1-H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia

The authors performed neuropsychological and 1H-MRS studies in 18 subclinical patients with antecedents of perinatal asphyxia (PA) and in 18 matched control subjects. Patients with PA showed reduced values of N-acetylaspartate (NAA) in both the basal ganglia and the midtemporal region (MTR) and redu...

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Detalles Bibliográficos
Autores: Mañeru Zunazarren, Cristina, Junqué i Plaja, Carme, 1955-, Bargalló Alabart, Núria, Olondo, M., Botet Mussons, Francisco, Tallada, Mercé, Guàrdia-Olmos, Joan, 1958-, Mercader Sobrequés, José Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2001
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/223643
Acceso en línea:https://hdl.handle.net/2445/223643
Access Level:acceso abierto
Palabra clave:Trastorns de la cognició
Lesions cerebrals
Asfíxia neonatal
Cognition disorders
Brain damage
Asphyxia neonatorum
Descripción
Sumario:The authors performed neuropsychological and 1H-MRS studies in 18 subclinical patients with antecedents of perinatal asphyxia (PA) and in 18 matched control subjects. Patients with PA showed reduced values of N-acetylaspartate (NAA) in both the basal ganglia and the midtemporal region (MTR) and reduced NAA/choline values in the MTR. Neuropsychological testing showed group differences in tasks related to attention and memory. These results indicate persistent dysfunctions in cerebral structures vulnerable to hypoxia and demonstrate the utility of MRS for the long-term evaluation of cerebral sequelae of neonatal asphyxia.

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