Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study

Background: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes. Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated...

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Autores: Guasch-Ferre, M, Becerra-Tomas, N, Ruiz-Canela, M, Corella, D, Schroder, H, Estruch, R, Ros, E, Aros, F, Gomez-Gracia, E, Fiol, M, Serra-Majem, L, Lapetra, J, Basora, J, Martin-Calvo, N, Portoles, O, Fito, M, Hu, FB, Forga, L, Salas-Salvado, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p4634
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/4634
Access Level:acceso abierto
Palabra clave:dietary fat
fat subtypes
saturated fat
monounsaturated fat
omega-3 fatty acids
type 2 diabetes
PREDIMED study
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spelling Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) studyGuasch-Ferre, MBecerra-Tomas, NRuiz-Canela, MCorella, DSchroder, HEstruch, RRos, EAros, FGomez-Gracia, EFiol, MSerra-Majem, LLapetra, JBasora, JMartin-Calvo, NPortoles, OFito, MHu, FBForga, LSalas-Salvado, Jdietary fatfat subtypessaturated fatmonounsaturated fatomega-3 fatty acidstype 2 diabetesPREDIMED studyBackground: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes. Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty acids and the incidence of type 2 diabetes (T2D). Design: A prospective cohort analysis of 3349 individuals who were free of diabetes at baseline but were at high cardiovascular risk from the PREvencion con DIeta MEDiterranea (PREDIMED) study was conducted. Detailed dietary information was assessed at baseline and yearly during the follow-up using a food frequency questionnaire. Multivariable Cox proportional hazards models were used to estimate T2D HRs and 95% CIs according to baseline and yearly updated fat intake. Results: We documented 266 incident cases during 4.3 y of follow-up. Baseline saturated and animal fat intake was not associated with the risk of T2D. After multivariable adjustment, participants in the highest quartile of updated intake of saturated and animal fat had a higher risk of diabetes than the lowest quartile (HR: 2.19; 95% CI: 1.28, 3.73; and P-trend = 0.01 compared with HR: 2.00; 95% CI: 1.29, 3.09; and P-trend < 0.01, respectively). In both the Mediterranean diet and control groups, participants in the highest quartile of updated animal fat intake had anw2-fold higher risk of T2D than their counterparts in the lowest quartile. The consumption of 1 serving of butter and cheese was associated with a higher risk of diabetes, whereas whole-fat yogurt intake was associated with a lower risk. Conclusions: In a Mediterranean trial focused on dietary fat interventions, baseline intake of saturated and animal fat was not associated with T2D incidence, but the yearly updated intake of saturated and animal fat was associated with a higher risk of T2D. Cheese and butter intake was associated with a higher risk of T2D, whereas whole-fat yogurt intake was associated with a lower risk of T2D.ELSEVIER SCIENCE INC2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/4634AMERICAN JOURNAL OF CLINICAL NUTRITIONISSN: 00029165ISSNe: 19383207reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p46342026-06-07T16:35:31Z
dc.title.none.fl_str_mv Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
title Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
spellingShingle Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
Guasch-Ferre, M
dietary fat
fat subtypes
saturated fat
monounsaturated fat
omega-3 fatty acids
type 2 diabetes
PREDIMED study
title_short Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
title_full Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
title_fullStr Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
title_full_unstemmed Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
title_sort Total and subtypes of dietary fat intake and risk of type 2 diabetes mellitus in the Prevencion con Dieta Mediterranea (PREDIMED) study
dc.creator.none.fl_str_mv Guasch-Ferre, M
Becerra-Tomas, N
Ruiz-Canela, M
Corella, D
Schroder, H
Estruch, R
Ros, E
Aros, F
Gomez-Gracia, E
Fiol, M
Serra-Majem, L
Lapetra, J
Basora, J
Martin-Calvo, N
Portoles, O
Fito, M
Hu, FB
Forga, L
Salas-Salvado, J
author Guasch-Ferre, M
author_facet Guasch-Ferre, M
Becerra-Tomas, N
Ruiz-Canela, M
Corella, D
Schroder, H
Estruch, R
Ros, E
Aros, F
Gomez-Gracia, E
Fiol, M
Serra-Majem, L
Lapetra, J
Basora, J
Martin-Calvo, N
Portoles, O
Fito, M
Hu, FB
Forga, L
Salas-Salvado, J
author_role author
author2 Becerra-Tomas, N
Ruiz-Canela, M
Corella, D
Schroder, H
Estruch, R
Ros, E
Aros, F
Gomez-Gracia, E
Fiol, M
Serra-Majem, L
Lapetra, J
Basora, J
Martin-Calvo, N
Portoles, O
Fito, M
Hu, FB
Forga, L
Salas-Salvado, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv dietary fat
fat subtypes
saturated fat
monounsaturated fat
omega-3 fatty acids
type 2 diabetes
PREDIMED study
topic dietary fat
fat subtypes
saturated fat
monounsaturated fat
omega-3 fatty acids
type 2 diabetes
PREDIMED study
description Background: The associations between dietary fat and cardiovascular disease have been evaluated in several studies, but less is known about their influence on the risk of diabetes. Objective: We examined the associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty acids and the incidence of type 2 diabetes (T2D). Design: A prospective cohort analysis of 3349 individuals who were free of diabetes at baseline but were at high cardiovascular risk from the PREvencion con DIeta MEDiterranea (PREDIMED) study was conducted. Detailed dietary information was assessed at baseline and yearly during the follow-up using a food frequency questionnaire. Multivariable Cox proportional hazards models were used to estimate T2D HRs and 95% CIs according to baseline and yearly updated fat intake. Results: We documented 266 incident cases during 4.3 y of follow-up. Baseline saturated and animal fat intake was not associated with the risk of T2D. After multivariable adjustment, participants in the highest quartile of updated intake of saturated and animal fat had a higher risk of diabetes than the lowest quartile (HR: 2.19; 95% CI: 1.28, 3.73; and P-trend = 0.01 compared with HR: 2.00; 95% CI: 1.29, 3.09; and P-trend < 0.01, respectively). In both the Mediterranean diet and control groups, participants in the highest quartile of updated animal fat intake had anw2-fold higher risk of T2D than their counterparts in the lowest quartile. The consumption of 1 serving of butter and cheese was associated with a higher risk of diabetes, whereas whole-fat yogurt intake was associated with a lower risk. Conclusions: In a Mediterranean trial focused on dietary fat interventions, baseline intake of saturated and animal fat was not associated with T2D incidence, but the yearly updated intake of saturated and animal fat was associated with a higher risk of T2D. Cheese and butter intake was associated with a higher risk of T2D, whereas whole-fat yogurt intake was associated with a lower risk of T2D.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/4634
url https://incliva.portalinvestigacion.com/publicaciones/4634
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv AMERICAN JOURNAL OF CLINICAL NUTRITION
ISSN: 00029165
ISSNe: 19383207
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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