HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity

This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compar...

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Bibliographic Details
Authors: Pernas, Maria, Sanchez-Merino, Victor, Casado, Concepcion, Merino-Mansilla, Alberto, Olivares, Isabel, Yuste-Herranz, Maria Eloisa, Lopez-Galindez, Luis Cecilio
Format: article
Publication Date:2015
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6929
Online Access:http://hdl.handle.net/20.500.12105/6929
Access Level:Open access
Keyword:Antibodies, Neutralizing
Entropy
Follow-Up Studies
Genetic Variation
HIV Antibodies
HIV Infections
HIV-1
Humans
Neutralization Tests
Phylogeny
Viral Load
Viremia
HIV Long-Term Survivors
Description
Summary:This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.

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