Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort

Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established. This pan-European project, the DISCOvERIE project, aimed to characterize IBS pa...

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Authors: Midenfjord, Irina|||0000-0003-3168-1075, Khadija, Mahrukh, Sundelin, Elias|||0000-0001-6485-082X, Trindade, Inês A., Tornblom, Hans|||0000-0003-2117-9874, Santos, Javier|||0000-0002-4798-5033, Lobo Álvarez, Beatriz|||0000-0003-3391-7125, Mulder, Danique|||0000-0002-3927-4784, Vasquez, Alejandro Arias, Ruesing, Georgy, Reif, Andreas|||0000-0002-0992-634X, Aichholzer, Mareike|||0000-0002-1291-3304, Van Den Houte, Maaike, Van Oudenhove, Lukas|||0000-0002-6540-3113, Matteucci, Maria Chiara, Barbara, Giovanni|||0000-0001-9745-0726, Bosman, Michelle|||0000-0002-2040-2520, Jonkers, Daisy, Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350, Jekkel, Eva, Bitter, István|||0000-0002-9464-4709, Pop, Andrei-Vasile, Dumitrascu, Dan Lucian, Alonso Cotoner, Carmen|||0000-0002-3483-2919, Rodríguez-Urrutia, Amanda|||0000-0001-6882-205X, Simrén, Magnus
Format: article
Publication Date:2025
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:326294
Online Access:https://ddd.uab.cat/record/326294
https://dx.doi.org/urn:doi:10.1002/ueg2.70157
Access Level:Open access
Keyword:Anxiety
Chronic fatigue syndrome
Depression
Fibromyalgia
Gastrointestinal symptoms
IBS
Irritable bowel syndrome
Psychiatric diagnoses
Symptom burden
Symptom severity
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spelling Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European CohortResults From the DISCOvERIE ProjectMidenfjord, Irina|||0000-0003-3168-1075Khadija, MahrukhSundelin, Elias|||0000-0001-6485-082XTrindade, Inês A.Tornblom, Hans|||0000-0003-2117-9874Santos, Javier|||0000-0002-4798-5033Lobo Álvarez, Beatriz|||0000-0003-3391-7125Mulder, Danique|||0000-0002-3927-4784Vasquez, Alejandro AriasRuesing, GeorgyReif, Andreas|||0000-0002-0992-634XAichholzer, Mareike|||0000-0002-1291-3304Van Den Houte, MaaikeVan Oudenhove, Lukas|||0000-0002-6540-3113Matteucci, Maria ChiaraBarbara, Giovanni|||0000-0001-9745-0726Bosman, Michelle|||0000-0002-2040-2520Jonkers, DaisyRamos-Quiroga, Josep Antoni|||0000-0003-1622-0350Jekkel, EvaBitter, István|||0000-0002-9464-4709Pop, Andrei-VasileDumitrascu, Dan LucianAlonso Cotoner, Carmen|||0000-0002-3483-2919Rodríguez-Urrutia, Amanda|||0000-0001-6882-205XSimrén, MagnusAnxietyChronic fatigue syndromeDepressionFibromyalgiaGastrointestinal symptomsIBSIrritable bowel syndromePsychiatric diagnosesSymptom burdenSymptom severityPatients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established. This pan-European project, the DISCOvERIE project, aimed to characterize IBS patients with and without comorbid psychiatric (anxiety, depression) and/or somatic (fibromyalgia, chronic fatigue syndrome) conditions, and to compare them with disease (psychiatric and/or somatic condition without IBS) and healthy controls to further elucidate the effect of comorbid conditions on the disease burden in IBS. Participants from nine different European centers were included: IBS patients (Rome IV criteria) with and without comorbid conditions, disease controls, and healthy controls. The presence of comorbidities was assessed through the Mini International Neuropsychiatric Interview (MINI) for anxiety or depression or through diagnostic criteria for fibromyalgia or chronic fatigue syndrome. Validated questionnaires on IBS (IBS-SSS), depressive (PHQ-9), anxiety (GAD-7) and somatic symptom severity (PHQ-12), fibromyalgia symptoms (FIQ) and fatigue (MFI) were completed. In total, 842 participants were recruited between March 2021 and January 2023, of which 607 had IBS, 161 were disease controls and 74 were healthy controls. IBS, anxiety, depression, somatic symptoms and fatigue were more severe in IBS patients with comorbidities compared with IBS patients without comorbidities. The severity of the abovementioned symptoms all increased gradually with increasing number of comorbidities (all p.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/326294https://dx.doi.org/urn:doi:10.1002/ueg2.70157reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 848228open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3262942026-06-06T12:50:31Z
dc.title.none.fl_str_mv Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
Results From the DISCOvERIE Project
title Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
spellingShingle Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
Midenfjord, Irina|||0000-0003-3168-1075
Anxiety
Chronic fatigue syndrome
Depression
Fibromyalgia
Gastrointestinal symptoms
IBS
Irritable bowel syndrome
Psychiatric diagnoses
Symptom burden
Symptom severity
title_short Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
title_full Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
title_fullStr Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
title_full_unstemmed Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
title_sort Increased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort
dc.creator.none.fl_str_mv Midenfjord, Irina|||0000-0003-3168-1075
Khadija, Mahrukh
Sundelin, Elias|||0000-0001-6485-082X
Trindade, Inês A.
