SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling
15 p.-7 fig.
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/334280 |
| Acceso en línea: | http://hdl.handle.net/10261/334280 |
| Access Level: | acceso abierto |
| Palabra clave: | SARS-CoV-2 Accessory proteins IL11 Lung Fibrosis COVID-19 |
| id |
ES_a018dd5f04d87f7b33f7bcbc32fad601 |
|---|---|
| oai_identifier_str |
oai:digital.csic.es:10261/334280 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signalingLópez-Ayllón, Blanca D.Lucas-Rius, Ana deMendoza-García, LauraGarcía-García, TránsitoFernández-Rodríguez, RaúlSuárez-Cárdenas, José M.Milhano, FátimaCorrales, Fernando J.Redondo, NataliaPedrucci, FedericaZaldívar-López, SaraJiménez-Marín, ÁngelesGarrido, Juan J.Montoya, MaríaSARS-CoV-2Accessory proteinsIL11LungFibrosisCOVID-1915 p.-7 fig.SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549 cells expressing individual accessory proteins ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). IL11 is a member of the IL6 family of cytokines. IL11 signaling-related genes were also differentially expressed. Bioinformatics analysis disclosed that both WNT5A and IL11 were involved in pulmonary fibrosis idiopathic disease and functional assays confirmed their association with profibrotic cell responses. Subsequently, data comparison with lung cell lines infected with SARS-CoV-2 or lung biopsies from patients with COVID-19, evidenced altered profibrotic gene expression that matched those obtained in this study. Our results show ORF6, ORF8, ORF9b and ORF9c involvement in inflammatory and profibrotic responses. Thus, these accessory proteins could be targeted by new therapies against COVID-19 disease.This research work was funded by the European Commission – NextGenerationEU (Regulation EU 2020/2094), through CSIC’s Global Health Platform (PTI+ Salud Global) (COVID-19-117 and SGL2103015), Junta de Andalucía (CV20-20089) and Spanish Ministry of Science project (PID2021-123399OB-I00).Peer reviewedFrontiers MediaEuropean CommissionJunta de AndalucíaMinisterio de Ciencia e Innovación (España)López-Ayllón, Blanca D. [0000-0003-3889-3644]Lucas-Rius, Ana de [0000-0003-1920-2414]Mendoza, Laura [0000-0002-9964-8127]García-García, Tránsito [0000-0003-3708-0908]Fernández-Rodríguez, Raúl [0000-0001-8301-0244]Suárez-Cárdenas, José M. [0000-0001-8509-1498]Milhano, Fátima [0000-0002-4041-1504]Redondo, Natalia [0000-0001-9356-8102]Zaldívar-López, Sara [0000-0001-5084-8999]Jiménez-Marín, Ángeles [0000-0001-6546-9174]Garrido, Juan J. [0000-0001-6592-2231]Montoya, María [0000-0002-5703-7360]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/334280reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3389/fimmu.2023.1220306Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3342802026-05-22T06:33:51Z |
| dc.title.none.fl_str_mv |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| title |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| spellingShingle |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling López-Ayllón, Blanca D. SARS-CoV-2 Accessory proteins IL11 Lung Fibrosis COVID-19 |
| title_short |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| title_full |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| title_fullStr |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| title_full_unstemmed |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| title_sort |
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling |
| dc.creator.none.fl_str_mv |
López-Ayllón, Blanca D. Lucas-Rius, Ana de Mendoza-García, Laura García-García, Tránsito Fernández-Rodríguez, Raúl Suárez-Cárdenas, José M. Milhano, Fátima Corrales, Fernando J. Redondo, Natalia Pedrucci, Federica Zaldívar-López, Sara Jiménez-Marín, Ángeles Garrido, Juan J. Montoya, María |
| author |
López-Ayllón, Blanca D. |
| author_facet |
López-Ayllón, Blanca D. Lucas-Rius, Ana de Mendoza-García, Laura García-García, Tránsito Fernández-Rodríguez, Raúl Suárez-Cárdenas, José M. Milhano, Fátima Corrales, Fernando J. Redondo, Natalia Pedrucci, Federica Zaldívar-López, Sara Jiménez-Marín, Ángeles Garrido, Juan J. Montoya, María |
| author_role |
author |
| author2 |
Lucas-Rius, Ana de Mendoza-García, Laura García-García, Tránsito Fernández-Rodríguez, Raúl Suárez-Cárdenas, José M. Milhano, Fátima Corrales, Fernando J. Redondo, Natalia Pedrucci, Federica Zaldívar-López, Sara Jiménez-Marín, Ángeles Garrido, Juan J. Montoya, María |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission Junta de Andalucía Ministerio de Ciencia e Innovación (España) López-Ayllón, Blanca D. [0000-0003-3889-3644] Lucas-Rius, Ana de [0000-0003-1920-2414] Mendoza, Laura [0000-0002-9964-8127] García-García, Tránsito [0000-0003-3708-0908] Fernández-Rodríguez, Raúl [0000-0001-8301-0244] Suárez-Cárdenas, José M. [0000-0001-8509-1498] Milhano, Fátima [0000-0002-4041-1504] Redondo, Natalia [0000-0001-9356-8102] Zaldívar-López, Sara [0000-0001-5084-8999] Jiménez-Marín, Ángeles [0000-0001-6546-9174] Garrido, Juan J. [0000-0001-6592-2231] Montoya, María [0000-0002-5703-7360] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
SARS-CoV-2 Accessory proteins IL11 Lung Fibrosis COVID-19 |
| topic |
SARS-CoV-2 Accessory proteins IL11 Lung Fibrosis COVID-19 |
| description |
15 p.-7 fig. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/334280 |
| url |
http://hdl.handle.net/10261/334280 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
https://doi.org/10.3389/fimmu.2023.1220306 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869414982594068480 |
| score |
15.81155 |