The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet

Despite the increasing evidence of links between human gut and health, the number of gut microbiomes that have been studied to date at a country level are surprisingly low. Mediterranean countries, including some of the most long-lived and healthy countries in the world, have not been considered so...

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Detalles Bibliográficos
Autores: Latorre Pérez, Adriel, Hernández, Marta, Iglesias, Jose Ramon, Moran, Javier, Pascual, Javier, Porcar, Manuel, Vilanova, Cristina, Collado, Luis, Collado Yurrita, Luis Rodolfo
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/128282
Acceso en línea:https://hdl.handle.net/20.500.14352/128282
Access Level:acceso abierto
Palabra clave:579.17:613.2
Dietética y nutrición (Medicina)
Microbiología médica
3206 Ciencias de la Nutrición
3201.03 Microbiología Clínica
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repository_id_str
spelling The Spanish gut microbiome reveals links between microorganisms and Mediterranean dietLatorre Pérez, AdrielHernández, MartaIglesias, Jose RamonMoran, JavierPascual, JavierPorcar, ManuelVilanova, CristinaCollado, LuisCollado Yurrita, Luis Rodolfo579.17:613.2Dietética y nutrición (Medicina)Microbiología médica3206 Ciencias de la Nutrición3201.03 Microbiología ClínicaDespite the increasing evidence of links between human gut and health, the number of gut microbiomes that have been studied to date at a country level are surprisingly low. Mediterranean countries, including some of the most long-lived and healthy countries in the world, have not been considered so far in those studies at a large scale. The main objective of this work is to characterize the gut microbiome of a healthy adult population of a Mediterranean, paradigmatically healthy country: Spain. Stool samples from 530 healthy volunteers were collected, total metagenomic DNA extracted, and the microbial profiles determined through 16S rRNA metataxonomic sequencing. Our results confirm the associations between several microbial markers and different variables, including sex, age, BMI and diet choices, and bring new insights into the relationship between microbiome and diet in the Spanish population. Remarkably, some of the associations found, such as the decrease of Faecalibacterium with age or the link of Flavonifractor with less healthy dietary habits, have been barely noticed in other large-scale cohorts. On the other hand, a range of links between microorganisms, diet, and lifestyle coincide with those reported in other populations, thus increasing the robustness of such associations and confirming the importance of these microbial markers across different countries. Overall, this study describes the Spanish “normal” microbiome, providing a solid baseline for future studies investigating the effects of gut microbiome composition and deviations in the adherence to the Mediterranean diet.Scientific ReportsUniversidad Complutense de Madrid20212021-11-1020212021-11-10journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/128282reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1282822026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
spellingShingle The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
Latorre Pérez, Adriel
579.17:613.2
Dietética y nutrición (Medicina)
Microbiología médica
3206 Ciencias de la Nutrición
3201.03 Microbiología Clínica
title_short The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_full The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_fullStr The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_full_unstemmed The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
title_sort The Spanish gut microbiome reveals links between microorganisms and Mediterranean diet
dc.creator.none.fl_str_mv Latorre Pérez, Adriel
Hernández, Marta
Iglesias, Jose Ramon
Moran, Javier
Pascual, Javier
Porcar, Manuel
Vilanova, Cristina
Collado, Luis
Collado Yurrita, Luis Rodolfo
author Latorre Pérez, Adriel
author_facet Latorre Pérez, Adriel
Hernández, Marta
Iglesias, Jose Ramon
Moran, Javier
Pascual, Javier
Porcar, Manuel
Vilanova, Cristina
Collado, Luis
Collado Yurrita, Luis Rodolfo
author_role author
author2 Hernández, Marta
Iglesias, Jose Ramon
Moran, Javier
Pascual, Javier
Porcar, Manuel
Vilanova, Cristina
Collado, Luis
Collado Yurrita, Luis Rodolfo
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579.17:613.2
Dietética y nutrición (Medicina)
Microbiología médica
3206 Ciencias de la Nutrición
3201.03 Microbiología Clínica
topic 579.17:613.2
Dietética y nutrición (Medicina)
Microbiología médica
3206 Ciencias de la Nutrición
3201.03 Microbiología Clínica
description Despite the increasing evidence of links between human gut and health, the number of gut microbiomes that have been studied to date at a country level are surprisingly low. Mediterranean countries, including some of the most long-lived and healthy countries in the world, have not been considered so far in those studies at a large scale. The main objective of this work is to characterize the gut microbiome of a healthy adult population of a Mediterranean, paradigmatically healthy country: Spain. Stool samples from 530 healthy volunteers were collected, total metagenomic DNA extracted, and the microbial profiles determined through 16S rRNA metataxonomic sequencing. Our results confirm the associations between several microbial markers and different variables, including sex, age, BMI and diet choices, and bring new insights into the relationship between microbiome and diet in the Spanish population. Remarkably, some of the associations found, such as the decrease of Faecalibacterium with age or the link of Flavonifractor with less healthy dietary habits, have been barely noticed in other large-scale cohorts. On the other hand, a range of links between microorganisms, diet, and lifestyle coincide with those reported in other populations, thus increasing the robustness of such associations and confirming the importance of these microbial markers across different countries. Overall, this study describes the Spanish “normal” microbiome, providing a solid baseline for future studies investigating the effects of gut microbiome composition and deviations in the adherence to the Mediterranean diet.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-11-10
2021
2021-11-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/128282
url https://hdl.handle.net/20.500.14352/128282
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Scientific Reports
publisher.none.fl_str_mv Scientific Reports
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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