Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?

Introduction: Kawasaki disease (KD) is a multisystem vasculitis associated with coronary artery abnormalities. Infections could be a trigger of the inflammation. The main aim of this study was to describe the presence of infections in children with KD, and to analyse the clinical characteristics and...

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Autores: Fernández-Cooke E, Barrios Tascón A, Antón-López J, Grasa Lozano CD, Sánchez-Manubens J, Calvo C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p14739
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14739
Access Level:acceso abierto
Palabra clave:Kawasaki disease
Vasculitis
Coronary aneurysm
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spelling Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?Fernández-Cooke EBarrios Tascón AAntón-López JGrasa Lozano CDSánchez-Manubens JCalvo CKawasaki diseaseVasculitisCoronary aneurysmIntroduction: Kawasaki disease (KD) is a multisystem vasculitis associated with coronary artery abnormalities. Infections could be a trigger of the inflammation. The main aim of this study was to describe the presence of infections in children with KD, and to analyse the clinical characteristics and the presence of coronary abnormalities in these cases. Patients and methods: A retrospective study was performed within the Kawasaki Diseases Network (KAWA-RACE (2011-2016). An analysis was performed that included patients with positive microbiological findings (PMF) during the acute phase, as well as those with a previous recent infection (PRI) during the 4 weeks preceding KD diagnosis. Results: The study included total of 621 children with KD, with PMF being found in 101 (16.3%) patients, and a PRI in 107 (17.2%). Significantly less echocardiographic abnormalities were found in the in the group with a PRI, when compared to those without a PRI (23 vs. 35%, P=.01) and also a lower proportion of overall coronary artery lesions (16 vs. 25%, P=.054). No significant differences were found in the proportion of aneurysms in either of these groups (PRI or PMF) when compared to those without infection. Conclusions: In the present study, no differences were found in the incidence of coronary aneurysms in either of the groups, with or without PRI or PMF. Therefore, if KD is suspected, appropriate treatment should be started despite having a confirmed infection. (c) 2018 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.EDICIONES DOYMA S A2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14739ANALES DE PEDIATRIAISSN: 16954033ISSNe: 16959531reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuEspañolinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p147392026-05-27T12:37:41Z
dc.title.none.fl_str_mv Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
title Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
spellingShingle Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
Fernández-Cooke E
Kawasaki disease
Vasculitis
Coronary aneurysm
title_short Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
title_full Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
title_fullStr Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
title_full_unstemmed Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
title_sort Previous or coincident infections with suspected Kawasaki disease. Should we change our approach?
dc.creator.none.fl_str_mv Fernández-Cooke E
Barrios Tascón A
Antón-López J
Grasa Lozano CD
Sánchez-Manubens J
Calvo C
author Fernández-Cooke E
author_facet Fernández-Cooke E
Barrios Tascón A
Antón-López J
Grasa Lozano CD
Sánchez-Manubens J
Calvo C
author_role author
author2 Barrios Tascón A
Antón-López J
Grasa Lozano CD
Sánchez-Manubens J
Calvo C
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Kawasaki disease
Vasculitis
Coronary aneurysm
topic Kawasaki disease
Vasculitis
Coronary aneurysm
description Introduction: Kawasaki disease (KD) is a multisystem vasculitis associated with coronary artery abnormalities. Infections could be a trigger of the inflammation. The main aim of this study was to describe the presence of infections in children with KD, and to analyse the clinical characteristics and the presence of coronary abnormalities in these cases. Patients and methods: A retrospective study was performed within the Kawasaki Diseases Network (KAWA-RACE (2011-2016). An analysis was performed that included patients with positive microbiological findings (PMF) during the acute phase, as well as those with a previous recent infection (PRI) during the 4 weeks preceding KD diagnosis. Results: The study included total of 621 children with KD, with PMF being found in 101 (16.3%) patients, and a PRI in 107 (17.2%). Significantly less echocardiographic abnormalities were found in the in the group with a PRI, when compared to those without a PRI (23 vs. 35%, P=.01) and also a lower proportion of overall coronary artery lesions (16 vs. 25%, P=.054). No significant differences were found in the proportion of aneurysms in either of these groups (PRI or PMF) when compared to those without infection. Conclusions: In the present study, no differences were found in the incidence of coronary aneurysms in either of the groups, with or without PRI or PMF. Therefore, if KD is suspected, appropriate treatment should be started despite having a confirmed infection. (c) 2018 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14739
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14739
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv EDICIONES DOYMA S A
publisher.none.fl_str_mv EDICIONES DOYMA S A
dc.source.none.fl_str_mv ANALES DE PEDIATRIA
ISSN: 16954033
ISSNe: 16959531
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
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collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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