Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents

The experimental work presented in this memory is based on the hypothesis that quinoxalines di-N-oxide, considered to be the core of the structure, which present a carboxamide moiety on position two and aliphatic linker between this group and an aromatic system, can be proposed as potent anti-tuberc...

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Autor: Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa
Tipo de recurso: tesis doctoral
Fecha de publicación:2011
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/34367
Acceso en línea:https://hdl.handle.net/10171/34367
Access Level:acceso abierto
Palabra clave:Materias Investigacion::Farmacia
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spelling Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agentsMoreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfaMaterias Investigacion::FarmaciaThe experimental work presented in this memory is based on the hypothesis that quinoxalines di-N-oxide, considered to be the core of the structure, which present a carboxamide moiety on position two and aliphatic linker between this group and an aromatic system, can be proposed as potent anti-tuberculosis agents. The main purpose of this project is the synthesis of new quinoxaline di-N-oxide derivatives as anti-tuberculosis agents. The strategy consists of the design and synthesis of several derivatives of each series, and their in vitro biological evaluation against M.tb. Some compounds will be selected, based on their structural variability and biological results, for an in depth study of the physicochemical properties and electrochemical behavior of this family of derivatives. A series of specific objectives are proposed in order to achieve the main purpose of this project: 1. Bibliographic review: state of the art. 2. Design of new quinoxaline di-N-oxide derivatives. 3. Synthesis of the designed compounds. 4. Characterization of the synthesized compounds. 5. In vitro biological evaluation of the synthesized derivatives. 6. Study of the lipophilicity of quinoxaline di-N-oxide derivatives. 7. Study of the electrochemical behavior of quinoxaline di-N-oxide derivatives. 8. Study of possible structure-property and structure-activity relationships (SPR, SAR). 9. Search of new lead compounds and design of future work plans.Servicio de Publicaciones de la Universidad de NavarraPérez-Silanes, S. (Silvia)Monge, A. (Antonio)Dadun. Depósito Académico Digital Universidad de Navarra20132013-11-0620132013-01-0120132013-01-0120112011-06-17doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10171/34367reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/343672026-06-21T12:47:57Z
dc.title.none.fl_str_mv Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
title Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
spellingShingle Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa
Materias Investigacion::Farmacia
title_short Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
title_full Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
title_fullStr Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
title_full_unstemmed Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
title_sort Design, synthesis and study of quinoxaline-2- carboxamide 1,4-DI-N-Oxide derivatives as anti-tuberculosis agents
dc.creator.none.fl_str_mv Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa
author Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa
author_facet Moreno-de-Viguri, E. (Elsa)|||/items/08473f69-a6ab-4896-8cf9-41e6daf12bfa
author_role author
dc.contributor.none.fl_str_mv Pérez-Silanes, S. (Silvia)
Monge, A. (Antonio)
Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Materias Investigacion::Farmacia
topic Materias Investigacion::Farmacia
description The experimental work presented in this memory is based on the hypothesis that quinoxalines di-N-oxide, considered to be the core of the structure, which present a carboxamide moiety on position two and aliphatic linker between this group and an aromatic system, can be proposed as potent anti-tuberculosis agents. The main purpose of this project is the synthesis of new quinoxaline di-N-oxide derivatives as anti-tuberculosis agents. The strategy consists of the design and synthesis of several derivatives of each series, and their in vitro biological evaluation against M.tb. Some compounds will be selected, based on their structural variability and biological results, for an in depth study of the physicochemical properties and electrochemical behavior of this family of derivatives. A series of specific objectives are proposed in order to achieve the main purpose of this project: 1. Bibliographic review: state of the art. 2. Design of new quinoxaline di-N-oxide derivatives. 3. Synthesis of the designed compounds. 4. Characterization of the synthesized compounds. 5. In vitro biological evaluation of the synthesized derivatives. 6. Study of the lipophilicity of quinoxaline di-N-oxide derivatives. 7. Study of the electrochemical behavior of quinoxaline di-N-oxide derivatives. 8. Study of possible structure-property and structure-activity relationships (SPR, SAR). 9. Search of new lead compounds and design of future work plans.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-06-17
2013
2013-11-06
2013
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/34367
url https://hdl.handle.net/10171/34367
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
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dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Servicio de Publicaciones de la Universidad de Navarra
publisher.none.fl_str_mv Servicio de Publicaciones de la Universidad de Navarra
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
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