First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale

BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. OBJECTIVES: We developed and applied a harmonized pr...

Descripción completa

Detalles Bibliográficos
Autores: Den Hond, Elly, Govarts, Eva, Willems, Hanny, Smolders, Roel, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Schwedler, Gerda, Seiwert, Margarete, Fiddicke, Ulrike, Castaño, Argelia, Esteban-Lopez, Marta, Angerer, Jürgen, Koch, Holger M, Schindler, Birgit K, Sepai, Ovnair, Exley, Karen, Bloemen, Louis, Horvat, Milena, Knudsen, Lisbeth E, Joas, Anke, Joas, Reinhard, Biot, Pierre, Aerts, Dominique, Koppen, Gudrun, Katsonouri, Andromachi, Hadjipanayis, Adamos, Krskova, Andrea, Maly, Marek, Mørck, Thit A, Rudnai, Peter, Középesy, Szilvia, Mulcahy, Maurice, Mannion, Rory, Gutleb, Arno C, Fischer, Marc E, Ligocka, Danuta, Jakubowski, Marek, Reis, M Fátima, Namorado, Sónia, Gurzau, Anca Elena, Lupsa, Ioana-Rodica, Halzlova, Katarina, Jajcaj, Michal, Mazej, Darja, Tratnik, Janja Snoj, Lopez-Herranz, Ana, Lopez-Martin, Estrella, Berglund, Marika, Larsson, Kristin, Lehmann, Andrea, Crettaz, Pierre, Schoeters, Greet
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/9951
Acceso en línea:http://hdl.handle.net/20.500.12105/9951
Access Level:acceso abierto
Palabra clave:Adult
Biomarkers
Cadmium
Child
Child, Preschool
Cotinine
Environmental Exposure
Environmental Medicine
Environmental Pollutants
Europe
Female
Hair
Humans
Male
Mercury
Mothers
Phthalic Acids
Descripción
Sumario:BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. OBJECTIVES: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe. METHODS: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines. RESULTS: Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values. CONCLUSIONS: We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.

Similares en LA Referencia