An integrated approach to design novel therapeutic interventions for demyelinating disorders

Therapeutic strategies are often based on two general principles: interference with the pathogenic process and repair of the damaged tissues. Recent studies, however, have suggested that several pathological conditions may result from the interplay between genetic susceptibility traits and environme...

Descripción completa

Detalles Bibliográficos
Autores: Vidaurre, Oscar G., Liu, Jia, Haines, Jeffery, Sandoval, Juan, Nowakowski, Richard, Casaccia, Patrizia
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/126521
Acceso en línea:https://hdl.handle.net/2445/126521
Access Level:acceso abierto
Palabra clave:Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
id ES_997e7aee3af44d8d7de620eb7d62a007
oai_identifier_str oai:recercat.cat:2445/126521
network_acronym_str ES
network_name_str España
repository_id_str
spelling An integrated approach to design novel therapeutic interventions for demyelinating disordersVidaurre, Oscar G.Liu, JiaHaines, JefferySandoval, JuanNowakowski, RichardCasaccia, PatriziaEsclerosi múltipleEpigenèticaMultiple sclerosisEpigeneticsTherapeutic strategies are often based on two general principles: interference with the pathogenic process and repair of the damaged tissues. Recent studies, however, have suggested that several pathological conditions may result from the interplay between genetic susceptibility traits and environmental influences that, by modulating the epigenome, also affect disease onset and progression. Based on lessons from neural development, it is conceivable that new lines of preventive and possibly therapeutic intervention might be developed to modulate disease onset or decrease the severity of the symptoms. This review will discuss these concepts within the context of multiple sclerosis, the most common demyelinating disease of the central nervous system, and the leading cause of progressive neurological disability in young adults.Wiley2018201820122018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion14 p.application/pdfhttps://hdl.handle.net/2445/126521Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1111/j.1460-9568.2012.08118.xEuropean Journal of Neuroscience, 2012, vol. 35, num. 12, p. 1879-1886https://doi.org/10.1111/j.1460-9568.2012.08118.x(c) Federation of European Neuroscience Societies and John Wiley & Sons, 2012info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1265212026-05-29T05:05:01Z
dc.title.none.fl_str_mv An integrated approach to design novel therapeutic interventions for demyelinating disorders
title An integrated approach to design novel therapeutic interventions for demyelinating disorders
spellingShingle An integrated approach to design novel therapeutic interventions for demyelinating disorders
Vidaurre, Oscar G.
Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
title_short An integrated approach to design novel therapeutic interventions for demyelinating disorders
title_full An integrated approach to design novel therapeutic interventions for demyelinating disorders
title_fullStr An integrated approach to design novel therapeutic interventions for demyelinating disorders
title_full_unstemmed An integrated approach to design novel therapeutic interventions for demyelinating disorders
title_sort An integrated approach to design novel therapeutic interventions for demyelinating disorders
dc.creator.none.fl_str_mv Vidaurre, Oscar G.
Liu, Jia
Haines, Jeffery
Sandoval, Juan
Nowakowski, Richard
Casaccia, Patrizia
author Vidaurre, Oscar G.
author_facet Vidaurre, Oscar G.
Liu, Jia
Haines, Jeffery
Sandoval, Juan
Nowakowski, Richard
Casaccia, Patrizia
author_role author
author2 Liu, Jia
Haines, Jeffery
Sandoval, Juan
Nowakowski, Richard
Casaccia, Patrizia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
topic Esclerosi múltiple
Epigenètica
Multiple sclerosis
Epigenetics
description Therapeutic strategies are often based on two general principles: interference with the pathogenic process and repair of the damaged tissues. Recent studies, however, have suggested that several pathological conditions may result from the interplay between genetic susceptibility traits and environmental influences that, by modulating the epigenome, also affect disease onset and progression. Based on lessons from neural development, it is conceivable that new lines of preventive and possibly therapeutic intervention might be developed to modulate disease onset or decrease the severity of the symptoms. This review will discuss these concepts within the context of multiple sclerosis, the most common demyelinating disease of the central nervous system, and the leading cause of progressive neurological disability in young adults.
publishDate 2012
dc.date.none.fl_str_mv 2012
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126521
url https://hdl.handle.net/2445/126521
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/j.1460-9568.2012.08118.x
European Journal of Neuroscience, 2012, vol. 35, num. 12, p. 1879-1886
https://doi.org/10.1111/j.1460-9568.2012.08118.x
dc.rights.none.fl_str_mv (c) Federation of European Neuroscience Societies and John Wiley & Sons, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Federation of European Neuroscience Societies and John Wiley & Sons, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414294144155648
score 15,81155

Similares en LA Referencia