Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids...

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Autores: Marhuenda-Muñoz, María, Domínguez-López, Inés, Langohr, Klaus, Tresserra-Rimbau, Anna, Martínez González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Zomeño Fajardo, Maria Dolores, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Fernández de la Puente Cervera, María, Barragán, Rocío, Fitó, Montserrat, Tojal-Sierra, Lucas, Gómez-Gracia, Enrique, Zazo, Juan Manuel, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Gómez-Pérez, Ana María, Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Atzeni, Alessandro, Asensio, Eva M., Gili-Riu, M. Mar, Bullon, Vanessa, Moreno-Rodríguez, Anai, Lecea, Óscar, Babio, Nancy, Peñas Lopez, Francesca, Gómez Melis, Guadalupe, Lamuela-Raventós, Rosa M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/295318
Acceso en línea:http://hdl.handle.net/10261/295318
Access Level:acceso abierto
Palabra clave:Mediterranean diet
PREDIMED-plus study
Plasma carotenoids
Cardiovascular health
Liquid chromatography
Mass spectrometry
Descripción
Sumario:Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [−2.79 mg/dl (95% CI: −4.25, −1.34) and −5.15 mg/dl (95% CI: −7.38, −2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [−0.09% (95% CI: −0.14, −0.03) and −0.15 % (95% CI: −0.23, −0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: −0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [−1.35 mg/dl (95% CI: −2.12, −0.59), p-value: 0.001].

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