Ligocka, Danuta; Jakubowski, Marek; Reis, M Fátima; Namorado, Sónia; Gurzau, Anca Elena; Lupsa, Ioana-Rodica; Halzlova, Katarina; Jajcaj, Michal; Mazej, Darja; Tratnik, Janja Snoj; Lopez-Herranz, Ana; Lopez-Martin, Estrella; Berglund, Marika; Larsson, Kristin; Lehmann, Andrea; Crettaz, Pierre; Schoeters, Greet

First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale

BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. OBJECTIVES: We developed and applied a harmonized pr...

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Authors:	Den Hond, Elly, Govarts, Eva, Willems, Hanny, Smolders, Roel, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Schwedler, Gerda, Seiwert, Margarete, Fiddicke, Ulrike, Castaño, Argelia, Esteban-Lopez, Marta, Angerer, Jürgen, Koch, Holger M, Schindler, Birgit K, Sepai, Ovnair, Exley, Karen, Bloemen, Louis, Horvat, Milena, Knudsen, Lisbeth E, Joas, Anke, Joas, Reinhard, Biot, Pierre, Aerts, Dominique, Koppen, Gudrun, Katsonouri, Andromachi, Hadjipanayis, Adamos, Krskova, Andrea, Maly, Marek, Mørck, Thit A, Rudnai, Peter, Középesy, Szilvia, Mulcahy, Maurice, Mannion, Rory, Gutleb, Arno C, Fischer, Marc E, Ligocka, Danuta, Jakubowski, Marek, Reis, M Fátima, Namorado, Sónia, Gurzau, Anca Elena, Lupsa, Ioana-Rodica, Halzlova, Katarina, Jajcaj, Michal, Mazej, Darja, Tratnik, Janja Snoj, Lopez-Herranz, Ana, Lopez-Martin, Estrella, Berglund, Marika, Larsson, Kristin, Lehmann, Andrea, Crettaz, Pierre, Schoeters, Greet
Format:	article
Publication Date:	2015
Country:	España
Institution:	Instituto de Salud Carlos III (ISCIII)
Repository:	Repisalud
Language:	English
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/9951
Online Access:	http://hdl.handle.net/20.500.12105/9951
Access Level:	Open access
Keyword:	Adult Biomarkers Cadmium Child Child, Preschool Cotinine Environmental Exposure Environmental Medicine Environmental Pollutants Europe Female Hair Humans Male Mercury Mothers Phthalic Acids

