Fatal airway disease in an adult with chronic graft-versus-host disease

Chronic graft-versus-host disease (GVHD) is a syndrome of disordered immunity in which a variety of opportunistic respiratory infections have been documented. Restrictive pulmonary disease without advanced fibrotic changes has been also known to occur; obstructive lower airways disease related to ch...

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Authors: Roca Torrent, Josep, Grañena Batista, Alberto, Rodríguez-Roisin, Robert, Alvarez, P., Agusti-Vidal, A. (Albert), Rozman, Ciril, 1929-
Format: article
Status:Published version
Publication Date:1982
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/189851
Online Access:https://hdl.handle.net/2445/189851
Access Level:Open access
Keyword:Malalties del pulmó
Trasplantament d'òrgans
Complicacions quirúrgiques
Pulmonary diseases
Transplantation of organs
Complications of surgery
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spelling Fatal airway disease in an adult with chronic graft-versus-host diseaseRoca Torrent, JosepGrañena Batista, AlbertoRodríguez-Roisin, RobertAlvarez, P.Agusti-Vidal, A. (Albert)Rozman, Ciril, 1929-Malalties del pulmóTrasplantament d'òrgansComplicacions quirúrgiquesPulmonary diseasesTransplantation of organsComplications of surgeryChronic graft-versus-host disease (GVHD) is a syndrome of disordered immunity in which a variety of opportunistic respiratory infections have been documented. Restrictive pulmonary disease without advanced fibrotic changes has been also known to occur; obstructive lower airways disease related to chronic GVHD has apparently not been referred to. We report a patient with chronic GVHD and irreversible airways obstruction who died in respiratory failure caused by generalised bronchiolar damage progressing over a few months. Lung function studies showed severe airflow limitation and a leftward shift in the pressure-volume curve indicating a loss of elastic recoil pressure. Postmortem pulmonary lesions were consistent with a necrotising obliterative bron chiolitis. Our purpose is to describe this unusual complication not previously reported in chronic GVHD and discuss the pulmonary mechanics.BMJ Publishing Group1982info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/189851Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1136/thx.37.1.77Thorax, 1982, vol. 37, p. 77-78https://doi.org/10.1136/thx.37.1.77(c) BMJ Publishing Group, 1982info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1898512026-05-27T06:46:51Z
dc.title.none.fl_str_mv Fatal airway disease in an adult with chronic graft-versus-host disease
title Fatal airway disease in an adult with chronic graft-versus-host disease
spellingShingle Fatal airway disease in an adult with chronic graft-versus-host disease
Roca Torrent, Josep
Malalties del pulmó
Trasplantament d'òrgans
Complicacions quirúrgiques
Pulmonary diseases
Transplantation of organs
Complications of surgery
title_short Fatal airway disease in an adult with chronic graft-versus-host disease
title_full Fatal airway disease in an adult with chronic graft-versus-host disease
title_fullStr Fatal airway disease in an adult with chronic graft-versus-host disease
title_full_unstemmed Fatal airway disease in an adult with chronic graft-versus-host disease
title_sort Fatal airway disease in an adult with chronic graft-versus-host disease
dc.creator.none.fl_str_mv Roca Torrent, Josep
Grañena Batista, Alberto
Rodríguez-Roisin, Robert
Alvarez, P.
Agusti-Vidal, A. (Albert)
Rozman, Ciril, 1929-
author Roca Torrent, Josep
author_facet Roca Torrent, Josep
Grañena Batista, Alberto
Rodríguez-Roisin, Robert
Alvarez, P.
Agusti-Vidal, A. (Albert)
Rozman, Ciril, 1929-
author_role author
author2 Grañena Batista, Alberto
Rodríguez-Roisin, Robert
Alvarez, P.
Agusti-Vidal, A. (Albert)
Rozman, Ciril, 1929-
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malalties del pulmó
Trasplantament d'òrgans
Complicacions quirúrgiques
Pulmonary diseases
Transplantation of organs
Complications of surgery
topic Malalties del pulmó
Trasplantament d'òrgans
Complicacions quirúrgiques
Pulmonary diseases
Transplantation of organs
Complications of surgery
description Chronic graft-versus-host disease (GVHD) is a syndrome of disordered immunity in which a variety of opportunistic respiratory infections have been documented. Restrictive pulmonary disease without advanced fibrotic changes has been also known to occur; obstructive lower airways disease related to chronic GVHD has apparently not been referred to. We report a patient with chronic GVHD and irreversible airways obstruction who died in respiratory failure caused by generalised bronchiolar damage progressing over a few months. Lung function studies showed severe airflow limitation and a leftward shift in the pressure-volume curve indicating a loss of elastic recoil pressure. Postmortem pulmonary lesions were consistent with a necrotising obliterative bron chiolitis. Our purpose is to describe this unusual complication not previously reported in chronic GVHD and discuss the pulmonary mechanics.
publishDate 1982
dc.date.none.fl_str_mv 1982
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/189851
url https://hdl.handle.net/2445/189851
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1136/thx.37.1.77
Thorax, 1982, vol. 37, p. 77-78
https://doi.org/10.1136/thx.37.1.77
dc.rights.none.fl_str_mv (c) BMJ Publishing Group, 1982
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) BMJ Publishing Group, 1982
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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