Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study

Aims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after 18 months of intervention. Methods: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18–24 months were randomly allocated by trial...

Descripción completa

Detalles Bibliográficos
Autores: Laosa, Olga, Topinkova, Eva, Bourdel Marchasson, Isabelle, Vellas, Bruno, Izquierdo Redín, Mikel, Paolisso, Giuseppe, Hardman, Timothy C., Zeyfang, Andrej, Pedraza, Laura, Carnicero Carreño, José Antonio, Rodríguez Mañas, Leocadio, Sinclair, Alan J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/53809
Acceso en línea:https://hdl.handle.net/2454/53809
Access Level:acceso abierto
Palabra clave:Frailty
Older people
Diabetes
Clinical trial
Functional impairment
id ES_9e44c847df0d7c7c03e4b5a5b88db8bb
oai_identifier_str oai:academica-e.unavarra.es:2454/53809
network_acronym_str ES
network_name_str España
repository_id_str
spelling Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical studyLaosa, OlgaTopinkova, EvaBourdel Marchasson, IsabelleVellas, BrunoIzquierdo Redín, MikelPaolisso, GiuseppeHardman, Timothy C.Zeyfang, AndrejPedraza, LauraCarnicero Carreño, José AntonioRodríguez Mañas, LeocadioSinclair, Alan J.FrailtyOlder peopleDiabetesClinical trialFunctional impairmentAims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after 18 months of intervention. Methods: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18–24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). Results: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried’s frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3–5.4; p = 0.009 and OR 1.9; 95%CI 1.1 3.1; p = 0.02, respectively). IG participants more frequently improved 1 point in SPPB score (OR 1.85; 95%CI 1.09–3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. Conclusions: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.This research was supported by European Commission, 7th Framework Programme (Contract No 278803) and CIBERFES (CB16/10/00464).ElsevierCiencias de la SaludOsasun Zientziak2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/mswordhttps://hdl.handle.net/2454/53809reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/European Commission/FP7/278803© 2025 Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY-NC-ND license.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/538092026-06-17T12:41:47Z
dc.title.none.fl_str_mv Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
title Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
spellingShingle Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
Laosa, Olga
Frailty
Older people
Diabetes
Clinical trial
Functional impairment
title_short Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
title_full Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
title_fullStr Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
title_full_unstemmed Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
title_sort Long-term frailty and physical performance transitions in older people with type-2 diabetes: the MIDFRAIL randomized clinical study
dc.creator.none.fl_str_mv Laosa, Olga
Topinkova, Eva
Bourdel Marchasson, Isabelle
Vellas, Bruno
Izquierdo Redín, Mikel
Paolisso, Giuseppe
Hardman, Timothy C.
Zeyfang, Andrej
Pedraza, Laura
Carnicero Carreño, José Antonio
Rodríguez Mañas, Leocadio
Sinclair, Alan J.
author Laosa, Olga
author_facet Laosa, Olga
Topinkova, Eva
Bourdel Marchasson, Isabelle
Vellas, Bruno
Izquierdo Redín, Mikel
Paolisso, Giuseppe
Hardman, Timothy C.
Zeyfang, Andrej
Pedraza, Laura
Carnicero Carreño, José Antonio
Rodríguez Mañas, Leocadio
Sinclair, Alan J.
author_role author
author2 Topinkova, Eva
Bourdel Marchasson, Isabelle
Vellas, Bruno
Izquierdo Redín, Mikel
Paolisso, Giuseppe
Hardman, Timothy C.
Zeyfang, Andrej
Pedraza, Laura
Carnicero Carreño, José Antonio
Rodríguez Mañas, Leocadio
Sinclair, Alan J.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Osasun Zientziak
dc.subject.none.fl_str_mv Frailty
Older people
Diabetes
Clinical trial
Functional impairment
topic Frailty
Older people
Diabetes
Clinical trial
Functional impairment
description Aims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after 18 months of intervention. Methods: 298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18–24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). Results: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried’s frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3–5.4; p = 0.009 and OR 1.9; 95%CI 1.1 3.1; p = 0.02, respectively). IG participants more frequently improved 1 point in SPPB score (OR 1.85; 95%CI 1.09–3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. Conclusions: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/53809
url https://hdl.handle.net/2454/53809
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/European Commission/FP7/278803
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/msword
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414812755165184
score 15,811543

Similares en LA Referencia