Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the brain parenchyma, gliosis and, axonal damage. The etiology is still unknown but it...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/672871 |
| Acceso en línea: | http://hdl.handle.net/10803/672871 |
| Access Level: | acceso abierto |
| Palabra clave: | Esclerosi múltiple Esclerosis múltiple Multiple sclerosis microRNAs Epigenètica Epigenética Epigenetics Líquid cefaloraquidi Líquido cefalorraquídeo Cerebrospinal fluid Biomarcadors Biomarcadores Biomarkers 575 616.8 |
| Sumario: | Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the brain parenchyma, gliosis and, axonal damage. The etiology is still unknown but it has been suggested that some epigenetic mechanisms such as microRNAs (miRNAs) are involved in the complex interaction between some genetic and environmental factors producing the pathology and the symptoms in MS. miRNAs might regulate gene expression post-transcriptionally. They also present many properties to be considered as promising biomarkers for different pathological conditions as they could be released into biological fluids. In this doctoral thesis, specific miRNA signatures in different clinical and pre- clinical forms of MS are described. Altogether, miR-21-5p, miR-20a-5p, miR-142-5p, miR-143-3p, miR-146a-5p and miR-448 are proposed as potential miRNA candidates involved in MS pathogenesis as their deregulation has been manifested in different sub-studies |
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