The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae

12 páginas, 7 figuras, 3 tablas.-- El pdf del artículo es la versión de autor.

Detalles Bibliográficos
Autores: Jiménez-Martín, Alberto, Lisa-Santamaría, Patricia, García-Marino, Matilde, Rivas-Gonzalo, Julián C., Revuelta Doval, José Luis
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/49622
Acceso en línea:http://hdl.handle.net/10261/49622
Access Level:acceso abierto
Palabra clave:Anthocyanins
Delphinidin
Msn2
Petunidin
Saccharomyces cerevisiae
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spelling The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiaeJiménez-Martín, AlbertoLisa-Santamaría, PatriciaGarcía-Marino, MatildeRivas-Gonzalo, Julián C.Revuelta Doval, José LuisAnthocyaninsDelphinidinMsn2PetunidinSaccharomyces cerevisiae12 páginas, 7 figuras, 3 tablas.-- El pdf del artículo es la versión de autor.Polyphenols are considered to be responsible for some of the health benefits derived from the consumption of red wine. These protective effects might probably be explained in the context of the xenohormesis theory that considers plant metabolites as interspecific chemical signals. However, the complexity of the polyphenolic constituents of different wines makes it difficult to clarify the specific contribution of polyphenols to such effects. In the present work, we fractionated the polyphenols of a red wine and evaluated the effect of each polyphenolic fraction on the growth pattern of the yeast Saccharomyces cerevisiae. We observed a different contribution of the phenolic fractions to the xenohormetic response of S. cerevisiae, the fractions that were enriched with red pigments being the most protective against oxidative insults. Moreover, we found that red wine phenolic fractions exert their biological activity through the activation of the Yap1 and Msn2 stress-responsive regulators. Above all, the anthocyanins delphinidin 3-glucoside and petunidin 3-glucoside were found to improve significantly the growth rate of S. cerevisiae in an Msn2-, Msn4-dependent manner, indicating that the stress regulators Msn2 and Msn4 participate in the xenohormetic activity of the wine polyphenols delphinidin and petunidin.This work was supported by grants BIO2008-00194 and AGL2005-07245-C03 from the Spanish Ministerio de Ciencia y Innovación. P.L.S. is recipient of an FPU predoctoral fellowship from the Spanish Ministerio de Educación y Ciencia.Peer reviewedBlackwell Publishing201220122010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/49622reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1111/j.1567-1364.2010.00679.xinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/496222026-05-22T06:33:51Z
dc.title.none.fl_str_mv The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
title The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
spellingShingle The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
Jiménez-Martín, Alberto
Anthocyanins
Delphinidin
Msn2
Petunidin
Saccharomyces cerevisiae
title_short The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
title_full The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
title_fullStr The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
title_full_unstemmed The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
title_sort The biological activity of the wine anthocyanins delphinidin and petunidin is mediated through Msn2 and Msn4 in Saccharomyces cerevisiae
dc.creator.none.fl_str_mv Jiménez-Martín, Alberto
Lisa-Santamaría, Patricia
García-Marino, Matilde
Rivas-Gonzalo, Julián C.
Revuelta Doval, José Luis
author Jiménez-Martín, Alberto
author_facet Jiménez-Martín, Alberto
Lisa-Santamaría, Patricia
García-Marino, Matilde
Rivas-Gonzalo, Julián C.
Revuelta Doval, José Luis
author_role author
author2 Lisa-Santamaría, Patricia
García-Marino, Matilde
Rivas-Gonzalo, Julián C.
Revuelta Doval, José Luis
author2_role author
author
author
author
dc.subject.none.fl_str_mv Anthocyanins
Delphinidin
Msn2
Petunidin
Saccharomyces cerevisiae
topic Anthocyanins
Delphinidin
Msn2
Petunidin
Saccharomyces cerevisiae
description 12 páginas, 7 figuras, 3 tablas.-- El pdf del artículo es la versión de autor.
publishDate 2010
dc.date.none.fl_str_mv 2010
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/49622
url http://hdl.handle.net/10261/49622
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1111/j.1567-1364.2010.00679.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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