Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial

Introduction and objectives: There is limited data on the impact of the culprit vessel on very long-term outcomes after ST-elevation myocardial infarction (STEMI). The aim was to analyze the impact of the left anterior descending coronary artery (LAD) as the culprit vessel of STEMI on very long-term...

Descripción completa

Detalles Bibliográficos
Autores: Vidal-Calés, P, Bujak, K, Rinaldi, R, Salazar-Rodríguez, A, Ortega-Paz, L, Gómez-Lara, J, Jiménez-Díaz, V, Jiménez, M, Jiménez-Quevedo, P, Diletti, R, Bordes, P, Campo, G, Silvestro, A, Maristany, J, Flores, X, De Miguel-Castro, A, Iñiguez, A, Ielasi, A, Tespili, M, Lenzen, M, Gonzalo, N, Tebaldi, M, Biscaglia, S, Romaguera, R, Gómez-Hospital, JA, Serruys, PW, Sabaté, M, Brugaletta, S
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11016
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones11016
https://recintervcardiol.org/images/pdf-files/RECIC_24_060_AO_Brugaletta_UK_13_12.pdf
Access Level:acceso abierto
Palabra clave:Acute myocardial infarction
STEMI
Angiography
Coronary
Percutaneous coronary intervention
id ES_9dbcfede404e17c9ff3e07ccdc682fa1
oai_identifier_str oai:isabial.fundanetsuite.com:p11016
network_acronym_str ES
network_name_str España
repository_id_str
spelling Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trialVidal-Calés, PBujak, KRinaldi, RSalazar-Rodríguez, AOrtega-Paz, LGómez-Lara, JJiménez-Díaz, VJiménez, MJiménez-Quevedo, PDiletti, RBordes, PCampo, GSilvestro, AMaristany, JFlores, XDe Miguel-Castro, AIñiguez, AIelasi, ATespili, MLenzen, MGonzalo, NTebaldi, MBiscaglia, SRomaguera, RGómez-Hospital, JASerruys, PWSabaté, MBrugaletta, SAcute myocardial infarctionSTEMIAngiographyCoronaryPercutaneous coronary interventionIntroduction and objectives: There is limited data on the impact of the culprit vessel on very long-term outcomes after ST-elevation myocardial infarction (STEMI). The aim was to analyze the impact of the left anterior descending coronary artery (LAD) as the culprit vessel of STEMI on very long-term outcomes. Methods: We analyzed patients included in the EXAMINATION-EXTEND study (NCT04462315) treated with everolimus-eluting stents or bare-metal stents after STEMI (1498 patients) and stratified according to the culprit vessel (LAD vs other vessels). The primary endpoint was the patient-oriented composite endpoint (POCE), including all-cause mortality, myocardial infarction (MI) or revascularization at 10 years. Secondary endpoints were individual components of POCE, device-oriented composite endpoint and its individual components and stent thrombosis. We performed landmark analyses at 1 and 5 years. All endpoints were adjusted with multivariable Cox regression models. Results: The LAD was the culprit vessel in 631 (42%) out of 1498 patients. The LAD-STEMI group had more smokers, advanced Killip class and worse left ventricular ejection fraction. Conversely, non-LAD-STEMI group showed more peripheral vascular disease, previous MI, or previous PCI. At 10 years, no differences were observed between groups regarding POCE (34.9% vs 35.4%; adjusted hazard ratio [HR], 0.95; 95% confidence interval [95%CI], 0.79-1.13; P = . 56) or other endpoints. The all-cause mortality rate was higher in the LAD-STEMI group ( P = . 041) at 1-year. Conclusions: In a contemporary cohort of STEMI patients, there were no differences in POCE between LAD as the STEMI-related culprit vessel and other vessels at 10 years follow-up. However, all-cause mortality was more common in the LAD-STEMI group within the first year after STEMI.PERMANYER PUBL2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones11016https://recintervcardiol.org/images/pdf-files/RECIC_24_060_AO_Brugaletta_UK_13_12.pdfREC-Interventional CardiologyISSN: 26047306ISSNe: 26047276reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p110162026-06-12T10:20:37Z
dc.title.none.fl_str_mv Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
title Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
spellingShingle Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
Vidal-Calés, P
Acute myocardial infarction
STEMI
Angiography
Coronary
