Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems

Supercritical fluid technology offers great advantages in the field of materials processing for pharmaceutical applications. On one hand, it allows for the processing of materials into microparticles via micronization, reducing or avoiding the use of organic solvents and multi-step processes. On the...

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Detalhes bibliográficos
Autor: López Iglesias, Clara
Formato: tesis doctoral
Fecha de publicación:2020
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/24539
Acesso em linha:http://hdl.handle.net/10347/24539
Access Level:acceso abierto
Palavra-chave:Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
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spelling Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systemsLópez Iglesias, ClaraMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosMaterias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materialesSupercritical fluid technology offers great advantages in the field of materials processing for pharmaceutical applications. On one hand, it allows for the processing of materials into microparticles via micronization, reducing or avoiding the use of organic solvents and multi-step processes. On the other hand, supercritical fluids can be used for the extraction of the liquid phase of gels to obtain aerogels without significant damage in the porous structure. In this PhD Thesis, supercritical fluids were applied in the preparation of drug delivery systems for wound treatment and pulmonary administration. A supercritical CO2-based micronization process, the PGSS technique, was modeled and applied for the production of lipid microparticles loaded with lidocaine HCl, an anesthetic drug with antibacterial properties, for wound applications. Chitosan aerogel particles loaded with the anbitiotic drug vancomycin HCl were produced by the dripping method and the jet cutting technique and studied for specific chronic wound applications. Finally, the technological combination of the inkjet printing technique and supercritical drying was proposed and developed for the production of alginate microparticles with suitable aerodynamic diameters for the pulmonary delivery of salbutamol sulphate, used in the treatment of chronic respiratory diseases.Álvarez Lorenzo, CarmenGarcía González, Carlos A.Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20202020-01-0120202020-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/24539reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/245392026-06-15T12:47:27Z
dc.title.none.fl_str_mv Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
title Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
spellingShingle Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
López Iglesias, Clara
Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
title_short Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
title_full Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
title_fullStr Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
title_full_unstemmed Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
title_sort Aerogel and supercritical technology for the development of skin and pulmonary drug delivery systems
dc.creator.none.fl_str_mv López Iglesias, Clara
author López Iglesias, Clara
author_facet López Iglesias, Clara
author_role author
dc.contributor.none.fl_str_mv Álvarez Lorenzo, Carmen
García González, Carlos A.
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
topic Materias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentos
Materias::Investigación::33 Ciencias tecnológicas::3312 Tecnología de materiales
description Supercritical fluid technology offers great advantages in the field of materials processing for pharmaceutical applications. On one hand, it allows for the processing of materials into microparticles via micronization, reducing or avoiding the use of organic solvents and multi-step processes. On the other hand, supercritical fluids can be used for the extraction of the liquid phase of gels to obtain aerogels without significant damage in the porous structure. In this PhD Thesis, supercritical fluids were applied in the preparation of drug delivery systems for wound treatment and pulmonary administration. A supercritical CO2-based micronization process, the PGSS technique, was modeled and applied for the production of lipid microparticles loaded with lidocaine HCl, an anesthetic drug with antibacterial properties, for wound applications. Chitosan aerogel particles loaded with the anbitiotic drug vancomycin HCl were produced by the dripping method and the jet cutting technique and studied for specific chronic wound applications. Finally, the technological combination of the inkjet printing technique and supercritical drying was proposed and developed for the production of alginate microparticles with suitable aerodynamic diameters for the pulmonary delivery of salbutamol sulphate, used in the treatment of chronic respiratory diseases.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/24539
url http://hdl.handle.net/10347/24539
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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