Substrate stiffness and pressure alter retinal Müller glia response and extracellular matrix production

[Background] The retina is highly influenced by its mechanical environment, with Müller glia (MG) acting as key mechanosensors and extracellular matrix (ECM) producers. This study examined MG responses to substrate stiffness and high pressure (HP), and whether TGF-β1 modulation could mitigate these...

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Detalhes bibliográficos
Autores: Prieto López, Laura, Pereiro, Xandra, Ramírez, Emilio J. González, Ruzafa, Noelia, Alonso, Alicia, Franze, Kristian, Vecino, Elena
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/399111
Acesso em linha:http://hdl.handle.net/10261/399111
https://api.elsevier.com/content/abstract/scopus_id/105010072979
Access Level:acceso abierto
Palavra-chave:Extracellular matrix
Müller glia
Polyacrylamide gels
Pressure
Stiffness
TGF-β1
Descrição
Resumo:[Background] The retina is highly influenced by its mechanical environment, with Müller glia (MG) acting as key mechanosensors and extracellular matrix (ECM) producers. This study examined MG responses to substrate stiffness and high pressure (HP), and whether TGF-β1 modulation could mitigate these effects.

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