Role of capsule endoscopy in suspected celiac disease: A European multi-centre study
METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atr...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/70184 |
| Acceso en línea: | https://hdl.handle.net/10171/70184 |
| Access Level: | acceso abierto |
| Palabra clave: | Anti-transglutaminase antibodies Non-celiac gluten sensitivity Capsule endoscopy Celiac disease Gluten-free diet |
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oai:dadun.unav.edu:10171/70184 |
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España |
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| dc.title.none.fl_str_mv |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| title |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| spellingShingle |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study Luján-Sanchís, M. (Marisol)|||/items/8c009c24-20a2-46ad-bc3e-fa26a4c53a2f Anti-transglutaminase antibodies Non-celiac gluten sensitivity Capsule endoscopy Celiac disease Gluten-free diet |
| title_short |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| title_full |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| title_fullStr |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| title_full_unstemmed |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| title_sort |
Role of capsule endoscopy in suspected celiac disease: A European multi-centre study |
| dc.creator.none.fl_str_mv |
Luján-Sanchís, M. (Marisol)|||/items/8c009c24-20a2-46ad-bc3e-fa26a4c53a2f Pérez-Cuadrado-Robles, E. (Enrique)|||/items/ad7e4c1d-2a75-4038-a573-2233a77f19b5 García-Lledó, J. (Javier)|||/items/b3f61ee9-6677-47e9-8715-e3d1dd2a3339 Juanmartiñena-Fernández, J.F. (José Francisco)|||/items/4ca43689-8149-4d89-8ad0-3519e85d1759 Elli, L. (Luca)|||/items/eca82439-9b9d-4864-851c-4c895f4a4d15 Jiménez-García, V. A. (Victoria Alejandra)|||/items/7e3f2d6a-ce20-4039-a0e9-9525481b1c87 Egea-Valenzuela, J. (Juan)|||/items/67d73757-f0b6-4f7a-bec2-5b1f25a0051e Valle-Muñoz, J. (Julio)|||/items/31f87865-e401-4505-b4fc-4c7dcdf87ebc Carretero-Ribón, C. (Cristina)|||/items/37f2d58e-655b-4c90-9b71-3df3c5034300 Fernandez-Urien, I. (Ignacio)|||/items/5e107899-4f41-4b1a-a507-88a1fb72be02 López-Higueras, A. (Antonio)|||/items/bccf5905-e8b8-4318-a677-5f1795844e31 Alonso-Lázaro, N. (Noelia)|||/items/f64fe7a2-ca06-4946-b4ca-736fc93f4b8a Sanjuan-Acosta, M. (Mileidis)|||/items/eb3a8d3a-e54f-453a-9c66-1ef31b3326df Sánchez-Ceballos, F. (Francisco)|||/items/5903483a-43f7-4896-9dd3-5f899da572f4 Rosa, B. (Bruno)|||/items/c0144672-4701-4e2a-8d4c-0ebe652db386 González-Vázquez, S. (Santiago)|||/items/7e850865-7d7e-43dd-94bd-4ad22f7d1fbf Branchi, F. (Federica)|||/items/82f3eea1-e683-4797-9a3f-9d9c3fc03ea8 Ruano-Díaz, L. (Lucía)|||/items/a280b1d5-c878-41b5-855a-1354e77e240b