A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women

The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible inte...

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Authors: Pastor, Antoni, Fernández-Aranda, Fernando, Fitó, Montserrat, Jiménez-Murcia, Susana, Botella, Cristina, Fernández-Real, Jose M., Frühbeck, Gema, Tinahones, Francisco, Fagundo, Ana, Rodriguez, Joan, Agüera, Zaida, Langohr, Klaus|||0000-0001-7075-9192, Casanueva, Felipe F., de la Torre, Rafael
Format: article
Publication Date:2016
Country:España
Institution:Universitat Politècnica de Catalunya (UPC)
Repository:UPCommons. Portal del coneixement obert de la UPC
Language:English
OAI Identifier:oai:upcommons.upc.edu:2117/99399
Online Access:https://hdl.handle.net/2117/99399
https://dx.doi.org/10.1371/journal.pone.0148734
Access Level:Open access
Keyword:Biomathematics
Sampling (Statistics)
Biomatemàtica
Mostreig (Estadística)
Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària
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network_acronym_str ES
network_name_str España
repository_id_str
spelling A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in womenPastor, AntoniFernández-Aranda, FernandoFitó, MontserratJiménez-Murcia, SusanaBotella, CristinaFernández-Real, Jose M.Frühbeck, GemaTinahones, FranciscoFagundo, AnaRodriguez, JoanAgüera, ZaidaLangohr, Klaus|||0000-0001-7075-9192Casanueva, Felipe F.de la Torre, RafaelBiomathematicsSampling (Statistics)BiomatemàticaMostreig (Estadística)Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in generalClassificació AMS::62 Statistics::62D05 Sampling theory, sample surveysÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciènciesÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitàriaThe endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible interaction between olfaction, obesity and the eCB system. The study sample was made up of 161 females with five groups of body mass index sub-categories ranging from under-weight to morbidly obese. We assessed olfactory capacity with the “Sniffin´Sticks” test, which measures olfactory threshold-discrimination-identification (TDI) capacity. We measured plasma concentrations of the eCBs 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine or anandamide (AEA), and several eCB-related compounds, 2-acylglycerols and N-acylethanolamines. 2-AG and other 2-acylglycerols fasting plasma circulating plasma concentrations were higher in obese and morbidly obese subjects. AEA and other N-acylethanolamine circulating concentrations were lower in under-weight subjects. Olfactory TDI scores were lower in obese and morbidly obese subjects. Lower TDI scores were independently associated with higher 2-AG fasting plasma circulating concentrations, higher %body fat, and higher body mass index, after controlling for age, smoking, menstruation, and use of contraceptives. Our results show that obese subjects have a lower olfactory capacity than non-obese ones and that elevated fasting plasma circulating 2-AG concentrations in obesity are linked to a lower olfactory capacity. In agreement with previous studies we show that eCBs AEA and 2-AG, and their respective congeners have a distinct profile in relation to body mass index. The present report is the first study in humans in which olfactory capacity and circulating eCB concentrations have been measured in the same subjects.Peer Reviewed20162016-01-0120172017-01-17journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/99399https://dx.doi.org/10.1371/journal.pone.014873426849214reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/993992026-05-27T15:37:01Z
dc.title.none.fl_str_mv A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
title A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
spellingShingle A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
Pastor, Antoni
Biomathematics
Sampling (Statistics)
Biomatemàtica
Mostreig (Estadística)
Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària
title_short A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
title_full A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
title_fullStr A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
title_full_unstemmed A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
title_sort A lower olfactory capacity Is related to higher circulating concentrations of endocannabinoid 2-arachidonoylglycerol and higher body mass index in women
dc.creator.none.fl_str_mv Pastor, Antoni
Fernández-Aranda, Fernando
Fitó, Montserrat
Jiménez-Murcia, Susana
Botella, Cristina
Fernández-Real, Jose M.
Frühbeck, Gema
Tinahones, Francisco
Fagundo, Ana
Rodriguez, Joan
Agüera, Zaida
Langohr, Klaus|||0000-0001-7075-9192
Casanueva, Felipe F.
de la Torre, Rafael
author Pastor, Antoni
author_facet Pastor, Antoni
Fernández-Aranda, Fernando
Fitó, Montserrat
Jiménez-Murcia, Susana
Botella, Cristina
Fernández-Real, Jose M.
Frühbeck, Gema
Tinahones, Francisco
Fagundo, Ana
Rodriguez, Joan
Agüera, Zaida
Langohr, Klaus|||0000-0001-7075-9192
Casanueva, Felipe F.
de la Torre, Rafael
author_role author
author2 Fernández-Aranda, Fernando
Fitó, Montserrat
Jiménez-Murcia, Susana
Botella, Cristina
Fernández-Real, Jose M.
Frühbeck, Gema
Tinahones, Francisco
Fagundo, Ana
Rodriguez, Joan
Agüera, Zaida
Langohr, Klaus|||0000-0001-7075-9192
Casanueva, Felipe F.
de la Torre, Rafael
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biomathematics
Sampling (Statistics)
Biomatemàtica
Mostreig (Estadística)
Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària
topic Biomathematics
Sampling (Statistics)
Biomatemàtica
Mostreig (Estadística)
Classificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
Classificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
Àrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària
description The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. The eCB system is over-active in human obesity. Our aim is to measure circulating eCB concentrations and olfactory capacity in a human sample that includes people with obesity and explore the possible interaction between olfaction, obesity and the eCB system. The study sample was made up of 161 females with five groups of body mass index sub-categories ranging from under-weight to morbidly obese. We assessed olfactory capacity with the “Sniffin´Sticks” test, which measures olfactory threshold-discrimination-identification (TDI) capacity. We measured plasma concentrations of the eCBs 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine or anandamide (AEA), and several eCB-related compounds, 2-acylglycerols and N-acylethanolamines. 2-AG and other 2-acylglycerols fasting plasma circulating plasma concentrations were higher in obese and morbidly obese subjects. AEA and other N-acylethanolamine circulating concentrations were lower in under-weight subjects. Olfactory TDI scores were lower in obese and morbidly obese subjects. Lower TDI scores were independently associated with higher 2-AG fasting plasma circulating concentrations, higher %body fat, and higher body mass index, after controlling for age, smoking, menstruation, and use of contraceptives. Our results show that obese subjects have a lower olfactory capacity than non-obese ones and that elevated fasting plasma circulating 2-AG concentrations in obesity are linked to a lower olfactory capacity. In agreement with previous studies we show that eCBs AEA and 2-AG, and their respective congeners have a distinct profile in relation to body mass index. The present report is the first study in humans in which olfactory capacity and circulating eCB concentrations have been measured in the same subjects.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01
2017
2017-01-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/99399
https://dx.doi.org/10.1371/journal.pone.0148734
26849214
url https://hdl.handle.net/2117/99399
https://dx.doi.org/10.1371/journal.pone.0148734
identifier_str_mv 26849214
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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