Seed longevity is controlled by metacaspases
Chemicals and CAS Registry Numbers adenosine triphosphatase 37289-25-1, 9000-83-3 proteinase 9001-92-7 Arabidopsis Proteins Valosin Containing Protein
| Autores: | , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/387640 |
| Acceso en línea: | http://hdl.handle.net/10261/387640 https://api.elsevier.com/content/abstract/scopus_id/85200842874 |
| Access Level: | acceso abierto |
| Palabra clave: | Genetics Plant molecular biology Plant physiology Plant sciences |
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Seed longevity is controlled by metacaspases |
| title |
Seed longevity is controlled by metacaspases |
| spellingShingle |
Seed longevity is controlled by metacaspases Liu, Chen Genetics Plant molecular biology Plant physiology Plant sciences |
| title_short |
Seed longevity is controlled by metacaspases |
| title_full |
Seed longevity is controlled by metacaspases |
| title_fullStr |
Seed longevity is controlled by metacaspases |
| title_full_unstemmed |
Seed longevity is controlled by metacaspases |
| title_sort |
Seed longevity is controlled by metacaspases |
| dc.creator.none.fl_str_mv |
Liu, Chen Hatzianestis, Ioannis H Pfirrmann, Thorsten Reza, Salim H Minina, Elena A Moazzami, Ali Stael, Simon Gutierrez-Beltran, Emilio Pitsili, Eugenia Dörmann, Peter D'Andrea, Sabine Gevaert, Kris Romero Campero, Francisco J Ding, Pingtao Nowack, Moritz K Van Breusegem, Frank Jones, Jonathan D G Bozhkov, Peter V Moschou, Panagiotis N |
| author |
Liu, Chen |
| author_facet |
Liu, Chen Hatzianestis, Ioannis H Pfirrmann, Thorsten Reza, Salim H Minina, Elena A Moazzami, Ali Stael, Simon Gutierrez-Beltran, Emilio Pitsili, Eugenia Dörmann, Peter D'Andrea, Sabine Gevaert, Kris Romero Campero, Francisco J Ding, Pingtao Nowack, Moritz K Van Breusegem, Frank Jones, Jonathan D G Bozhkov, Peter V Moschou, Panagiotis N |
| author_role |
author |
| author2 |
Hatzianestis, Ioannis H Pfirrmann, Thorsten Reza, Salim H Minina, Elena A Moazzami, Ali Stael, Simon Gutierrez-Beltran, Emilio Pitsili, Eugenia Dörmann, Peter D'Andrea, Sabine Gevaert, Kris Romero Campero, Francisco J Ding, Pingtao Nowack, Moritz K Van Breusegem, Frank Jones, Jonathan D G Bozhkov, Peter V Moschou, Panagiotis N |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Sainsbury Laboratoy Kyoto University Swedish University of Agricultural Sciences Knut and Alice Wallenberg Foundation European Research Council Biotechnology and Biological Sciences Research Council (UK) National Investment Fund of Greece Hellenic Foundation for Research and Innovation Swedish Research Council Carl Trygger Foundation European Commission European Research Council Liu, Chen [0000-0002-1604-0694] Hatzianestis, Ioannis H [0009-0009-0213-775X] Pfirrmann, Thorsten [0000-0002-9474-9535] Reza, Salim H [0000-0002-3646-3440] Minina, Elena A [0000-0002-2619-1859] Moazzami, Ali [0000-0003-0994-3972] Stael, Simon [0000-0001-8322-0428] Gutierrez Beltran, Emilio [0000-0001-7978-3164] Pitsili, Eugenia [0000-0001-9180-4650] Dörmann, Peter [0000-0002-5845-9370] D'Andrea, Sabine [0000-0001-7651-5762] Gevaert, Kris [0000-0002-4237-0283] Ding, Pingtao [0000-0001-9834-030X] Nowack, Moritz K [0000-0002-3535-6053] Van Breusegem, Frank [0000-0002-3147-0860] Jones, Jonathan D G [0000-0002-4953-261X] Bozhkov, Peter V [0000-0002-8819-3884] Moschou, Panagiotis N [0000-0001-7212-0595] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Genetics Plant molecular biology Plant physiology Plant sciences |
| topic |
Genetics Plant molecular biology Plant physiology Plant sciences |
| description |
Chemicals and CAS Registry Numbers adenosine triphosphatase 37289-25-1, 9000-83-3 proteinase 9001-92-7 Arabidopsis Proteins Valosin Containing Protein |
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2024 |
