GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway

[Introduction]: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reduc...

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Detalles Bibliográficos
Autores: Jurado-Aguilar, Javier, Barroso, Emma, Bernard, Maribel, Zhang, Meijian, Peyman, Mona, Rada, Patricia, Valverde, Ángela M., Wahli, Walter, Palomer, Xavier, Vázquez-Carrera, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363456
Acceso en línea:http://hdl.handle.net/10261/363456
Access Level:acceso abierto
Palabra clave:GDF15
AMPK
SMAD3
TGF-β
Gluconeogenesis
Fibrosis
Descripción
Sumario:[Introduction]: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reducing food intake through its hindbrain receptor GFRAL.

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