Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus

Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped...

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Detalles Bibliográficos
Autores: Gómez de Tejada Romero, María Jesús, Saavedra-Santana, P., de la Rosa-Fernández, F., Suárez-Ramírez, N., Martín-Martínez, A., Sosa-Henríquez, M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/144174
Acceso en línea:https://hdl.handle.net/11441/144174
https://doi.org/10.1007/s00592-022-01923-x
Access Level:acceso abierto
Palabra clave:Obesity
Diabetes Mellitus type 2
Vitamin D
Fragility fractures
Osteoporosis
Descripción
Sumario:Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered. Results Obese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes. Conclusions T2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women.

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