Challenges to drug discovery for celiac disease and approaches to overcome them

[Introduction] The only available effective treatment for celiac disease (CD) is strict and long-term compliance with a gluten-free diet. Dietary gluten restriction must be strict and long term, but is difficult to achieve in many cases and alternative dietary strategies have been investigated in th...

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Detalles Bibliográficos
Autores: Vaquero, Luis, Bernardo, David, León, Francisco, Rodríguez-Martín, Laura, Álvarez-Cuenllas, Begoña, Vivas, Santiago
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/196417
Acceso en línea:http://hdl.handle.net/10261/196417
Access Level:acceso abierto
Palabra clave:Celiac disease
Intestinal permeability
Gluten tolerance
Tissue transglutaminase
Immunomodulation
Proteases
Descripción
Sumario:[Introduction] The only available effective treatment for celiac disease (CD) is strict and long-term compliance with a gluten-free diet. Dietary gluten restriction must be strict and long term, but is difficult to achieve in many cases and alternative dietary strategies have been investigated in the past few years.