Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses
BACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian ra...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/173314 |
| Acceso en línea: | https://hdl.handle.net/2445/173314 |
| Access Level: | acceso abierto |
| Palabra clave: | Càncer colorectal Insulina Colorectal cancer Insulin |
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oai:recercat.cat:2445/173314 |
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España |
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| dc.title.none.fl_str_mv |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| title |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| spellingShingle |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses Murphy, Neil Càncer colorectal Insulina Colorectal cancer Insulin |
| title_short |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| title_full |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| title_fullStr |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| title_full_unstemmed |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| title_sort |
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses |
| dc.creator.none.fl_str_mv |
Murphy, Neil Carreras Torres, Robert Song, Mingyang Chan, Andrew T. Martin, Richard M. Papadimitriou, Nikos Dimou, Niki Tsilidis, Konstantinos K. Banbury, Barbara L. Bradbury, Kathryn E. Besevic, Jelena Rinaldi, Sabina Riboli, Elio Cross, Amanda J. Travis, Ruth C. Agnoli, Claudia Albanes, Demetrius Berndt, Sonja I. Bézieau, Stéphane Bishop, D. Timothy Brenner, Hermann Buchanan, Daniel D. Onland-Moret, N. Charlotte Burnett-Hartman, Andrea Campbell, Peter T. Casey, Graham Castellví Bel, Sergi Chang-Claude, Jenny Chirlaque, María Dolores Chapelle, Albert de la English, Dallas R. Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Hampe, Jochen Hampel, Heather Harrison, Tabitha A. Hoffmeister, Michael Hsu, Li Huang, Wen-Yi Huyghe, Jeroen R. Jenkins, Mark A. Keku, Temitope O. Kühn, Tilman Kweon, Sun-Seog Marchand, Loïc Le Li, Christopher I. Li, Li Lindblom, Annika Martín Sánchez, Vicente Milne, Roger L. Moreno Aguado, Víctor Newcomb, Polly A. Offit, Kenneth Ogino, Shuji Ose, Jennifer Perduca, Vittorio Phipps, Amanda I. Platz, Elizabeth A. Potter, John D. Qu, Conghui Rennert, Gad Sakoda, Lori C. Schafmayer, Clemens Schoen, Robert E. Slattery, Martha L. Tangen, Catherine M. Ulrich, Cornelia M. van Duijnhoven, Franzel J. B. Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Vodickova, Ludmila Vymetalkova, Veronika Wang, Hansong White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zheng, Wei Peters, Ulrike Gunter, Marc J. |
| author |
Murphy, Neil |
| author_facet |
Murphy, Neil Carreras Torres, Robert Song, Mingyang Chan, Andrew T. Martin, Richard M. Papadimitriou, Nikos Dimou, Niki Tsilidis, Konstantinos K. Banbury, Barbara L. Bradbury, Kathryn E. Besevic, Jelena Rinaldi, Sabina Riboli, Elio Cross, Amanda J. Travis, Ruth C. Agnoli, Claudia Albanes, Demetrius Berndt, Sonja I. Bézieau, Stéphane Bishop, D. Timothy Brenner, Hermann Buchanan, Daniel D. Onland-Moret, N. Charlotte Burnett-Hartman, Andrea Campbell, Peter T. Casey, Graham Castellví Bel, Sergi Chang-Claude, Jenny Chirlaque, María Dolores Chapelle, Albert de la English, Dallas R. Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Hampe, Jochen Hampel, Heather Harrison, Tabitha A. Hoffmeister, Michael Hsu, Li Huang, Wen-Yi Huyghe, Jeroen R. Jenkins, Mark A. Keku, Temitope O. Kühn, Tilman Kweon, Sun-Seog Marchand, Loïc Le Li, Christopher I. Li, Li Lindblom, Annika Martín Sánchez, Vicente Milne, Roger L. Moreno Aguado, Víctor Newcomb, Polly A. Offit, Kenneth Ogino, Shuji Ose, Jennifer Perduca, Vittorio Phipps, Amanda I. Platz, Elizabeth A. Potter, John D. Qu, Conghui Rennert, Gad Sakoda, Lori C. Schafmayer, Clemens Schoen, Robert E. Slattery, Martha L. Tangen, Catherine M. Ulrich, Cornelia M. van Duijnhoven, Franzel J. B. Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Vodickova, Ludmila Vymetalkova, Veronika Wang, Hansong White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zheng, Wei Peters, Ulrike Gunter, Marc J. |
| author_role |
author |
| author2 |
