Efficacy of a Multicomponent Intervention for Frailty or Physical Function in Prefrail or Frail Older Adults: FRAILMERIT Multicenter Clinical Trial

Objectives Frailty is a common condition in community-dwelling older adults with high health and socioeconomic implications. However, primary care-led randomized trials have been scarcely tested. Design Multicenter cluster randomized clinical trial. Setting and Participants Two hundred and seventy-t...

Descripción completa

Detalles Bibliográficos
Autores: Abizanda Saro, Adriana, García Molina, Rafael, Alcantud Córcoles, Rubén, Maestre Moreno, Manuel, Sánchez Uceda, Raúl, Morón Merchante, Ignacio, Aragonés Jiménez, Antonio, González Céspedes, María Dolores, Montero Alía, Pilar, Simarro Rueda, Marta, Torres Antón, Luis, Martínez García, Pilar, Soriano Fernández, Humberto, Córcoles García, Marta, Reyes Abreu, Ángel Moisés, Morcillo González, María Nuria, García Páez, Elena, Rodríguez Sánchez, Beatriz, Sáez Blesa, Marta, Cortés Zamora, Elisa Belén, Andrés Pretel, Fernando, Avendaño Céspedes, Almudena, Grupo de Estudio FRAILMERIT (FRAILMERIT Study Group), Abizanda Soler, Pedro, Ruiz Grao, Marta Carolina, CB16/10/00408
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/47066
Acceso en línea:https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.70266
https://hdl.handle.net/10578/47066
Access Level:acceso abierto
Palabra clave:Exercise
Frailty
Nutrition
Older adults
Physical function
Primary care
Randomized clinical trial
Descripción
Sumario:Objectives Frailty is a common condition in community-dwelling older adults with high health and socioeconomic implications. However, primary care-led randomized trials have been scarcely tested. Design Multicenter cluster randomized clinical trial. Setting and Participants Two hundred and seventy-three community-dwelling older adults recruited from 12 Spanish primary care centers. Inclusion criteria: independence in basic activities of daily living and either prefrailty/frailty using the frailty phenotype or gait speed < 0.8 m/s. Methods Participants were randomized 1:1 by clusters to the intervention or the control group, each cluster being a different primary care center. Intervention: Physical exercise program, nutritional recommendations, and frailty training to primary care professionals. Interventions were conducted based on the guidelines of the “Consensus document on the prevention of frailty in older adults,” updated in 2022, from the Spanish Health Ministry. Control: Usual care. Main outcome: Improvement in one category of the frailty phenotype or one point in the Short Physical Performance Battery (SPPB) at 12 and 32 weeks. under Intention-to-treat analysis was conducted. Results Mean age 78.1 years, 68.4% female. 25.7% were frail and 74.3% prefrail or with a gait speed lower than 0.8 m/s. The percentage of participants improving the main outcome at week 12 for the intervention and control groups were 70.4% and 49.5%, respectively, absolute risk reduction (ARR) 20.9% (95% confidence interval [CI] 7.3%–34.5%; p < 0.01; n = 191), number needed to treat (NNT) 4.8 (95% CI 2.9–13.6). At 32 weeks of follow-up 81.7% and 51.9% of the intervention and control group improved, respectively, ARR 29.8% (95% CI 13.8%–45.7%; p < 0.001; n = 134), NNT 3.4 (95% CI 2.2–7.2). Conclusions and Implications A primary care-led intervention consisting of a physical exercise program, nutritional recommendations, and training in frailty was feasible and effective for improving frailty status or physical function in community-dwelling older adults with prefrailty or frailty. Trial Registration: clinicaltrial.gov: NCT05002439 (18/JUN/2021)

Similares en LA Referencia