Tornblom, Hans|||0000-0003-2117-9874
Santos, Javier|||0000-0002-4798-5033
Lobo Álvarez, Beatriz|||0000-0003-3391-7125
Mulder, Danique|||0000-0002-3927-4784
Vasquez, Alejandro Arias
Ruesing, Georgy
Reif, Andreas|||0000-0002-0992-634X
Aichholzer, Mareike|||0000-0002-1291-3304
Van Den Houte, Maaike
Van Oudenhove, Lukas|||0000-0002-6540-3113
Matteucci, Maria Chiara
Barbara, Giovanni|||0000-0001-9745-0726
Bosman, Michelle|||0000-0002-2040-2520
Jonkers, Daisy
Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350
Jekkel, Eva
Bitter, István|||0000-0002-9464-4709
Pop, Andrei-Vasile
Dumitrascu, Dan Lucian
Alonso Cotoner, Carmen|||0000-0002-3483-2919
Rodríguez-Urrutia, Amanda|||0000-0001-6882-205X
Simrén, Magnus
author Midenfjord, Irina|||0000-0003-3168-1075
author_facet Midenfjord, Irina|||0000-0003-3168-1075
Khadija, Mahrukh
Sundelin, Elias|||0000-0001-6485-082X
Trindade, Inês A.
Tornblom, Hans|||0000-0003-2117-9874
Santos, Javier|||0000-0002-4798-5033
Lobo Álvarez, Beatriz|||0000-0003-3391-7125
Mulder, Danique|||0000-0002-3927-4784
Vasquez, Alejandro Arias
Ruesing, Georgy
Reif, Andreas|||0000-0002-0992-634X
Aichholzer, Mareike|||0000-0002-1291-3304
Van Den Houte, Maaike
Van Oudenhove, Lukas|||0000-0002-6540-3113
Matteucci, Maria Chiara
Barbara, Giovanni|||0000-0001-9745-0726
Bosman, Michelle|||0000-0002-2040-2520
Jonkers, Daisy
Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350
Jekkel, Eva
Bitter, István|||0000-0002-9464-4709
Pop, Andrei-Vasile
Dumitrascu, Dan Lucian
Alonso Cotoner, Carmen|||0000-0002-3483-2919
Rodríguez-Urrutia, Amanda|||0000-0001-6882-205X
Simrén, Magnus
author_role author
author2 Khadija, Mahrukh
Sundelin, Elias|||0000-0001-6485-082X
Trindade, Inês A.
Tornblom, Hans|||0000-0003-2117-9874
Santos, Javier|||0000-0002-4798-5033
Lobo Álvarez, Beatriz|||0000-0003-3391-7125
Mulder, Danique|||0000-0002-3927-4784
Vasquez, Alejandro Arias
Ruesing, Georgy
Reif, Andreas|||0000-0002-0992-634X
Aichholzer, Mareike|||0000-0002-1291-3304
Van Den Houte, Maaike
Van Oudenhove, Lukas|||0000-0002-6540-3113
Matteucci, Maria Chiara
Barbara, Giovanni|||0000-0001-9745-0726
Bosman, Michelle|||0000-0002-2040-2520
Jonkers, Daisy
Ramos-Quiroga, Josep Antoni|||0000-0003-1622-0350
Jekkel, Eva
Bitter, István|||0000-0002-9464-4709
Pop, Andrei-Vasile
Dumitrascu, Dan Lucian
Alonso Cotoner, Carmen|||0000-0002-3483-2919
Rodríguez-Urrutia, Amanda|||0000-0001-6882-205X
Simrén, Magnus
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Medicina
dc.subject.none.fl_str_mv Anxiety
Chronic fatigue syndrome
Depression
Fibromyalgia
Gastrointestinal symptoms
IBS
Irritable bowel syndrome
Psychiatric diagnoses
Symptom burden
Symptom severity
topic Anxiety
Chronic fatigue syndrome
Depression
Fibromyalgia
Gastrointestinal symptoms
IBS
Irritable bowel syndrome
Psychiatric diagnoses
Symptom burden
Symptom severity
description Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established. This pan-European project, the DISCOvERIE project, aimed to characterize IBS patients with and without comorbid psychiatric (anxiety, depression) and/or somatic (fibromyalgia, chronic fatigue syndrome) conditions, and to compare them with disease (psychiatric and/or somatic condition without IBS) and healthy controls to further elucidate the effect of comorbid conditions on the disease burden in IBS. Participants from nine different European centers were included: IBS patients (Rome IV criteria) with and without comorbid conditions, disease controls, and healthy controls. The presence of comorbidities was assessed through the Mini International Neuropsychiatric Interview (MINI) for anxiety or depression or through diagnostic criteria for fibromyalgia or chronic fatigue syndrome. Validated questionnaires on IBS (IBS-SSS), depressive (PHQ-9), anxiety (GAD-7) and somatic symptom severity (PHQ-12), fibromyalgia symptoms (FIQ) and fatigue (MFI) were completed. In total, 842 participants were recruited between March 2021 and January 2023, of which 607 had IBS, 161 were disease controls and 74 were healthy controls. IBS, anxiety, depression, somatic symptoms and fatigue were more severe in IBS patients with comorbidities compared with IBS patients without comorbidities. The severity of the abovementioned symptoms all increased gradually with increasing number of comorbidities (all p.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/326294
https://dx.doi.org/urn:doi:10.1002/ueg2.70157
url https://ddd.uab.cat/record/326294
https://dx.doi.org/urn:doi:10.1002/ueg2.70157
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 848228
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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