Carreras Torres, Robert Song, Mingyang Chan, Andrew T. Martin, Richard M. Papadimitriou, Nikos Dimou, Niki Tsilidis, Konstantinos K. Banbury, Barbara L. Bradbury, Kathryn E. Besevic, Jelena Rinaldi, Sabina Riboli, Elio Cross, Amanda J. Travis, Ruth C. Agnoli, Claudia Albanes, Demetrius Berndt, Sonja I. Bézieau, Stéphane Bishop, D. Timothy Brenner, Hermann Buchanan, Daniel D. Onland-Moret, N. Charlotte Burnett-Hartman, Andrea Campbell, Peter T. Casey, Graham Castellví Bel, Sergi Chang-Claude, Jenny Chirlaque, María Dolores Chapelle, Albert de la English, Dallas R. Figueiredo, Jane C. Gallinger, Steven Giles, Graham G. Gruber, Stephen B. Gsur, Andrea Hampe, Jochen Hampel, Heather Harrison, Tabitha A. Hoffmeister, Michael Hsu, Li Huang, Wen-Yi Huyghe, Jeroen R. Jenkins, Mark A. Keku, Temitope O. Kühn, Tilman Kweon, Sun-Seog Marchand, Loïc Le Li, Christopher I. Li, Li Lindblom, Annika Martín Sánchez, Vicente Milne, Roger L. Moreno Aguado, Víctor Newcomb, Polly A. Offit, Kenneth Ogino, Shuji Ose, Jennifer Perduca, Vittorio Phipps, Amanda I. Platz, Elizabeth A. Potter, John D. Qu, Conghui Rennert, Gad Sakoda, Lori C. Schafmayer, Clemens Schoen, Robert E. Slattery, Martha L. Tangen, Catherine M. Ulrich, Cornelia M. van Duijnhoven, Franzel J. B. Van Guelpen, Bethany Visvanathan, Kala Vodicka, Pavel Vodickova, Ludmila Vymetalkova, Veronika Wang, Hansong White, Emily Wolk, Alicja Woods, Michael O. Wu, Anna H. Zheng, Wei Peters, Ulrike Gunter, Marc J. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Càncer colorectal Insulina Colorectal cancer Insulin |
| topic |
Càncer colorectal Insulina Colorectal cancer Insulin |
| description |
BACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development. METHODS: Serum levels of IGF1 and other proteins were measured in blood samples collected from 397,380 participants from the UK Biobank, from 2006 through 2010. Incident cancer cases and cancer cases recorded first in death certificates were identified through linkage to national cancer and death registries. Complete follow-up was available through March 31, 2016. For the MR analyses, we identified genetic variants associated with circulating levels of IGF1 and IGFBP3. The association of these genetic variants with colorectal cancer was examined with 2-sample MR methods using genome-wide association study consortia data (52,865 cases with colorectal cancer and 46,287 individuals without [controls]) RESULTS: After a median follow-up period of 7.1 years, 2665 cases of colorectal cancer were recorded. In a multivariable-adjusted model, circulating level of IGF1 level associated with colorectal cancer risk (hazard ratio per 1 standard deviation increment of IGF1, 1.11; 95% confidence interval [CI] 1.05-1.17). Similar associations were found by sex, follow-up time, and tumor subsite. In the MR analyses, a 1 standard deviation increment in IGF1 level, predicted based on genetic factors, was associated with a higher risk of colorectal cancer risk (odds ratio 1.08; 95% CI 1.03-1.12; P = 3.3 × 10-4). Level of IGFBP3, predicted based on genetic factors, was associated with colorectal cancer risk (odds ratio per 1 standard deviation increment, 1.12; 95% CI 1.06-1.18; P = 4.2 × 10-5). Colorectal cancer risk was associated with only 1 variant in IGFBP3 (rs11977526), which also associated with anthropometric traits and circulating level of IGF2. CONCLUSIONS: In an analysis of blood samples from almost 400,000 participants in the UK Biobank, we found an association between circulating level of IGF1 and colorectal cancer. Using genetic data from 52,865 cases with colorectal cancer and 46,287 controls, a higher level of IGF1, determined by genetic factors, was associated with colorectal cancer. Further studies are needed to determine how this signaling pathway might contribute to colorectal carcinogenesis. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/173314 |
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https://hdl.handle.net/2445/173314 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1053/j.gastro.2019.12.020 Gastroenterology, 2019, vol. S0016-5085, num. 19, p. 41951-41953 https://doi.org/10.1053/j.gastro.2019.12.020 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd (c) AGA Institute, 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess |
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cc-by-nc-nd (c) AGA Institute, 2020 http://creativecommons.org/licenses/by-nc-nd/3.0/es |
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openAccess |
