Visualising the membrane viscosity of porcine eye lens cells using molecular rotors

The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive ‘molecular rotors’ to map the microscopic viscosity within...

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Detalles Bibliográficos
Autores: Peter S. S, Peter S. herin, López Duarte, Ismael, Dent, Michael R., Markéta Kubánková, Vyšniauskas, Aurimas, Bull, James A., Reshetnikova, Evdokiya S., Klymchenko, Andrey S., Tsentalovich, Yuri P., Kuimova, Marina K.
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/114903
Acceso en línea:https://hdl.handle.net/20.500.14352/114903
Access Level:acceso abierto
Palabra clave:615.31
615:54
Química farmaceútica
23 Química
Descripción
Sumario:The plasma membranes of cells within the eye lens play an important role in metabolite transport within the avascular tissue of the lens, maintaining its transparency over the entire lifespan of an individual. Here we use viscosity-sensitive ‘molecular rotors’ to map the microscopic viscosity within these unusual cell membranes, establishing that they are characterised by an unprecedentedly high degree of lipid organisation.