Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study

[Background/Objectives]: The main objective of this study was to examine the association between lifestyle patterns (physical activity, screen and sleep time and diet) and abdominal obesity, and endocrine, metabolic, and immunological biomarkers in adolescents with Down syndrome (DS).

Detalles Bibliográficos
Autores: Gutiérrez-Hervás, Ana, Nova, Esther, Izquierdo-Gómez, Rocío, Veiga, Óscar, Padilla-Moledo, Carmen, Castro-Piñero, José, Marcos, Ascensión, Gómez-Martínez, Sonia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/373618
Acceso en línea:http://hdl.handle.net/10261/373618
Access Level:acceso abierto
Palabra clave:Down syndrome
Adolescents
Inflammatory biomarkers
Lifestyle patterns
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spelling Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN studyGutiérrez-Hervás, AnaNova, EstherIzquierdo-Gómez, RocíoVeiga, ÓscarPadilla-Moledo, CarmenCastro-Piñero, JoséMarcos, AscensiónGómez-Martínez, SoniaDown syndromeAdolescentsInflammatory biomarkersLifestyle patterns[Background/Objectives]: The main objective of this study was to examine the association between lifestyle patterns (physical activity, screen and sleep time and diet) and abdominal obesity, and endocrine, metabolic, and immunological biomarkers in adolescents with Down syndrome (DS).[Methods]: Eighty-three DS adolescents (38.6% girls), aged 11 to 18 years, from the UP&DOWN study were included. Cluster analysis was performed by including the compliance of recommendations of lifestyle variables, such as moderate to vigorous physical activity (MVPA), screen and sleep time and adherence to the Mediterranean diet (AMD). The waist-to-height ratio was used as an indicator of abdominal obesity. Haematological, biochemical and inflammatory biomarkers were analysed.[Results]: A three-cluster solution was identified: Cluster 1: adolescents with low compliance; Cluster 2: youth with medium compliance; and Cluster 3: adolescents with high compliance. Significant differences in MVPA (p = 0.000), screen time (p = 0.004), sleep time (p = 0.0001), AMD (p = 0.000) and abdominal obesity (p = 0.003) were found. Clusters 2 and 3 had lower levels of triglycerides and LDL-cholesterol than Cluster 1. Cluster 2, in which all adolescents met the MVPA recommendations, had the lowest levels of galactin 3.[Conclusions]: Compliance with lifestyle recommendations (PA, screen and sleep time and AMD) and the absence of abdominal obesity seem to be associated with better biochemical and inflammatory values.We appreciate the following financial support: DEP 2010-21662-C04-00 grants from the National Plan for Research, Development and Innovation (R + D + i) MICINN.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/373618reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//DEP2010-21662-C04-00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/nu16223884https://doi.org/10.3390/nu16223884Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3736182026-05-22T06:33:51Z
dc.title.none.fl_str_mv Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
title Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
spellingShingle Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
Gutiérrez-Hervás, Ana
Down syndrome
Adolescents
Inflammatory biomarkers
Lifestyle patterns
title_short Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
title_full Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
title_fullStr Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
title_full_unstemmed Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
title_sort Association between lifestyle patterns and abdominal obesity with biochemical and inflammatory biomarkers in adolescents with Down syndrome: The UP&DOWN study
dc.creator.none.fl_str_mv Gutiérrez-Hervás, Ana
Nova, Esther
Izquierdo-Gómez, Rocío
Veiga, Óscar
Padilla-Moledo, Carmen
Castro-Piñero, José
Marcos, Ascensión
Gómez-Martínez, Sonia
author Gutiérrez-Hervás, Ana
author_facet Gutiérrez-Hervás, Ana
Nova, Esther
Izquierdo-Gómez, Rocío
Veiga, Óscar
Padilla-Moledo, Carmen
Castro-Piñero, José
Marcos, Ascensión
Gómez-Martínez, Sonia
author_role author
author2 Nova, Esther
Izquierdo-Gómez, Rocío
Veiga, Óscar
Padilla-Moledo, Carmen
Castro-Piñero, José
Marcos, Ascensión
Gómez-Martínez, Sonia
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Down syndrome
Adolescents
Inflammatory biomarkers
Lifestyle patterns
topic Down syndrome
Adolescents
Inflammatory biomarkers
Lifestyle patterns
description [Background/Objectives]: The main objective of this study was to examine the association between lifestyle patterns (physical activity, screen and sleep time and diet) and abdominal obesity, and endocrine, metabolic, and immunological biomarkers in adolescents with Down syndrome (DS).
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/373618
url http://hdl.handle.net/10261/373618
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//DEP2010-21662-C04-00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/nu16223884
https://doi.org/10.3390/nu16223884
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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