Palmitoylcarnitine impairs immunity in decompensated cirrhosis

Wei Zhang, Ingrid; Sánchez-Rodríguez, María Belén; López-Vicario, Cristina; Casulleras, Mireia; Duran-Güell, Marta; Flores-Costa, Roger; Aguilar, Ferran; Rothe, Michael; Segalés, Paula; García-Ruiz, Carmen; Fernández-Checa, José C.; Trebicka, Jonel; Arroyo, Vicente; Clària, Joan

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

In patients with cirrhosis, acute decompensation (AD) correlates with a hyperinflammatory state driven by mitochondrial dysfunction, which is a significant factor in the progression toward acute-on-chronic liver failure (ACLF). Elevated circulating levels of acylcarnitine, indicative of mitochondria...

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Detalles Bibliográficos
Autores:	Wei Zhang, Ingrid, Sánchez-Rodríguez, María Belén, López-Vicario, Cristina, Casulleras, Mireia, Duran-Güell, Marta, Flores-Costa, Roger, Aguilar, Ferran, Rothe, Michael, Segalés, Paula, García-Ruiz, Carmen, Fernández-Checa, José C., Trebicka, Jonel, Arroyo, Vicente, Clària, Joan
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2024
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/374201
Acceso en línea:	http://hdl.handle.net/10261/374201 https://api.elsevier.com/content/abstract/scopus_id/85207272236
Access Level:	acceso abierto
Palabra clave:	Acute decompensation of cirrhosis Acylcarnitines Immune cells Mitochondrial dysfunction

