Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.

Díaz-González Á; Molera C; Gómez-Domínguez E; Muñoz-Bartolo G; Ampuero J; Fernández-Rodríguez C; Quintero J; Molina E; Salcedo M; Olveira A; Morillas R; Díez MA; Casado M; García-Buey L; Rodríguez-Tajes S; Jorquera F; Berenguer M; Montero JL; Londoño MC

Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.

Cholestatic liver diseases comprise a heterogeneous group of disorders affecting both adult and pediatric population, characterized by alterations in bile formation, secretion, or flow, leading to the accumulation of bile acids and other toxic substances in the liver. In recent years, advances in ne...

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Autores:	Díaz-González Á, Molera C, Gómez-Domínguez E, Muñoz-Bartolo G, Ampuero J, Fernández-Rodríguez C, Quintero J, Molina E, Salcedo M, Olveira A, Morillas R, Díez MA, Casado M, García-Buey L, Rodríguez-Tajes S, Jorquera F, Berenguer M, Montero JL, Londoño MC
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2026
País:	España
Institución:	Fundació Sant Joan de Déu
Repositorio:	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:	oai:dnet:r-fsjd______::aa235e7a258041e3d5df21c4fd6bc50c
Acceso en línea:	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29432
Access Level:	acceso abierto
Palabra clave:	Cholestasis Colangitis biliar primaria Colangitis esclerosante primaria Colestasis Colestasis genética Genetic cholestasis Guidelines Guías Primary biliary cholangitis Primary sclerosing cholangitis

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spelling	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.Díaz-González ÁMolera CGómez-Domínguez EMuñoz-Bartolo GAmpuero JFernández-Rodríguez CQuintero JMolina ESalcedo MOlveira AMorillas RDíez MACasado MGarcía-Buey LRodríguez-Tajes SJorquera FBerenguer MMontero JLLondoño MCCholestasisColangitis biliar primariaColangitis esclerosante primariaColestasisColestasis genéticaGenetic cholestasisGuidelinesGuíasPrimary biliary cholangitisPrimary sclerosing cholangitisCholestatic liver diseases comprise a heterogeneous group of disorders affecting both adult and pediatric population, characterized by alterations in bile formation, secretion, or flow, leading to the accumulation of bile acids and other toxic substances in the liver. In recent years, advances in new pharmacological therapies, the availability of next-generation genetic sequencing techniques, and the development of specific treatments for genetic cholestasis have transformed the diagnostic and therapeutic approach to these conditions. This document, jointly prepared by the "Asociación Española para el Estudio del Hígado" (AEEH) and the "Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica" (SEGHNP), presents a national evidence-based guideline for the diagnosis and management of hepatic cholestasis in Spain. It addresses recommendations for differential diagnosis, diagnostic algorithms, indications for genetic studies, treatment and follow-up criteria in diseases such as primary biliary cholangitis, primary sclerosing cholangitis, genetic cholestasis, intrahepatic cholestasis of pregnancy, and vanishing bile duct syndrome. In addition, recommendations are included for the management of extrahepatic complications, indications for liver transplantation, and special considerations in pregnancy and childhood. The guideline emphasizes the importance of a multidisciplinary approach, the use of non-invasive tools for risk stratification, and the incorporation of new targeted therapies, with the aim of improving the prognosis and quality of life of patients affected by cholestatic liver diseases.ELSEVIER ESPANA SLU2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29432Gastroenterologia y HepatologiaISSN: 02105705reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuEspañolinfo:eu-repo/semantics/openAccessoai:dnet:r-fsjd______::aa235e7a258041e3d5df21c4fd6bc50c2026-05-27T12:37:41Z
dc.title.none.fl_str_mv	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
title	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
spellingShingle	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP. Díaz-González Á Cholestasis Colangitis biliar primaria Colangitis esclerosante primaria Colestasis Colestasis genética Genetic cholestasis Guidelines Guías Primary biliary cholangitis Primary sclerosing cholangitis
title_short	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
title_full	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
title_fullStr	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
title_full_unstemmed	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
title_sort	Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.
dc.creator.none.fl_str_mv	Díaz-González Á Molera C Gómez-Domínguez E Muñoz-Bartolo G Ampuero J Fernández-Rodríguez C Quintero J Molina E Salcedo M Olveira A Morillas R Díez MA Casado M García-Buey L Rodríguez-Tajes S Jorquera F Berenguer M Montero JL Londoño MC
author	Díaz-González Á
author_facet	Díaz-González Á Molera C Gómez-Domínguez E Muñoz-Bartolo G Ampuero J Fernández-Rodríguez C Quintero J Molina E Salcedo M Olveira A Morillas R Díez MA Casado M García-Buey L Rodríguez-Tajes S Jorquera F Berenguer M Montero JL Londoño MC
author_role	author
author2	Molera C Gómez-Domínguez E Muñoz-Bartolo G Ampuero J Fernández-Rodríguez C Quintero J Molina E Salcedo M Olveira A Morillas R Díez MA Casado M García-Buey L Rodríguez-Tajes S Jorquera F Berenguer M Montero JL Londoño MC
author2_role	author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Cholestasis Colangitis biliar primaria Colangitis esclerosante primaria Colestasis Colestasis genética Genetic cholestasis Guidelines Guías Primary biliary cholangitis Primary sclerosing cholangitis
topic	Cholestasis Colangitis biliar primaria Colangitis esclerosante primaria Colestasis Colestasis genética Genetic cholestasis Guidelines Guías Primary biliary cholangitis Primary sclerosing cholangitis
description	Cholestatic liver diseases comprise a heterogeneous group of disorders affecting both adult and pediatric population, characterized by alterations in bile formation, secretion, or flow, leading to the accumulation of bile acids and other toxic substances in the liver. In recent years, advances in new pharmacological therapies, the availability of next-generation genetic sequencing techniques, and the development of specific treatments for genetic cholestasis have transformed the diagnostic and therapeutic approach to these conditions. This document, jointly prepared by the "Asociación Española para el Estudio del Hígado" (AEEH) and the "Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica" (SEGHNP), presents a national evidence-based guideline for the diagnosis and management of hepatic cholestasis in Spain. It addresses recommendations for differential diagnosis, diagnostic algorithms, indications for genetic studies, treatment and follow-up criteria in diseases such as primary biliary cholangitis, primary sclerosing cholangitis, genetic cholestasis, intrahepatic cholestasis of pregnancy, and vanishing bile duct syndrome. In addition, recommendations are included for the management of extrahepatic complications, indications for liver transplantation, and special considerations in pregnancy and childhood. The guideline emphasizes the importance of a multidisciplinary approach, the use of non-invasive tools for risk stratification, and the incorporation of new targeted therapies, with the aim of improving the prognosis and quality of life of patients affected by cholestatic liver diseases.
publishDate	2026
dc.date.none.fl_str_mv	2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29432
url	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=29432
dc.language.none.fl_str_mv	Español
language_invalid_str_mv	Español
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER ESPANA SLU
publisher.none.fl_str_mv	ELSEVIER ESPANA SLU
dc.source.none.fl_str_mv	Gastroenterologia y Hepatologia ISSN: 02105705 reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname:Fundació Sant Joan de Déu
instname_str	Fundació Sant Joan de Déu
reponame_str	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.811543

Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP.

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