Brain structure and function in school-aged children with sluggish cognitive tempo symptoms

Objective: Sluggish cognitive tempo (SCT) is a cluster of symptoms associated with poor function in various domains of major life activities that may comprise a novel attention disorder distinct from attention-deficit/hyperactivity disorder (ADHD). Nevertheless, very little is known about the neural...

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Detalles Bibliográficos
Autores: Camprodon-Rosanas, Ester, Pujol Martí, Jesús, 1981-, Martínez-Vilavella, Gerard, Blanco Hinojo, Laura, 1981-, Medrano-Martorell, Santiago, Batlle, Santiago, Forns i Guzman, Joan, 1981-, Ribas Fitó, Núria, Dolz, Montserrat, Sunyer Deu, Jordi
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/43715
Acceso en línea:http://hdl.handle.net/10230/43715
http://dx.doi.org/10.1016/j.jaac.2018.09.441
Access Level:acceso abierto
Palabra clave:Attention-deficit hyperactivity disorder
Executive function
FMRI
School-age children
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spelling Brain structure and function in school-aged children with sluggish cognitive tempo symptomsCamprodon-Rosanas, EsterPujol Martí, Jesús, 1981-Martínez-Vilavella, GerardBlanco Hinojo, Laura, 1981-Medrano-Martorell, SantiagoBatlle, SantiagoForns i Guzman, Joan, 1981-Ribas Fitó, NúriaDolz, MontserratSunyer Deu, JordiAttention-deficit hyperactivity disorderExecutive functionFMRISchool-age childrenObjective: Sluggish cognitive tempo (SCT) is a cluster of symptoms associated with poor function in various domains of major life activities that may comprise a novel attention disorder distinct from attention-deficit/hyperactivity disorder (ADHD). Nevertheless, very little is known about the neural substrate of SCT in children. The present study aimed to examine associations between SCT symptoms and brain structure and function in school-aged children. Method: We performed a cross-sectional MRI study in 178 children 8 to 12 years old from primary schools in Barcelona, Spain. Data were collected between January 2012 and March 2013. Parents completed the Sluggish Cognitive Tempo-Child Behavior Checklist (SCT-CBCL). Participants underwent magnetic resonance imaging to assess regional brain volume, white matter integrity using diffusion tensor imaging, and functional connectivity in major neural networks. Results: SCT symptoms were associated with altered anatomy of the frontal lobe in the form of increased regional volume. The anomalously large cortical regions were less mature in terms of functional connectivity. Importantly, all the anatomical and functional anomalies identified remained significant after adjusting the analyses for ADHD symptom scores. Conclusion: Our results suggest that SCT symptoms are associated with distinct features of brain structure and function that differ from the classical neural substrates described in ADHD.This work was supported by the European Research Council under the ERC (grant number 268479)—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government part icipated in the context of Research Group SGR2014-167Elsevier202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43715http://dx.doi.org/10.1016/j.jaac.2018.09.441reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJournal of the American Academy of Child and Adolescent Psychiatry. 2019;58(2):256-66info:eu-repo/grantAgreement/EC/FP7/268479© Elsevier http://dx.doi.org/10.1016/j.jaac.2018.09.441info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/437152026-06-12T07:21:37Z
dc.title.none.fl_str_mv Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
title Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
spellingShingle Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
Camprodon-Rosanas, Ester
Attention-deficit hyperactivity disorder
Executive function
FMRI
School-age children
title_short Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
title_full Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
title_fullStr Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
title_full_unstemmed Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
title_sort Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
dc.creator.none.fl_str_mv Camprodon-Rosanas, Ester
Pujol Martí, Jesús, 1981-
Martínez-Vilavella, Gerard
Blanco Hinojo, Laura, 1981-
Medrano-Martorell, Santiago
Batlle, Santiago
Forns i Guzman, Joan, 1981-
Ribas Fitó, Núria
Dolz, Montserrat
Sunyer Deu, Jordi
author Camprodon-Rosanas, Ester
author_facet Camprodon-Rosanas, Ester
Pujol Martí, Jesús, 1981-
Martínez-Vilavella, Gerard
Blanco Hinojo, Laura, 1981-
Medrano-Martorell, Santiago
Batlle, Santiago
Forns i Guzman, Joan, 1981-
Ribas Fitó, Núria
Dolz, Montserrat
Sunyer Deu, Jordi
author_role author
author2 Pujol Martí, Jesús, 1981-
Martínez-Vilavella, Gerard
Blanco Hinojo, Laura, 1981-
Medrano-Martorell, Santiago
Batlle, Santiago
Forns i Guzman, Joan, 1981-
Ribas Fitó, Núria
Dolz, Montserrat
Sunyer Deu, Jordi
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Attention-deficit hyperactivity disorder
Executive function
FMRI
School-age children
topic Attention-deficit hyperactivity disorder
Executive function
FMRI
School-age children
description Objective: Sluggish cognitive tempo (SCT) is a cluster of symptoms associated with poor function in various domains of major life activities that may comprise a novel attention disorder distinct from attention-deficit/hyperactivity disorder (ADHD). Nevertheless, very little is known about the neural substrate of SCT in children. The present study aimed to examine associations between SCT symptoms and brain structure and function in school-aged children. Method: We performed a cross-sectional MRI study in 178 children 8 to 12 years old from primary schools in Barcelona, Spain. Data were collected between January 2012 and March 2013. Parents completed the Sluggish Cognitive Tempo-Child Behavior Checklist (SCT-CBCL). Participants underwent magnetic resonance imaging to assess regional brain volume, white matter integrity using diffusion tensor imaging, and functional connectivity in major neural networks. Results: SCT symptoms were associated with altered anatomy of the frontal lobe in the form of increased regional volume. The anomalously large cortical regions were less mature in terms of functional connectivity. Importantly, all the anatomical and functional anomalies identified remained significant after adjusting the analyses for ADHD symptom scores. Conclusion: Our results suggest that SCT symptoms are associated with distinct features of brain structure and function that differ from the classical neural substrates described in ADHD.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/43715
http://dx.doi.org/10.1016/j.jaac.2018.09.441
url http://hdl.handle.net/10230/43715
http://dx.doi.org/10.1016/j.jaac.2018.09.441
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of the American Academy of Child and Adolescent Psychiatry. 2019;58(2):256-66
info:eu-repo/grantAgreement/EC/FP7/268479
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.jaac.2018.09.441
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.jaac.2018.09.441
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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