Prieto-de-Frías, C. (César)|||/items/6a3894c5-3d67-4161-9ca3-605cf1c39fcc Pons-Beltran, V. (Vicente)|||/items/143dc8fd-d622-4347-adf9-b41326e0066b Borque-Barrera, P. (Pilar)|||/items/87fc8ab0-ad9e-4d0f-a22b-b7647f20ed56 Gonzalez-Suarez, B. (Begoña)|||/items/4027436a-6930-4396-8a49-957792222755 Xavier, S. (Sofía)|||/items/6ab0bce9-043d-4f59-8edd-7ed72d4d6f59 Argüelles-Arias, F. (Federico)|||/items/cc33020e-874e-48b7-afeb-ad8ef40a46bb Herrerías-Gutiérrez, J. M. (Juan Manuel)|||/items/2d886826-6b08-40a6-883b-1bb92bde4a2b Pérez-Cuadrado-Martínez, E. (Enrique)|||/items/fdbeb9b2-fefa-418f-b7a4-9bbaf8a2eafc Sempere-García-Argüelles, J. (Javier)|||/items/4989e520-b120-40fc-a44b-fbbf77a7edf7 |
| author |
Luján-Sanchís, M. (Marisol)|||/items/8c009c24-20a2-46ad-bc3e-fa26a4c53a2f |
| author_facet |
Luján-Sanchís, M. (Marisol)|||/items/8c009c24-20a2-46ad-bc3e-fa26a4c53a2f Pérez-Cuadrado-Robles, E. (Enrique)|||/items/ad7e4c1d-2a75-4038-a573-2233a77f19b5 García-Lledó, J. (Javier)|||/items/b3f61ee9-6677-47e9-8715-e3d1dd2a3339 Juanmartiñena-Fernández, J.F. (José Francisco)|||/items/4ca43689-8149-4d89-8ad0-3519e85d1759 Elli, L. (Luca)|||/items/eca82439-9b9d-4864-851c-4c895f4a4d15 Jiménez-García, V. A. (Victoria Alejandra)|||/items/7e3f2d6a-ce20-4039-a0e9-9525481b1c87 Egea-Valenzuela, J. (Juan)|||/items/67d73757-f0b6-4f7a-bec2-5b1f25a0051e Valle-Muñoz, J. (Julio)|||/items/31f87865-e401-4505-b4fc-4c7dcdf87ebc Carretero-Ribón, C. (Cristina)|||/items/37f2d58e-655b-4c90-9b71-3df3c5034300 Fernandez-Urien, I. (Ignacio)|||/items/5e107899-4f41-4b1a-a507-88a1fb72be02 López-Higueras, A. (Antonio)|||/items/bccf5905-e8b8-4318-a677-5f1795844e31 Alonso-Lázaro, N. (Noelia)|||/items/f64fe7a2-ca06-4946-b4ca-736fc93f4b8a Sanjuan-Acosta, M. (Mileidis)|||/items/eb3a8d3a-e54f-453a-9c66-1ef31b3326df Sánchez-Ceballos, F. (Francisco)|||/items/5903483a-43f7-4896-9dd3-5f899da572f4 Rosa, B. (Bruno)|||/items/c0144672-4701-4e2a-8d4c-0ebe652db386 González-Vázquez, S. (Santiago)|||/items/7e850865-7d7e-43dd-94bd-4ad22f7d1fbf Branchi, F. (Federica)|||/items/82f3eea1-e683-4797-9a3f-9d9c3fc03ea8 Ruano-Díaz, L. (Lucía)|||/items/a280b1d5-c878-41b5-855a-1354e77e240b Prieto-de-Frías, C. (César)|||/items/6a3894c5-3d67-4161-9ca3-605cf1c39fcc Pons-Beltran, V. (Vicente)|||/items/143dc8fd-d622-4347-adf9-b41326e0066b Borque-Barrera, P. (Pilar)|||/items/87fc8ab0-ad9e-4d0f-a22b-b7647f20ed56 Gonzalez-Suarez, B. (Begoña)|||/items/4027436a-6930-4396-8a49-957792222755 Xavier, S. (Sofía)|||/items/6ab0bce9-043d-4f59-8edd-7ed72d4d6f59 Argüelles-Arias, F. (Federico)|||/items/cc33020e-874e-48b7-afeb-ad8ef40a46bb Herrerías-Gutiérrez, J. M. (Juan Manuel)|||/items/2d886826-6b08-40a6-883b-1bb92bde4a2b Pérez-Cuadrado-Martínez, E. (Enrique)|||/items/fdbeb9b2-fefa-418f-b7a4-9bbaf8a2eafc Sempere-García-Argüelles, J. (Javier)|||/items/4989e520-b120-40fc-a44b-fbbf77a7edf7 |
