GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway

[Introduction]: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reduc...

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Detalhes bibliográficos
Autores: Jurado-Aguilar, Javier, Barroso, Emma, Bernard, Maribel, Zhang, Meijian, Peyman, Mona, Rada, Patricia, Valverde, Ángela M., Wahli, Walter, Palomer, Xavier, Vázquez-Carrera, Manuel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/363456
Acesso em linha:http://hdl.handle.net/10261/363456
Access Level:Acceso aberto
Palavra-chave:GDF15
AMPK
SMAD3
TGF-β
Gluconeogenesis
Fibrosis
Descrição
Resumo:[Introduction]: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF15). This stress response cytokine regulates energy metabolism mainly by reducing food intake through its hindbrain receptor GFRAL.

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