HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity

This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compar...

Descripción completa

Detalles Bibliográficos
Autores: Pernas, Maria, Sanchez-Merino, Victor, Casado, Concepcion, Merino-Mansilla, Alberto, Olivares, Isabel, Yuste-Herranz, Maria Eloisa, Lopez-Galindez, Luis Cecilio
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6929
Acceso en línea:http://hdl.handle.net/20.500.12105/6929
Access Level:acceso abierto
Palabra clave:Antibodies, Neutralizing
Entropy
Follow-Up Studies
Genetic Variation
HIV Antibodies
HIV Infections
HIV-1
Humans
Neutralization Tests
Phylogeny
Viral Load
Viremia
HIV Long-Term Survivors
id ES_9d070ee528608aeefcab0d1ff37fd849
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/6929
network_acronym_str ES
network_name_str España
repository_id_str
spelling HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing ActivityPernas, MariaSanchez-Merino, VictorCasado, ConcepcionMerino-Mansilla, AlbertoOlivares, IsabelYuste-Herranz, Maria EloisaLopez-Galindez, Luis CecilioAntibodies, NeutralizingEntropyFollow-Up StudiesGenetic VariationHIV AntibodiesHIV InfectionsHIV-1HumansNeutralization TestsPhylogenyViral LoadViremiaHIV Long-Term SurvivorsThis study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.Public Library of Science (PLOS)Fundación para la Investigación y la Prevención del Sida en EspañaRed de Investigación Cooperativa en Investigación en Sida (España)Instituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Ministerio de Ciencia y Tecnología (España)20182018-12-2120152015-08-1020152015-08-10journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6929reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI 13 02269ES RD12 0017ES RYC-2007-00788 Not availableES PS09 01459open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/69292026-06-12T12:43:37Z
dc.title.none.fl_str_mv HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
title HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
spellingShingle HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
Pernas, Maria
Antibodies, Neutralizing
Entropy
Follow-Up Studies
Genetic Variation
HIV Antibodies
HIV Infections
HIV-1
Humans
Neutralization Tests
Phylogeny
Viral Load
Viremia
HIV Long-Term Survivors
title_short HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
title_full HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
title_fullStr HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
title_full_unstemmed HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
title_sort HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
dc.creator.none.fl_str_mv Pernas, Maria
Sanchez-Merino, Victor
Casado, Concepcion
Merino-Mansilla, Alberto
Olivares, Isabel
Yuste-Herranz, Maria Eloisa
Lopez-Galindez, Luis Cecilio
author Pernas, Maria
author_facet Pernas, Maria
Sanchez-Merino, Victor
Casado, Concepcion
Merino-Mansilla, Alberto
Olivares, Isabel
Yuste-Herranz, Maria Eloisa
Lopez-Galindez, Luis Cecilio
author_role author
author2 Sanchez-Merino, Victor
Casado, Concepcion
Merino-Mansilla, Alberto
Olivares, Isabel
Yuste-Herranz, Maria Eloisa
Lopez-Galindez, Luis Cecilio
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación para la Investigación y la Prevención del Sida en España
Red de Investigación Cooperativa en Investigación en Sida (España)
Instituto de Salud Carlos III
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Ministerio de Ciencia y Tecnología (España)
dc.subject.none.fl_str_mv Antibodies, Neutralizing
Entropy
Follow-Up Studies
Genetic Variation
HIV Antibodies
HIV Infections
HIV-1
Humans
Neutralization Tests
Phylogeny
Viral Load
Viremia
HIV Long-Term Survivors
topic Antibodies, Neutralizing
Entropy
Follow-Up Studies
Genetic Variation
HIV Antibodies
HIV Infections
HIV-1
Humans
Neutralization Tests
Phylogeny
Viral Load
Viremia
HIV Long-Term Survivors
description This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-08-10
2015
2015-08-10
2018
2018-12-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6929
url http://hdl.handle.net/20.500.12105/6929
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PI 13 02269
ES RD12 0017
ES RYC-2007-00788 Not available
ES PS09 01459
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414708452261888
score 15,81155

Similares en LA Referencia