| author_role |
author |
| author2 |
Pérez-Cuadrado-Robles, E. (Enrique)|||/items/ad7e4c1d-2a75-4038-a573-2233a77f19b5 García-Lledó, J. (Javier)|||/items/b3f61ee9-6677-47e9-8715-e3d1dd2a3339 Juanmartiñena-Fernández, J.F. (José Francisco)|||/items/4ca43689-8149-4d89-8ad0-3519e85d1759 Elli, L. (Luca)|||/items/eca82439-9b9d-4864-851c-4c895f4a4d15 Jiménez-García, V. A. (Victoria Alejandra)|||/items/7e3f2d6a-ce20-4039-a0e9-9525481b1c87 Egea-Valenzuela, J. (Juan)|||/items/67d73757-f0b6-4f7a-bec2-5b1f25a0051e Valle-Muñoz, J. (Julio)|||/items/31f87865-e401-4505-b4fc-4c7dcdf87ebc Carretero-Ribón, C. (Cristina)|||/items/37f2d58e-655b-4c90-9b71-3df3c5034300 Fernandez-Urien, I. (Ignacio)|||/items/5e107899-4f41-4b1a-a507-88a1fb72be02 López-Higueras, A. (Antonio)|||/items/bccf5905-e8b8-4318-a677-5f1795844e31 Alonso-Lázaro, N. (Noelia)|||/items/f64fe7a2-ca06-4946-b4ca-736fc93f4b8a Sanjuan-Acosta, M. (Mileidis)|||/items/eb3a8d3a-e54f-453a-9c66-1ef31b3326df Sánchez-Ceballos, F. (Francisco)|||/items/5903483a-43f7-4896-9dd3-5f899da572f4 Rosa, B. (Bruno)|||/items/c0144672-4701-4e2a-8d4c-0ebe652db386 González-Vázquez, S. (Santiago)|||/items/7e850865-7d7e-43dd-94bd-4ad22f7d1fbf Branchi, F. (Federica)|||/items/82f3eea1-e683-4797-9a3f-9d9c3fc03ea8 Ruano-Díaz, L. (Lucía)|||/items/a280b1d5-c878-41b5-855a-1354e77e240b Prieto-de-Frías, C. (César)|||/items/6a3894c5-3d67-4161-9ca3-605cf1c39fcc Pons-Beltran, V. (Vicente)|||/items/143dc8fd-d622-4347-adf9-b41326e0066b Borque-Barrera, P. (Pilar)|||/items/87fc8ab0-ad9e-4d0f-a22b-b7647f20ed56 Gonzalez-Suarez, B. (Begoña)|||/items/4027436a-6930-4396-8a49-957792222755 Xavier, S. (Sofía)|||/items/6ab0bce9-043d-4f59-8edd-7ed72d4d6f59 Argüelles-Arias, F. (Federico)|||/items/cc33020e-874e-48b7-afeb-ad8ef40a46bb Herrerías-Gutiérrez, J. M. (Juan Manuel)|||/items/2d886826-6b08-40a6-883b-1bb92bde4a2b Pérez-Cuadrado-Martínez, E. (Enrique)|||/items/fdbeb9b2-fefa-418f-b7a4-9bbaf8a2eafc Sempere-García-Argüelles, J. (Javier)|||/items/4989e520-b120-40fc-a44b-fbbf77a7edf7 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Anti-transglutaminase antibodies Non-celiac gluten sensitivity Capsule endoscopy Celiac disease Gluten-free diet |
| topic |
Anti-transglutaminase antibodies Non-celiac gluten sensitivity Capsule endoscopy Celiac disease Gluten-free diet |
| description |
METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were analysed. RESULTS The overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD. CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-01-01 2017 2017-01-01 2024 2024-10-17 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/70184 |
| url |
https://hdl.handle.net/10171/70184 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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| repository.mail.fl_str_mv |
