Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. To assess at baseline and after 1-year of follow-up associ...

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Detalles Bibliográficos
Autores: Khoury, Nadine, Martínez, María Ángeles, Nishi, Stephanie K, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer-Niño, Olga, Martínez, José Alfredo, Alonso-Gomez, Angel M., Wärnberg, Julia, Vioque, Jesus, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Santos-Lozano, José Manuel, Serra-Majem, Lluis, Bueno-Cavanillas, Aurora, Tur, Josep A., Cinza-Sanjurjo, Sergio, Pintó, Xavier, Juan Gaforio, José, Matía-Martín, Pilar, Vidal, Josep, Vazquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorli, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Ortiz-Díaz, Francisco, Gómez-Gracia, Enrique, Zulet, M A, Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria Rosa, Vazquez-Ruiz, Zenaida, Asensio, Eva M, Goday, Albert, Peña-Orihuela, Patricia Judith, Signes-Pastor, Antonio J, Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, Salas-Salvado, Jordi
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/20306
Acceso en línea:https://hdl.handle.net/20.500.13003/20306
Access Level:acceso abierto
Palabra clave:Diabetes Mellitus, Type 2
Aged, 80 and over
Aged
Blood Glucose
Homeostasis
Humans
Environmental Pollutants
Middle Aged
Fluorocarbons
Male
Diet
Prospective Studies
Alkanesulfonic Acids
Female
Body Mass Index
Endocrine Disruptors
Índice de Masa Corporal
Femenino
Ácidos Alcanesulfónicos
Dieta
Masculino
Disruptores Endocrinos
Fluorocarburos
Contaminantes Ambientales
Humanos
Persona de Mediana Edad
Glucemia
Estudios Prospectivos
Anciano
Diabetes Mellitus Tipo 2
Anciano de 80 o más Años
Descripción
Sumario:Endocrine disruptors (EDs) have emerged as potential contributors to the development of type-2 diabetes. Perfluorooctane sulfonate (PFOS), is one of these EDs linked with chronic diseases and gathered attention due to its widespread in food. To assess at baseline and after 1-year of follow-up associations between estimated dietary intake (DI) of PFOS, and glucose homeostasis parameters and body-mass-index (BMI) in a senior population of 4600 non-diabetic participants from the PREDIMED-plus study. Multivariable linear regression models were conducted to assess associations between baseline PFOS-DI at lower bound (LB) and upper bound (UB) established by the EFSA, glucose homeostasis parameters and BMI. Compared to those in the lowest tertile, participants in the highest tertile of baseline PFOS-DI in LB and UB showed higher levels of HbA1c [β-coefficient(CI)] [0.01 %(0.002 to 0.026), and [0.06 mg/dL(0.026 to 0.087), both p-trend ≤ 0.001], and fasting plasma glucose in the LB PFOS-DI [1.05 mg/dL(0.050 to 2.046),p-trend = 0.022]. Prospectively, a positive association between LB of PFOS-DI and BMI [0.06 kg/m2(0.014 to 0.106) per 1-SD increment of energy-adjusted PFOS-DI was shown. Participants in the top tertile showed an increase in HOMA-IR [0.06(0.016 to 0.097), p-trend = 0.005] compared to participants in the reference tertile after 1-year of follow-up. This is the first study to explore the association between DI of PFOS and glucose homeostasis. In this study, a high baseline DI of PFOS was associated with a higher levels of fasting plasma glucose and HbA1c and with an increase in HOMA-IR and BMI after 1-year of follow-up.

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