Percutaneous coronary intervention
title_short Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
title_full Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
title_fullStr Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
title_full_unstemmed Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
title_sort Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
dc.creator.none.fl_str_mv Vidal-Calés, P
Bujak, K
Rinaldi, R
Salazar-Rodríguez, A
Ortega-Paz, L
Gómez-Lara, J
Jiménez-Díaz, V
Jiménez, M
Jiménez-Quevedo, P
Diletti, R
Bordes, P
Campo, G
Silvestro, A
Maristany, J
Flores, X
De Miguel-Castro, A
Iñiguez, A
Ielasi, A
Tespili, M
Lenzen, M
Gonzalo, N
Tebaldi, M
Biscaglia, S
Romaguera, R
Gómez-Hospital, JA
Serruys, PW
Sabaté, M
Brugaletta, S
author Vidal-Calés, P
author_facet Vidal-Calés, P
Bujak, K
Rinaldi, R
Salazar-Rodríguez, A
Ortega-Paz, L
Gómez-Lara, J
Jiménez-Díaz, V
Jiménez, M
Jiménez-Quevedo, P
Diletti, R
Bordes, P
Campo, G
Silvestro, A
Maristany, J
Flores, X
De Miguel-Castro, A
Iñiguez, A
Ielasi, A
Tespili, M
Lenzen, M
Gonzalo, N
Tebaldi, M
Biscaglia, S
Romaguera, R
Gómez-Hospital, JA
Serruys, PW
Sabaté, M
Brugaletta, S
author_role author
author2 Bujak, K
Rinaldi, R
Salazar-Rodríguez, A
Ortega-Paz, L
Gómez-Lara, J
Jiménez-Díaz, V
Jiménez, M
Jiménez-Quevedo, P
Diletti, R
Bordes, P
Campo, G
Silvestro, A
Maristany, J
Flores, X
De Miguel-Castro, A
Iñiguez, A
Ielasi, A
Tespili, M
Lenzen, M
Gonzalo, N
Tebaldi, M
Biscaglia, S
Romaguera, R
Gómez-Hospital, JA
Serruys, PW
Sabaté, M
Brugaletta, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute myocardial infarction
STEMI
Angiography
Coronary
Percutaneous coronary intervention
topic Acute myocardial infarction
STEMI
Angiography
Coronary
Percutaneous coronary intervention
description Introduction and objectives: There is limited data on the impact of the culprit vessel on very long-term outcomes after ST-elevation myocardial infarction (STEMI). The aim was to analyze the impact of the left anterior descending coronary artery (LAD) as the culprit vessel of STEMI on very long-term outcomes. Methods: We analyzed patients included in the EXAMINATION-EXTEND study (NCT04462315) treated with everolimus-eluting stents or bare-metal stents after STEMI (1498 patients) and stratified according to the culprit vessel (LAD vs other vessels). The primary endpoint was the patient-oriented composite endpoint (POCE), including all-cause mortality, myocardial infarction (MI) or revascularization at 10 years. Secondary endpoints were individual components of POCE, device-oriented composite endpoint and its individual components and stent thrombosis. We performed landmark analyses at 1 and 5 years. All endpoints were adjusted with multivariable Cox regression models. Results: The LAD was the culprit vessel in 631 (42%) out of 1498 patients. The LAD-STEMI group had more smokers, advanced Killip class and worse left ventricular ejection fraction. Conversely, non-LAD-STEMI group showed more peripheral vascular disease, previous MI, or previous PCI. At 10 years, no differences were observed between groups regarding POCE (34.9% vs 35.4%; adjusted hazard ratio [HR], 0.95; 95% confidence interval [95%CI], 0.79-1.13; P = . 56) or other endpoints. The all-cause mortality rate was higher in the LAD-STEMI group ( P = . 041) at 1-year. Conclusions: In a contemporary cohort of STEMI patients, there were no differences in POCE between LAD as the STEMI-related culprit vessel and other vessels at 10 years follow-up. However, all-cause mortality was more common in the LAD-STEMI group within the first year after STEMI.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones11016
https://recintervcardiol.org/images/pdf-files/RECIC_24_060_AO_Brugaletta_UK_13_12.pdf
url https://isabial.portalinvestigacion.com/publicaciones11016
https://recintervcardiol.org/images/pdf-files/RECIC_24_060_AO_Brugaletta_UK_13_12.pdf
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv PERMANYER PUBL
publisher.none.fl_str_mv PERMANYER PUBL
dc.source.none.fl_str_mv REC-Interventional Cardiology
ISSN: 26047306
ISSNe: 26047276
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414768022913024
score 15.811543

Similares en LA Referencia