Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population
Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. To assess at baseline and after 1-year of follow-up associ...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/20306 |
| Acesso em linha: | https://hdl.handle.net/20.500.13003/20306 |
| Access Level: | acceso abierto |
| Palavra-chave: | Diabetes Mellitus, Type 2 Aged, 80 and over Aged Blood Glucose Homeostasis Humans Environmental Pollutants Middle Aged Fluorocarbons Male Diet Prospective Studies Alkanesulfonic Acids Female Body Mass Index Endocrine Disruptors Índice de Masa Corporal Femenino Ácidos Alcanesulfónicos Dieta Masculino Disruptores Endocrinos Fluorocarburos Contaminantes Ambientales Humanos Persona de Mediana Edad Glucemia Estudios Prospectivos Anciano Diabetes Mellitus Tipo 2 Anciano de 80 o más Años |
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Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior populationKhoury, NadineMartínez, María ÁngelesNishi, Stephanie KMartínez-González, Miguel ÁngelCorella, DoloresCastañer-Niño, OlgaMartínez, José AlfredoAlonso-Gomez, Angel M.Wärnberg, JuliaVioque, JesusRomaguera, DoraLópez-Miranda, JoséEstruch, RamonTinahones, Francisco JSantos-Lozano, José ManuelSerra-Majem, LluisBueno-Cavanillas, AuroraTur, Josep A.Cinza-Sanjurjo, SergioPintó, XavierJuan Gaforio, JoséMatía-Martín, PilarVidal, JosepVazquez, ClotildeDaimiel, LidiaRos, EmilioSayon-Orea, CarmenSorli, Jose V.Pérez-Vega, Karla-AlejandraGarcia-Rios, AntonioOrtiz-Díaz, FranciscoGómez-Gracia, EnriqueZulet, M AChaplin, AliceCasas, RosaSalcedo-Bellido, InmaculadaTojal-Sierra, LucasBernal-Lopez, Maria RosaVazquez-Ruiz, ZenaidaAsensio, Eva MGoday, AlbertPeña-Orihuela, Patricia JudithSignes-Pastor, Antonio JGarcia-Arellano, AnaFitó, MontseBabio, NancySalas-Salvado, JordiDiabetes Mellitus, Type 2Aged, 80 and overAgedBlood GlucoseHomeostasisHumansEnvironmental PollutantsMiddle AgedFluorocarbonsMaleDietProspective StudiesAlkanesulfonic AcidsFemaleBody Mass IndexEndocrine DisruptorsAged, 80 and overÍndice de Masa CorporalFemeninoÁcidos AlcanesulfónicosDietaMasculinoDisruptores EndocrinosFluorocarburosContaminantes AmbientalesHumanosPersona de Mediana EdadGlucemiaEstudios ProspectivosAncianoHomeostasisDiabetes Mellitus Tipo 2Anciano de 80 o más AñosEndocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. To assess at baseline and after 1-year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body-mass-index (BMI) in a senior population of 4600 non-diabetic participants from the PREDIMED-plus study. Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI. Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [β-coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p-trend ≤ 0.001], and fasting plasma glucose in the LB PFOS-DI [1.05 mg/dL(0.050 to 2.046),p-trend = 0.022]. Prospectively, a positive association between LB of PFOS-DI and BMI [0.06 kg/m2(0.014 to 0.106) per 1-SD increment of energy-adjusted PFOS-DI was shown. Participants in the top tertile showed an increase in HOMA-IR [0.06(0.016 to 0.097), p-trend = 0.005] compared to participants in the reference tertile after 1-year of follow-up. This is the first study to explore the association between DI of PFOS and glucose homeostasis. In this study, a high baseline DI of PFOS was associated with a higher levels of fasting plasma glucose and HbA1c and with an increase in HOMA-IR and BMI after 1-year of follow-up.Elsevier20242024-04-0120242024-04-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/20306reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/203062026-06-22T12:44:07Z |
| dc.title.none.fl_str_mv |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| title |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| spellingShingle |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population Khoury, Nadine Diabetes Mellitus, Type 2 Aged, 80 and over Aged Blood Glucose Homeostasis Humans Environmental Pollutants Middle Aged Fluorocarbons Male Diet Prospective Studies Alkanesulfonic Acids Female Body Mass Index Endocrine Disruptors Aged, 80 and over Índice de Masa Corporal Femenino Ácidos Alcanesulfónicos Dieta Masculino Disruptores Endocrinos Fluorocarburos Contaminantes Ambientales Humanos Persona de Mediana Edad Glucemia Estudios Prospectivos Anciano Homeostasis Diabetes Mellitus Tipo 2 Anciano de 80 o más Años |
| title_short |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| title_full |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| title_fullStr |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| title_full_unstemmed |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| title_sort |
Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population |
| dc.creator.none.fl_str_mv |