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spelling	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scaleDen Hond, EllyGovarts, EvaWillems, HannySmolders, RoelCasteleyn, LudwineKolossa-Gehring, MarikeSchwedler, GerdaSeiwert, MargareteFiddicke, UlrikeCastaño, ArgeliaEsteban-Lopez, MartaAngerer, JürgenKoch, Holger MSchindler, Birgit KSepai, OvnairExley, KarenBloemen, LouisHorvat, MilenaKnudsen, Lisbeth EJoas, AnkeJoas, ReinhardBiot, PierreAerts, DominiqueKoppen, GudrunKatsonouri, AndromachiHadjipanayis, AdamosKrskova, AndreaMaly, MarekMørck, Thit ARudnai, PeterKözépesy, SzilviaMulcahy, MauriceMannion, RoryGutleb, Arno CFischer, Marc ELigocka, DanutaJakubowski, MarekReis, M FátimaNamorado, SóniaGurzau, Anca ElenaLupsa, Ioana-RodicaHalzlova, KatarinaJajcaj, MichalMazej, DarjaTratnik, Janja SnojLopez-Herranz, AnaLopez-Martin, EstrellaBerglund, MarikaLarsson, KristinLehmann, AndreaCrettaz, PierreSchoeters, GreetAdultBiomarkersCadmiumChildChild, PreschoolCotinineEnvironmental ExposureEnvironmental MedicineEnvironmental PollutantsEuropeFemaleHairHumansMaleMercuryMothersPhthalic AcidsBACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. OBJECTIVES: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe. METHODS: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines. RESULTS: Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values. CONCLUSIONS: We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.National Institute of Environmental Health Sciences (NIEHS)Unión Europea. Comisión Europea. 7 Programa Marco20202020-05-0720152015-03-0120152015-03-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/9951reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/99512026-06-12T12:43:37Z
dc.title.none.fl_str_mv	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
title	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
spellingShingle	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale Den Hond, Elly Adult Biomarkers Cadmium Child Child, Preschool Cotinine Environmental Exposure Environmental Medicine Environmental Pollutants Europe Female Hair Humans Male Mercury Mothers Phthalic Acids
title_short	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
title_full	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
title_fullStr	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
title_full_unstemmed	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
title_sort	First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale
dc.creator.none.fl_str_mv	Den Hond, Elly Govarts, Eva Willems, Hanny Smolders, Roel Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Seiwert, Margarete Fiddicke, Ulrike Castaño, Argelia Esteban-Lopez, Marta Angerer, Jürgen Koch, Holger M Schindler, Birgit K Sepai, Ovnair Exley, Karen Bloemen, Louis Horvat, Milena Knudsen, Lisbeth E Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique Koppen, Gudrun Katsonouri, Andromachi Hadjipanayis, Adamos Krskova, Andrea Maly, Marek Mørck, Thit A Rudnai, Peter Középesy, Szilvia Mulcahy, Maurice Mannion, Rory Gutleb, Arno C Fischer, Marc E Ligocka, Danuta Jakubowski, Marek Reis, M Fátima Namorado, Sónia Gurzau, Anca Elena Lupsa, Ioana-Rodica Halzlova, Katarina Jajcaj, Michal Mazej, Darja Tratnik, Janja Snoj Lopez-Herranz, Ana Lopez-Martin, Estrella Berglund, Marika Larsson, Kristin Lehmann, Andrea Crettaz, Pierre Schoeters, Greet
author	Den Hond, Elly
author_facet	Den Hond, Elly Govarts, Eva Willems, Hanny Smolders, Roel Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Seiwert, Margarete Fiddicke, Ulrike Castaño, Argelia Esteban-Lopez, Marta Angerer, Jürgen Koch, Holger M Schindler, Birgit K Sepai, Ovnair Exley, Karen Bloemen, Louis Horvat, Milena Knudsen, Lisbeth E Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique Koppen, Gudrun Katsonouri, Andromachi Hadjipanayis, Adamos Krskova, Andrea Maly, Marek Mørck, Thit A Rudnai, Peter Középesy, Szilvia Mulcahy, Maurice Mannion, Rory Gutleb, Arno C Fischer, Marc E Ligocka, Danuta Jakubowski, Marek Reis, M Fátima Namorado, Sónia Gurzau, Anca Elena Lupsa, Ioana-Rodica Halzlova, Katarina Jajcaj, Michal Mazej, Darja Tratnik, Janja Snoj Lopez-Herranz, Ana Lopez-Martin, Estrella Berglund, Marika Larsson, Kristin Lehmann, Andrea Crettaz, Pierre Schoeters, Greet
author_role	author
author2	Govarts, Eva Willems, Hanny Smolders, Roel Casteleyn, Ludwine Kolossa-Gehring, Marike Schwedler, Gerda Seiwert, Margarete Fiddicke, Ulrike Castaño, Argelia Esteban-Lopez, Marta Angerer, Jürgen Koch, Holger M Schindler, Birgit K Sepai, Ovnair Exley, Karen Bloemen, Louis Horvat, Milena Knudsen, Lisbeth E Joas, Anke Joas, Reinhard Biot, Pierre Aerts, Dominique Koppen, Gudrun Katsonouri, Andromachi Hadjipanayis, Adamos Krskova, Andrea Maly, Marek Mørck, Thit A Rudnai, Peter Középesy, Szilvia Mulcahy, Maurice Mannion, Rory Gutleb, Arno C Fischer, Marc E Ligocka, Danuta Jakubowski, Marek Reis, M Fátima Namorado, Sónia Gurzau, Anca Elena Lupsa, Ioana-Rodica Halzlova, Katarina Jajcaj, Michal Mazej, Darja Tratnik, Janja Snoj Lopez-Herranz, Ana Lopez-Martin, Estrella Berglund, Marika Larsson, Kristin Lehmann, Andrea Crettaz, Pierre Schoeters, Greet
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Unión Europea. Comisión Europea. 7 Programa Marco
dc.subject.none.fl_str_mv	Adult Biomarkers Cadmium Child Child, Preschool Cotinine Environmental Exposure Environmental Medicine Environmental Pollutants Europe Female Hair Humans Male Mercury Mothers Phthalic Acids
topic	Adult Biomarkers Cadmium Child Child, Preschool Cotinine Environmental Exposure Environmental Medicine Environmental Pollutants Europe Female Hair Humans Male Mercury Mothers Phthalic Acids
description	BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. OBJECTIVES: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe. METHODS: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines. RESULTS: Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values. CONCLUSIONS: We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.
publishDate	2015
dc.date.none.fl_str_mv	2015 2015-03-01 2015 2015-03-01 2020 2020-05-07
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/9951
url	http://hdl.handle.net/20.500.12105/9951
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv	National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale

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