Micronutrient Deficiencies in Patients with Decompensated Liver Cirrhosis

Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our main goal was to assess the prevalence of micronutrient deficiencies in patients with decompensated cirrhosis. This was a prospective single-center study inclu...

Descripción completa

Detalles Bibliográficos
Autores: Llibre-Nieto, Gemma|||0000-0002-5132-7623, Lira, Alba|||0000-0001-9280-613X, Vergara, Mercedes|||0000-0002-6971-8657, Solé Martí, Cristina|||0000-0002-6104-8345, Casas, Meritxell|||0000-0001-7227-7277, Puig Diví, Valentí|||0000-0001-5756-2686, Solé, Gemma, Humanes, Antonia, Grau-López, Laia|||0000-0002-5272-0806, Barradas, Josep Maria, Miquel Planas, Mireia|||0000-0003-4566-4962, Sánchez Delgado, Jordi|||0000-0002-5217-6492
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:255510
Acceso en línea:https://ddd.uab.cat/record/255510
https://dx.doi.org/urn:doi:10.3390/nu13041249
Access Level:acceso abierto
Palabra clave:Micronutrient deficiency
Trace element deficiency
Vitamin deficiency
Malnutrition
Decompensated cirrhosis
Descripción
Sumario:Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our main goal was to assess the prevalence of micronutrient deficiencies in patients with decompensated cirrhosis. This was a prospective single-center study including 125 consecutive patients hospitalized for acute decompensation of cirrhosis (mostly of alcoholic etiology). A blood test including trace elements and vitamins was performed on admission. The main micronutrient deficiencies observed were vitamin D (in 94.5%), vitamin A (93.5%), vitamin B6 (60.8%) and zinc (85.6%). Patients in Child-Pugh class C had lower levels of vitamin A (p < 0.0001), vitamin E (p = 0.01) and zinc (p < 0.001), and higher levels of ferritin (p = 0.002) and vitamin B12 (p < 0.001) than those in Child-Pugh class A and B. Patients with a higher model of end-stage liver disease (MELD) score had lower levels of vitamin A (p < 0.0001), vitamin E (p < 0.001), magnesium (p = 0.01) and zinc (p = 0.001), and higher levels of ferritin (p = 0.002) and vitamin B12 (p < 0.0001). Severe hepatic insufficiency correlated with lower levels of zinc, vitamin E and vitamin A, and higher levels of vitamin B12 and ferritin.

Similares en LA Referencia