Khoury, Nadine Martínez, María Ángeles Nishi, Stephanie K Martínez-González, Miguel Ángel Corella, Dolores Castañer-Niño, Olga Martínez, José Alfredo Alonso-Gomez, Angel M. Wärnberg, Julia Vioque, Jesus Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J Santos-Lozano, José Manuel Serra-Majem, Lluis Bueno-Cavanillas, Aurora Tur, Josep A. Cinza-Sanjurjo, Sergio Pintó, Xavier Juan Gaforio, José Matía-Martín, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Sayon-Orea, Carmen Sorli, Jose V. Pérez-Vega, Karla-Alejandra Garcia-Rios, Antonio Ortiz-Díaz, Francisco Gómez-Gracia, Enrique Zulet, M A Chaplin, Alice Casas, Rosa Salcedo-Bellido, Inmaculada Tojal-Sierra, Lucas Bernal-Lopez, Maria Rosa Vazquez-Ruiz, Zenaida Asensio, Eva M Goday, Albert Peña-Orihuela, Patricia Judith Signes-Pastor, Antonio J Garcia-Arellano, Ana Fitó, Montse Babio, Nancy Salas-Salvado, Jordi |
| author |
Khoury, Nadine |
| author_facet |
Khoury, Nadine Martínez, María Ángeles Nishi, Stephanie K Martínez-González, Miguel Ángel Corella, Dolores Castañer-Niño, Olga Martínez, José Alfredo Alonso-Gomez, Angel M. Wärnberg, Julia Vioque, Jesus Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J Santos-Lozano, José Manuel Serra-Majem, Lluis Bueno-Cavanillas, Aurora Tur, Josep A. Cinza-Sanjurjo, Sergio Pintó, Xavier Juan Gaforio, José Matía-Martín, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Sayon-Orea, Carmen Sorli, Jose V. Pérez-Vega, Karla-Alejandra Garcia-Rios, Antonio Ortiz-Díaz, Francisco Gómez-Gracia, Enrique Zulet, M A Chaplin, Alice Casas, Rosa Salcedo-Bellido, Inmaculada Tojal-Sierra, Lucas Bernal-Lopez, Maria Rosa Vazquez-Ruiz, Zenaida Asensio, Eva M Goday, Albert Peña-Orihuela, Patricia Judith Signes-Pastor, Antonio J Garcia-Arellano, Ana Fitó, Montse Babio, Nancy Salas-Salvado, Jordi |
| author_role |
author |
| author2 |
Martínez, María Ángeles Nishi, Stephanie K Martínez-González, Miguel Ángel Corella, Dolores Castañer-Niño, Olga Martínez, José Alfredo Alonso-Gomez, Angel M. Wärnberg, Julia Vioque, Jesus Romaguera, Dora López-Miranda, José Estruch, Ramon Tinahones, Francisco J Santos-Lozano, José Manuel Serra-Majem, Lluis Bueno-Cavanillas, Aurora Tur, Josep A. Cinza-Sanjurjo, Sergio Pintó, Xavier Juan Gaforio, José Matía-Martín, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Sayon-Orea, Carmen Sorli, Jose V. Pérez-Vega, Karla-Alejandra Garcia-Rios, Antonio Ortiz-Díaz, Francisco Gómez-Gracia, Enrique Zulet, M A Chaplin, Alice Casas, Rosa Salcedo-Bellido, Inmaculada Tojal-Sierra, Lucas Bernal-Lopez, Maria Rosa Vazquez-Ruiz, Zenaida Asensio, Eva M Goday, Albert Peña-Orihuela, Patricia Judith Signes-Pastor, Antonio J Garcia-Arellano, Ana Fitó, Montse Babio, Nancy Salas-Salvado, Jordi |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
|
| dc.subject.none.fl_str_mv |
Diabetes Mellitus, Type 2 Aged, 80 and over Aged Blood Glucose Homeostasis Humans Environmental Pollutants Middle Aged Fluorocarbons Male Diet Prospective Studies Alkanesulfonic Acids Female Body Mass Index Endocrine Disruptors Aged, 80 and over Índice de Masa Corporal Femenino Ácidos Alcanesulfónicos Dieta Masculino Disruptores Endocrinos Fluorocarburos Contaminantes Ambientales Humanos Persona de Mediana Edad Glucemia Estudios Prospectivos Anciano Homeostasis Diabetes Mellitus Tipo 2 Anciano de 80 o más Años |
| topic |
Diabetes Mellitus, Type 2 Aged, 80 and over Aged Blood Glucose Homeostasis Humans Environmental Pollutants Middle Aged Fluorocarbons Male Diet Prospective Studies Alkanesulfonic Acids Female Body Mass Index Endocrine Disruptors Aged, 80 and over Índice de Masa Corporal Femenino Ácidos Alcanesulfónicos Dieta Masculino Disruptores Endocrinos Fluorocarburos Contaminantes Ambientales Humanos Persona de Mediana Edad Glucemia Estudios Prospectivos Anciano Homeostasis Diabetes Mellitus Tipo 2 Anciano de 80 o más Años |
| description |
Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. To assess at baseline and after 1-year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body-mass-index (BMI) in a senior population of 4600 non-diabetic participants from the PREDIMED-plus study. Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI. Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [β-coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p-trend ≤ 0.001], and fasting plasma glucose in the LB PFOS-DI [1.05 mg/dL(0.050 to 2.046),p-trend = 0.022]. Prospectively, a positive association between LB of PFOS-DI and BMI [0.06 kg/m2(0.014 to 0.106) per 1-SD increment of energy-adjusted PFOS-DI was shown. Participants in the top tertile showed an increase in HOMA-IR [0.06(0.016 to 0.097), p-trend = 0.005] compared to participants in the reference tertile after 1-year of follow-up. This is the first study to explore the association between DI of PFOS and glucose homeostasis. In this study, a high baseline DI of PFOS was associated with a higher levels of fasting plasma glucose and HbA1c and with an increase in HOMA-IR and BMI after 1-year of follow-up. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-04-01 2024 2024-04-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.13003/20306 |
| url |
https://hdl.handle.net/20.500.13003/20306 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears |
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Conselleria de Salut i Consum del Govern de les Illes Balears |
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Docusalut |
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15.81155 |