Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids...

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Detalles Bibliográficos
Autores: Marhuenda-Muñoz, María, Domínguez López, Inés, Langohr, Klaus, Tresserra i Rimbau, Anna, Martínez-González, Miguel Ángel, 1957-, Salas Salvadó, Jordi, Corella Piquer, Dolores, Zomeño Fajardo, María Dolores, Martínez, J. Alfredo, 1957-, Alonso Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López Miranda, José, Estruch Riba, Ramon, Tinahones, Francisco J., Lapetra, José, Serra Majem, Lluís, Bueno Cavanillas, Aurora, Tur, Josep Antoni, Martín Sánchez, Vicente, Pintó Sala, Xavier, Delgado Rodriguez, Miguel, Matía Martín, Pilar, Vidal i Cortada, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros Rahola, Emilio, Toledo Atucha, Estefanía, Fernández de la Puente, María, Barragán, Rocío, Fitó Colomer, Montserrat, Tojal Sierra, Lucas, Gómez Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, García Ríos, Antonio, Casas Rodríguez, Rosa M., Gómez Pérez, Ana María, Santos Lozano, José Manuel, Vázquez Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M., Gili Riu, M Mar, Bullón Vela, Vanessa, Moreno Rodriguez, Anai, Lecea Juárez, Oscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, Lamuela Raventós, Rosa Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/190410
Acceso en línea:https://hdl.handle.net/2445/190410
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Carotenoides
Plasma sanguini
Cromatografia de líquids
Espectrometria de masses
Cuina mediterrània
Cardiovascular diseases
Carotenoids
Blood plasma
Liquid chromatography
Mass spectrometry
Mediterranean cooking
Descripción
Sumario:Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001]. Keywords: Mediterranean diet; PREDIMED-plus study; cardiovascular health; liquid chromatography; mass spectrometry; plasma carotenoids.

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