How does obstructive sleep apnea alter cerebral hemodynamics?
We aimed to characterize the cerebral hemodynamic response to obstructive sleep apnea/hypopnea events, and evaluate their association to polysomnographic parameters The characterization of the cerebral hemodynamics in obstructive sleep apnea (OSA) may add complementary information to further the und...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:301693 |
| Acceso en línea: | https://ddd.uab.cat/record/301693 https://dx.doi.org/urn:doi:10.1093/sleep/zsad122 |
| Access Level: | acceso abierto |
| Palabra clave: | Cerebral hemodynamics Diffuse correlation spectroscopy Near-infrared spectroscopy Obstructive sleep apnea Sleep disorder |
| Sumario: | We aimed to characterize the cerebral hemodynamic response to obstructive sleep apnea/hypopnea events, and evaluate their association to polysomnographic parameters The characterization of the cerebral hemodynamics in obstructive sleep apnea (OSA) may add complementary information to further the understanding of the severity of the syndrome beyond the conventional polysomnography. Severe OSA patients were studied during night sleep while monitored by polysomnography Transcranial, bed-side diffuse correlation spectroscopy (DCS) and frequency-domain near-infrared diffuse correlation spectroscopy (NIRS-DOS) were used to follow microvascular cerebral hemodynamics in the frontal lobes of the cerebral cortex Changes in cerebral blood flow (CBF), total hemoglobin concentration (THC), and cerebral blood oxygen saturation (StO2) were analyzed We considered 3283 obstructive apnea/hypopnea events from sixteen OSA patients (Age (median, interquartile range) 57 (52-64.5); females 25%; AHI (apnea-hypopnea index) 84.4 (76.1-93.7)) A biphasic response (maximum/minimum followed by a minimum/maximum) was observed for each cerebral hemodynamic variable (CBF, THC, StO2), heart rate and peripheral arterial oxygen saturation (SpO2) Changes of the StO2 followed the dynamics of the SpO2, and were out of phase from the THC and CBF Longer events were associated with larger CBF changes, faster responses and slower recoveries Moreover, the extrema of the response to obstructive hypopneas were lower compared to apneas (p < 001) Obstructive apneas/hypopneas cause profound, periodic changes in cerebral hemodynamics, including periods of hyper-and hypo-perfusion and intermittent cerebral hypoxia The duration of the events is a strong determinant of the cerebral hemodynamic response, which is more pronounced in apnea than hypopnea events. |
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