Corpus callosum atrophy in adolescents with antecedents of moderate perinatal asphyxia
Background: The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemic encephalopathy (HIE) causes callosal damage. Primary objective: To quantify the CC surface in a sample of patients...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2003 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/226900 |
| Acceso en línea: | https://hdl.handle.net/2445/226900 |
| Access Level: | acceso abierto |
| Palabra clave: | Neurologia pediàtrica Lesions cerebrals Asfíxia neonatal Pediatric neurology Brain damage Asphyxia neonatorum |
| Sumario: | Background: The corpus callosum (CC) is a cerebral structure that reflects cognitive status in several neurological pathologies. Visual inspection of MRI has shown that hypoxic-ischemic encephalopathy (HIE) causes callosal damage. Primary objective: To quantify the CC surface in a sample of patients with antecedents of HIE and a group of matched controls. Research design: Comparisons of CC measures among control subjects, mild HIE patients and moderate HIE patients as well as correlates of CC surface and neuropsychological performance. Methods: Twenty-one adolescent patients with childhood antecedents of HIE were compared to 21 controls. ANALYZE software was used to semi-automatically measure the CC area. Main outcomes and results: Patients with moderate HIE showed corpus callosum reduction. The isthmus and genus were the most affected regions. Corpus callosum size correlated with cognitive function. Conclusions: Corpus callosum quantification provides new evidence of subtle residual deficits in subjects with HIE antecedents without apparent neurological sequelae. |
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