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3 p. application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869414722537783296 |
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Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization AnalysesMurphy, NeilCarreras Torres, RobertSong, MingyangChan, Andrew T.Martin, Richard M.Papadimitriou, NikosDimou, NikiTsilidis, Konstantinos K.Banbury, Barbara L.Bradbury, Kathryn E.Besevic, JelenaRinaldi, SabinaRiboli, ElioCross, Amanda J.Travis, Ruth C.Agnoli, ClaudiaAlbanes, DemetriusBerndt, Sonja I.Bézieau, StéphaneBishop, D. TimothyBrenner, HermannBuchanan, Daniel D.Onland-Moret, N. CharlotteBurnett-Hartman, AndreaCampbell, Peter T.Casey, GrahamCastellví Bel, SergiChang-Claude, JennyChirlaque, María DoloresChapelle, Albert de laEnglish, Dallas R.Figueiredo, Jane C.Gallinger, StevenGiles, Graham G.Gruber, Stephen B.Gsur, AndreaHampe, JochenHampel, HeatherHarrison, Tabitha A.Hoffmeister, MichaelHsu, LiHuang, Wen-YiHuyghe, Jeroen R.Jenkins, Mark A.Keku, Temitope O.Kühn, TilmanKweon, Sun-SeogMarchand, Loïc LeLi, Christopher I.Li, LiLindblom, AnnikaMartín Sánchez, VicenteMilne, Roger L.Moreno Aguado, VíctorNewcomb, Polly A.Offit, KennethOgino, ShujiOse, JenniferPerduca, VittorioPhipps, Amanda I.Platz, Elizabeth A.Potter, John D.Qu, ConghuiRennert, GadSakoda, Lori C.Schafmayer, ClemensSchoen, Robert E.Slattery, Martha L.Tangen, Catherine M.Ulrich, Cornelia M.van Duijnhoven, Franzel J. B.Van Guelpen, BethanyVisvanathan, KalaVodicka, PavelVodickova, LudmilaVymetalkova, VeronikaWang, HansongWhite, EmilyWolk, AlicjaWoods, Michael O.Wu, Anna H.Zheng, WeiPeters, UlrikeGunter, Marc J.Càncer colorectalInsulinaColorectal cancerInsulinBACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development. METHODS: Serum levels of IGF1 and other proteins were measured in blood samples collected from 397,380 participants from the UK Biobank, from 2006 through 2010. Incident cancer cases and cancer cases recorded first in death certificates were identified through linkage to national cancer and death registries. Complete follow-up was available through March 31, 2016. For the MR analyses, we identified genetic variants associated with circulating levels of IGF1 and IGFBP3. The association of these genetic variants with colorectal cancer was examined with 2-sample MR methods using genome-wide association study consortia data (52,865 cases with colorectal cancer and 46,287 individuals without [controls]) RESULTS: After a median follow-up period of 7.1 years, 2665 cases of colorectal cancer were recorded. In a multivariable-adjusted model, circulating level of IGF1 level associated with colorectal cancer risk (hazard ratio per 1 standard deviation increment of IGF1, 1.11; 95% confidence interval [CI] 1.05-1.17). Similar associations were found by sex, follow-up time, and tumor subsite. In the MR analyses, a 1 standard deviation increment in IGF1 level, predicted based on genetic factors, was associated with a higher risk of colorectal cancer risk (odds ratio 1.08; 95% CI 1.03-1.12; P = 3.3 × 10-4). Level of IGFBP3, predicted based on genetic factors, was associated with colorectal cancer risk (odds ratio per 1 standard deviation increment, 1.12; 95% CI 1.06-1.18; P = 4.2 × 10-5). Colorectal cancer risk was associated with only 1 variant in IGFBP3 (rs11977526), which also associated with anthropometric traits and circulating level of IGF2. CONCLUSIONS: In an analysis of blood samples from almost 400,000 participants in the UK Biobank, we found an association between circulating level of IGF1 and colorectal cancer. Using genetic data from 52,865 cases with colorectal cancer and 46,287 controls, a higher level of IGF1, determined by genetic factors, was associated with colorectal cancer. Further studies are needed to determine how this signaling pathway might contribute to colorectal carcinogenesis.Elsevier2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion3 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/173314Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1053/j.gastro.2019.12.020Gastroenterology, 2019, vol. S0016-5085, num. 19, p. 41951-41953https://doi.org/10.1053/j.gastro.2019.12.020cc-by-nc-nd (c) AGA Institute, 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1733142026-05-29T05:05:01Z |
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