Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety

The rise and development of nanotechnology has permitted to create of a wide number of systems able to accomplish new and advantageous features to treat cancer. However in many cases, the lone application of those new nanotherapeutics has proven not to be enough to achieve acceptable therapeutic eff...

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Detalles Bibliográficos
Autores: Castillo, Rafael R., Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/13122
Acceso en línea:https://hdl.handle.net/20.500.14352/13122
Access Level:acceso abierto
Palabra clave:615.46
546
Mesoporous Silica
Magnetic
Photothermal
Photodynamic
Combination therapy
Drug Delivery
Química inorgánica (Farmacia)
Tecnología farmaceútica
Descripción
Sumario:The rise and development of nanotechnology has permitted to create of a wide number of systems able to accomplish new and advantageous features to treat cancer. However in many cases, the lone application of those new nanotherapeutics has proven not to be enough to achieve acceptable therapeutic efficacies. Hence, to avoid these limitations, the scientific community has been embarked on the development of single formulations capable of combining functionalities. Among all possible components, silica –either solid or mesoporous–, has become of importance as connecting and coating material for those new-generation therapeutic nanodevices. In the present review there are visited the most recent examples of fully-inorganic silica-based functional composites, paying especial attention to those with potential biomedical applicability. Additionally, there will be given some highlights about their possible biosafety issues based on their chemical composition.