|
| _version_ |
1869414849726906368 |
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Role of capsule endoscopy in suspected celiac disease: A European multi-centre studyLuján-Sanchís, M. (Marisol)|||/items/8c009c24-20a2-46ad-bc3e-fa26a4c53a2fPérez-Cuadrado-Robles, E. (Enrique)|||/items/ad7e4c1d-2a75-4038-a573-2233a77f19b5García-Lledó, J. (Javier)|||/items/b3f61ee9-6677-47e9-8715-e3d1dd2a3339Juanmartiñena-Fernández, J.F. (José Francisco)|||/items/4ca43689-8149-4d89-8ad0-3519e85d1759Elli, L. (Luca)|||/items/eca82439-9b9d-4864-851c-4c895f4a4d15Jiménez-García, V. A. (Victoria Alejandra)|||/items/7e3f2d6a-ce20-4039-a0e9-9525481b1c87Egea-Valenzuela, J. (Juan)|||/items/67d73757-f0b6-4f7a-bec2-5b1f25a0051eValle-Muñoz, J. (Julio)|||/items/31f87865-e401-4505-b4fc-4c7dcdf87ebcCarretero-Ribón, C. (Cristina)|||/items/37f2d58e-655b-4c90-9b71-3df3c5034300Fernandez-Urien, I. (Ignacio)|||/items/5e107899-4f41-4b1a-a507-88a1fb72be02López-Higueras, A. (Antonio)|||/items/bccf5905-e8b8-4318-a677-5f1795844e31Alonso-Lázaro, N. (Noelia)|||/items/f64fe7a2-ca06-4946-b4ca-736fc93f4b8aSanjuan-Acosta, M. (Mileidis)|||/items/eb3a8d3a-e54f-453a-9c66-1ef31b3326dfSánchez-Ceballos, F. (Francisco)|||/items/5903483a-43f7-4896-9dd3-5f899da572f4Rosa, B. (Bruno)|||/items/c0144672-4701-4e2a-8d4c-0ebe652db386González-Vázquez, S. (Santiago)|||/items/7e850865-7d7e-43dd-94bd-4ad22f7d1fbfBranchi, F. (Federica)|||/items/82f3eea1-e683-4797-9a3f-9d9c3fc03ea8Ruano-Díaz, L. (Lucía)|||/items/a280b1d5-c878-41b5-855a-1354e77e240bPrieto-de-Frías, C. (César)|||/items/6a3894c5-3d67-4161-9ca3-605cf1c39fccPons-Beltran, V. (Vicente)|||/items/143dc8fd-d622-4347-adf9-b41326e0066bBorque-Barrera, P. (Pilar)|||/items/87fc8ab0-ad9e-4d0f-a22b-b7647f20ed56Gonzalez-Suarez, B. (Begoña)|||/items/4027436a-6930-4396-8a49-957792222755Xavier, S. (Sofía)|||/items/6ab0bce9-043d-4f59-8edd-7ed72d4d6f59Argüelles-Arias, F. (Federico)|||/items/cc33020e-874e-48b7-afeb-ad8ef40a46bbHerrerías-Gutiérrez, J. M. (Juan Manuel)|||/items/2d886826-6b08-40a6-883b-1bb92bde4a2bPérez-Cuadrado-Martínez, E. (Enrique)|||/items/fdbeb9b2-fefa-418f-b7a4-9bbaf8a2eafcSempere-García-Argüelles, J. (Javier)|||/items/4989e520-b120-40fc-a44b-fbbf77a7edf7Anti-transglutaminase antibodiesNon-celiac gluten sensitivityCapsule endoscopyCeliac diseaseGluten-free dietMETHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were analysed. RESULTS The overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD. CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD.Dadun. Depósito Académico Digital Universidad de Navarra20242024-10-1720172017-01-0120172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/70184reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/701842026-06-21T12:47:57Z |
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15,812429 |