Influence of elevated-CRP levelrelated polymorphisms in nonrheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-...

Descripción completa

Detalles Bibliográficos
Autores: López Mejías, Raquel, Genre, Fernanda, Remuzgo Martínez, Sara, González Juanatey, Carlos, Robustillo Villarino, Montserrat, Llorca Díaz, Javier, Corrales, Alfonso, Vicente, Esther F., Miranda-Filloy, José A., Magro Checa, Cesar, Tejera Segura, Beatriz, Ramírez Huaranga, Marco A., Pina, Trinitario, Blanco, Ricardo, Alegre-Sancho, Juan José, Raya, Enrique, Mijares, Verónica, Ubilla, Begoña, Mínguez Sanchez, María D., Gómez Vaquero, Carmen, Balsa, Alejandro, Pascual-Salcedo, Dora, López Longo, Francisco J., Carreira, Patricia, González Álvaro, Isidoro, Rodríguez-Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Ferraz Amaro, Iván, Castañeda, Santos, Martín, Javier, González-Gay, Miguel A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126821
Acceso en línea:https://hdl.handle.net/2445/126821
Access Level:acceso abierto
Palabra clave:Artritis reumatoide
Aterosclerosi
Rheumatoid arthritis
Atherosclerosis
Descripción
Sumario:Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.

Similares en LA Referencia