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dc.title.none.fl_str_mv	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
title	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
spellingShingle	Palmitoylcarnitine impairs immunity in decompensated cirrhosis Wei Zhang, Ingrid Acute decompensation of cirrhosis Acylcarnitines Immune cells Mitochondrial dysfunction
title_short	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
title_full	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
title_fullStr	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
title_full_unstemmed	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
title_sort	Palmitoylcarnitine impairs immunity in decompensated cirrhosis
dc.creator.none.fl_str_mv	Wei Zhang, Ingrid Sánchez-Rodríguez, María Belén López-Vicario, Cristina Casulleras, Mireia Duran-Güell, Marta Flores-Costa, Roger Aguilar, Ferran Rothe, Michael Segalés, Paula García-Ruiz, Carmen Fernández-Checa, José C. Trebicka, Jonel Arroyo, Vicente Clària, Joan
author	Wei Zhang, Ingrid
author_facet	Wei Zhang, Ingrid Sánchez-Rodríguez, María Belén López-Vicario, Cristina Casulleras, Mireia Duran-Güell, Marta Flores-Costa, Roger Aguilar, Ferran Rothe, Michael Segalés, Paula García-Ruiz, Carmen Fernández-Checa, José C. Trebicka, Jonel Arroyo, Vicente Clària, Joan
author_role	author
author2	Sánchez-Rodríguez, María Belén López-Vicario, Cristina Casulleras, Mireia Duran-Güell, Marta Flores-Costa, Roger Aguilar, Ferran Rothe, Michael Segalés, Paula García-Ruiz, Carmen Fernández-Checa, José C. Trebicka, Jonel Arroyo, Vicente Clària, Joan
author2_role	author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Ministerio de Ciencia e Innovación (España) Generalitat de Catalunya European Commission Fundació La Marató de TV3 National Institute on Alcohol Abuse and Alcoholism (US) National Institutes of Health (US) German Research Foundation Federal Ministry of Education and Research (Germany) Hessen State Ministry of Higher Education, Research and the Arts European Association for the Study of the Liver García-Ruiz, Carmen [0000-0002-2652-6102] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Acute decompensation of cirrhosis Acylcarnitines Immune cells Mitochondrial dysfunction
topic	Acute decompensation of cirrhosis Acylcarnitines Immune cells Mitochondrial dysfunction
description	In patients with cirrhosis, acute decompensation (AD) correlates with a hyperinflammatory state driven by mitochondrial dysfunction, which is a significant factor in the progression toward acute-on-chronic liver failure (ACLF). Elevated circulating levels of acylcarnitine, indicative of mitochondrial dysfunction, are predictors of mortality in ACLF patients. Our hypothesis posits that acylcarnitines not only act as biomarkers, but also actively exert detrimental effects on circulating immune cells.
publishDate	2024
dc.date.none.fl_str_mv	2024 2024 2024
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format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/374201 https://api.elsevier.com/content/abstract/scopus_id/85207272236
url	http://hdl.handle.net/10261/374201 https://api.elsevier.com/content/abstract/scopus_id/85207272236
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
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dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
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spelling	Palmitoylcarnitine impairs immunity in decompensated cirrhosisWei Zhang, IngridSánchez-Rodríguez, María BelénLópez-Vicario, CristinaCasulleras, MireiaDuran-Güell, MartaFlores-Costa, RogerAguilar, FerranRothe, MichaelSegalés, PaulaGarcía-Ruiz, CarmenFernández-Checa, José C.Trebicka, JonelArroyo, VicenteClària, JoanAcute decompensation of cirrhosisAcylcarnitinesImmune cellsMitochondrial dysfunctionIn patients with cirrhosis, acute decompensation (AD) correlates with a hyperinflammatory state driven by mitochondrial dysfunction, which is a significant factor in the progression toward acute-on-chronic liver failure (ACLF). Elevated circulating levels of acylcarnitine, indicative of mitochondrial dysfunction, are predictors of mortality in ACLF patients. Our hypothesis posits that acylcarnitines not only act as biomarkers, but also actively exert detrimental effects on circulating immune cells.Supported by the Plan Nacional de I+D funded by the Agencia Estatal de Investigación (grants PID2019-105240RB-I00 and PID2022-138970OB-I00 [to JC] and PID2019-111669RB-100 and PID2020-115055RB-I00 [to JCF-C]). JC laboratory is a Consolidated Research Group recognised by the Generalitat de Catalunya (2021 SGR 01323) and receives funds from EF CLIF and European Union’s Horizon 2020 research and innovation programme (MICROB-PREDICT [project ID 825694], DECISION [project ID 847949]). JCF-C receives funds from the center grant P50AA011999 Southern California Research Center for ALPD and Cirrhosis funded by NIAAA/NIH, the Project 201916/31 by Fundació Marató TV3 and the European Horizon´s research and innovation program HORIZON-HLTH-2022-STAYHLTH-02 under agreement No 101095679. JT is supported by the German Research Foundation project ID 403224013 – SFB 1382 (A09), by the German Federal Ministry of Education and Research for the DEEP-HCC project and by the Hessian Ministry of Higher Education, Research, the Arts for the ENABLE and ACLF-I cluster projects and the European Union’s Horizon 2020 research and innovation program for MICROB-PREDICT (project ID 825694), DECISION (project ID 847949), GALAXY (project ID 668031), LIVERHOPE (project ID 731875), and IHMCSA (project ID 964590) projects. IWZ was supported by the Sheila Sherlock Post Graduate Programme of the European Association for the Study of the Liver.Peer reviewedElsevierAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Ministerio de Ciencia e Innovación (España)Generalitat de CatalunyaEuropean CommissionFundació La Marató de TV3National Institute on Alcohol Abuse and Alcoholism (US)National Institutes of Health (US)German Research FoundationFederal Ministry of Education and Research (Germany)Hessen State Ministry of Higher Education, Research and the ArtsEuropean Association for the Study of the LiverGarcía-Ruiz, Carmen [0000-0002-2652-6102]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/374201https://api.elsevier.com/content/abstract/scopus_id/85207272236reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105240RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-138970OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111669RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-115055RB-I00info:eu-repo/grantAgreement/EC/H2020/825694info:eu-repo/grantAgreement/EC/H2020/847949info:eu-repo/grantAgreement/EC/HE/101095679info:eu-repo/grantAgreement/EC/H2020/668031info:eu-repo/grantAgreement/EC/H2020/731875info:eu-repo/grantAgreement/EC/H2020/964590Wei Zhang, Ingrid; Sánchez-Rodríguez, María Belén; López-Vicario, Cristina; Casulleras, Mireia; Duran-Güell, Marta; Flores-Costa, Roger; Aguilar, Ferran; Rothe, Michael; Segalés, Paula; García-Ruiz, Carmen ; Fernández-Checa, José C.; Trebicka, Jonel; Arroyo, Vicente; Clària, Joan; 2024; Supplementary data Palmitoylcarnitine impairs immunity in decompensated cirrhosis [Dataset]; Elsevier; https://doi.org/10.1016/j.jhepr.2024.101187https://doi.org/10.1016/j.jhepr.2024.101187Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3742012026-05-22T06:33:51Z
score	15,81155

Palmitoylcarnitine impairs immunity in decompensated cirrhosis

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