Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors

Microviscosity is a key parameter controlling the rate of diffusion and reactions on the microscale. One of the most convenient tools for measuring microviscosity is by fluorescent viscosity sensors termed ‘molecular rotors’. BODIPY-based molecular rotors in particular proved extremely useful in com...

Full description

Bibliographic Details
Authors: Vyšniauskas, Aurimas, López Duarte, Ismael, Duchemin, Nicolas, Vu, Thanh-Truc, Wu, Yilei, Budynina, Ekaterina M., Volkova, Yulia A., Peña Cabrera, Eduardo, Ramírez-Ornelas, Diana E., Kuimova, Marina K.
Format: article
Publication Date:2017
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/114926
Online Access:https://hdl.handle.net/20.500.14352/114926
Access Level:Open access
Keyword:615.31
615:54
Química farmaceútica
23 Química
id ES_a031d9b9ab64b4da490cbbd9b30ccf93
oai_identifier_str oai:docta.ucm.es:20.500.14352/114926
network_acronym_str ES
network_name_str España
repository_id_str
spelling Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotorsVyšniauskas, AurimasLópez Duarte, IsmaelDuchemin, NicolasVu, Thanh-TrucWu, YileiBudynina, Ekaterina M.Volkova, Yulia A.Peña Cabrera, EduardoRamírez-Ornelas, Diana E.Kuimova, Marina K.615.31615:54Química farmaceútica23 QuímicaMicroviscosity is a key parameter controlling the rate of diffusion and reactions on the microscale. One of the most convenient tools for measuring microviscosity is by fluorescent viscosity sensors termed ‘molecular rotors’. BODIPY-based molecular rotors in particular proved extremely useful in combination with fluorescence lifetime imaging microscopy, for providing quantitative viscosity maps of living cells as well as measuring dynamic changes in viscosity over time. In this work, we investigate several new BODIPY-based molecular rotors with the aim of improving on the current viscosity sensing capabilities and understanding how the structure of the fluorophore is related to its function. We demonstrate that due to subtle structural changes, BODIPY-based molecular rotors may become sensitive to temperature and polarity of their environment, as well as to viscosity, and provide a photophysical model explaining the nature of this sensitivity. Our data suggests that a thorough understanding of the photophysics of any new molecular rotor, in environments of different viscosity, temperature and polarity, is a must before moving on to applications in viscosity sensing.Royal Society of ChemistryUniversidad Complutense de Madrid20172017-01-0120172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/114926reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1149262026-06-02T12:44:21Z
dc.title.none.fl_str_mv Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
title Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
spellingShingle Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
Vyšniauskas, Aurimas
615.31
615:54
Química farmaceútica
23 Química
title_short Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
title_full Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
title_fullStr Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
title_full_unstemmed Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
title_sort Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors
dc.creator.none.fl_str_mv Vyšniauskas, Aurimas
López Duarte, Ismael
Duchemin, Nicolas
Vu, Thanh-Truc
Wu, Yilei
Budynina, Ekaterina M.
Volkova, Yulia A.
Peña Cabrera, Eduardo
Ramírez-Ornelas, Diana E.
Kuimova, Marina K.
author Vyšniauskas, Aurimas
author_facet Vyšniauskas, Aurimas
López Duarte, Ismael
Duchemin, Nicolas
Vu, Thanh-Truc
Wu, Yilei
Budynina, Ekaterina M.
Volkova, Yulia A.
Peña Cabrera, Eduardo
Ramírez-Ornelas, Diana E.
Kuimova, Marina K.
author_role author
author2 López Duarte, Ismael
Duchemin, Nicolas
Vu, Thanh-Truc
Wu, Yilei
Budynina, Ekaterina M.
Volkova, Yulia A.
Peña Cabrera, Eduardo
Ramírez-Ornelas, Diana E.
Kuimova, Marina K.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.31
615:54
Química farmaceútica
23 Química
topic 615.31
615:54
Química farmaceútica
23 Química
description Microviscosity is a key parameter controlling the rate of diffusion and reactions on the microscale. One of the most convenient tools for measuring microviscosity is by fluorescent viscosity sensors termed ‘molecular rotors’. BODIPY-based molecular rotors in particular proved extremely useful in combination with fluorescence lifetime imaging microscopy, for providing quantitative viscosity maps of living cells as well as measuring dynamic changes in viscosity over time. In this work, we investigate several new BODIPY-based molecular rotors with the aim of improving on the current viscosity sensing capabilities and understanding how the structure of the fluorophore is related to its function. We demonstrate that due to subtle structural changes, BODIPY-based molecular rotors may become sensitive to temperature and polarity of their environment, as well as to viscosity, and provide a photophysical model explaining the nature of this sensitivity. Our data suggests that a thorough understanding of the photophysics of any new molecular rotor, in environments of different viscosity, temperature and polarity, is a must before moving on to applications in viscosity sensing.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/114926
url https://hdl.handle.net/20.500.14352/114926
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414990550663168
score 15,811543

Similar Items