White matter integrity related to functional working memory networks in traumatic brain injury

Objective: This study explores the functional and structural patterns of connectivity underlying working memory impairment after severe traumatic axonal injury. Methods: We performed an fMRI n-back task and acquired diffusion tensor images (DTI) in a group of 19 chronic-stage patients with severe tr...

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Autores: Palacios, Eva M., Sala Llonch, Roser, Junque, Carme, Roig, Teresa, Tormos Muñoz, José María, Bargallo, Nuria, Vendrell, Pere
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/3325
Acceso en línea:http://hdl.handle.net/20.500.12466/3325
Access Level:acceso abierto
Palabra clave:Memory disorders
Traumatic brain injury
2490 Neurociencias
3207.11 Neuropatología
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spelling White matter integrity related to functional working memory networks in traumatic brain injuryPalacios, Eva M.Sala Llonch, RoserJunque, CarmeRoig, TeresaTormos Muñoz, José MaríaBargallo, NuriaVendrell, PereMemory disordersTraumatic brain injury2490 Neurociencias3207.11 NeuropatologíaObjective: This study explores the functional and structural patterns of connectivity underlying working memory impairment after severe traumatic axonal injury. Methods: We performed an fMRI n-back task and acquired diffusion tensor images (DTI) in a group of 19 chronic-stage patients with severe traumatic brain injury (TBI) and evidence of traumatic axonal injury and 19 matched healthy controls. We performed image analyses with FSL software and fMRI data were analyzed using probabilistic independent component analysis. Fractional anisotropy (FA) maps from DTI images were analyzed with FMRIB's Diffusion Toolbox. Results: We identified working memory and default mode networks. Global FA values correlated with both networks and FA whole-brain analysis revealed correlations in several tracts associated with the functional activation. Furthermore, working memory performance in the patient group correlated with the functional activation patterns and with the FA values of the associative fasciculi. Conclusion: Combining structural and functional neuroimaging data, we were able to describe structural white matter changes related to functional network alterations and to lower performance in working memory in chronic TBI.20232023-12-1920152015-02-1520152015-02-15journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/3325reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/33252026-06-19T08:32:07Z
dc.title.none.fl_str_mv White matter integrity related to functional working memory networks in traumatic brain injury
title White matter integrity related to functional working memory networks in traumatic brain injury
spellingShingle White matter integrity related to functional working memory networks in traumatic brain injury
Palacios, Eva M.
Memory disorders
Traumatic brain injury
2490 Neurociencias
3207.11 Neuropatología
title_short White matter integrity related to functional working memory networks in traumatic brain injury
title_full White matter integrity related to functional working memory networks in traumatic brain injury
title_fullStr White matter integrity related to functional working memory networks in traumatic brain injury
title_full_unstemmed White matter integrity related to functional working memory networks in traumatic brain injury
title_sort White matter integrity related to functional working memory networks in traumatic brain injury
dc.creator.none.fl_str_mv Palacios, Eva M.
Sala Llonch, Roser
Junque, Carme
Roig, Teresa
Tormos Muñoz, José María
Bargallo, Nuria
Vendrell, Pere
author Palacios, Eva M.
author_facet Palacios, Eva M.
Sala Llonch, Roser
Junque, Carme
Roig, Teresa
Tormos Muñoz, José María
Bargallo, Nuria
Vendrell, Pere
author_role author
author2 Sala Llonch, Roser
Junque, Carme
Roig, Teresa
Tormos Muñoz, José María
Bargallo, Nuria
Vendrell, Pere
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Memory disorders
Traumatic brain injury
2490 Neurociencias
3207.11 Neuropatología
topic Memory disorders
Traumatic brain injury
2490 Neurociencias
3207.11 Neuropatología
description Objective: This study explores the functional and structural patterns of connectivity underlying working memory impairment after severe traumatic axonal injury. Methods: We performed an fMRI n-back task and acquired diffusion tensor images (DTI) in a group of 19 chronic-stage patients with severe traumatic brain injury (TBI) and evidence of traumatic axonal injury and 19 matched healthy controls. We performed image analyses with FSL software and fMRI data were analyzed using probabilistic independent component analysis. Fractional anisotropy (FA) maps from DTI images were analyzed with FMRIB's Diffusion Toolbox. Results: We identified working memory and default mode networks. Global FA values correlated with both networks and FA whole-brain analysis revealed correlations in several tracts associated with the functional activation. Furthermore, working memory performance in the patient group correlated with the functional activation patterns and with the FA values of the associative fasciculi. Conclusion: Combining structural and functional neuroimaging data, we were able to describe structural white matter changes related to functional network alterations and to lower performance in working memory in chronic TBI.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-02-15
2015
2015-02-15
2023
2023-12-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/3325
url http://hdl.handle.net/20.500.12466/3325
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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