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2024 2025 2025 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/387640 https://api.elsevier.com/content/abstract/scopus_id/85200842874 |
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http://hdl.handle.net/10261/387640 https://api.elsevier.com/content/abstract/scopus_id/85200842874 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# PLANTEX, 101126019, 10.3030/101126019 (PNM) https://doi.org/10.1038/s41467-024-50848-2 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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aplication/pdf |
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Nature Publishing Group |
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Nature Publishing Group |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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1869414246716014592 |
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Seed longevity is controlled by metacaspasesLiu, ChenHatzianestis, Ioannis HPfirrmann, ThorstenReza, Salim HMinina, Elena AMoazzami, AliStael, SimonGutierrez-Beltran, EmilioPitsili, EugeniaDörmann, PeterD'Andrea, SabineGevaert, KrisRomero Campero, Francisco JDing, PingtaoNowack, Moritz KVan Breusegem, FrankJones, Jonathan D GBozhkov, Peter VMoschou, Panagiotis NGeneticsPlant molecular biologyPlant physiologyPlant sciencesChemicals and CAS Registry Numbers adenosine triphosphatase 37289-25-1, 9000-83-3 proteinase 9001-92-7 Arabidopsis Proteins Valosin Containing ProteinTo survive extreme desiccation, seeds enter a period of quiescence that can last millennia. Seed quiescence involves the accumulation of protective storage proteins and lipids through unknown adjustments in protein homeostasis (proteostasis). Here, we show that mutation of all six type-II metacaspase (MCA-II) proteases in Arabidopsis thaliana disturbs proteostasis in seeds. MCA-II mutant seeds fail to restrict the AAA ATPase CELL DIVISION CYCLE 48 (CDC48) at the endoplasmic reticulum to discard misfolded proteins, compromising seed storability. Endoplasmic reticulum (ER) localization of CDC48 relies on the MCA-IIs-dependent cleavage of PUX10 (ubiquitination regulatory X domain-containing 10), the adaptor protein responsible for titrating CDC48 to lipid droplets. PUX10 cleavage enables the shuttling of CDC48 between lipid droplets and the ER, providing an important regulatory mechanism sustaining spatiotemporal proteolysis, lipid droplet dynamics, and protein homeostasis. In turn, the removal of the PUX10 adaptor in MCA-II mutant seeds partially restores proteostasis, CDC48 localization, and lipid droplet dynamics prolonging seed lifespan. Taken together, we uncover a proteolytic module conferring seed longevity.We acknowledge Cyril Zipfel (The Sainsbury Laboratory), Ikuko Hara–Nishimura (Kyoto University), Hans Thordal–Christensen, and Hannele Tuominen (Swedish University of Agricultural Sciences) for sharing materials. This work received funding from the Knut and Alice Wallenberg Foundation 2018.0026 (PVB, PNM); EPIC–XS, Horizon 2020 programme of the European Union project number 823839 (KG, PNM); European Research Council (ERC) Starting Grant ‘R–ELEVATION’ 101039824 (P Ding); European Research Council (ERC) Consolidator Grant PLANTEX, 101126019, 10.3030/101126019 (PNM); Future Leader Fellowship from the Biotechnology and Biological Sciences Research Council (BBSRC) BB/R012172/1 (P Ding); European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship, and Innovation, Τ2ΕΔΚ–00597 under the call RESEARCH–CREATE–INNOVATE “BIOME” (PNM); European Union Horizon 2020 Marie Curie–RISE Grant PANTHEON 872969 (PNM); Hellenic Foundation of Research and Innovation Grant–Theodoros Papazoglou–Always Strive for Excellence NESTOR 1426 (PNM); Hellenic Foundation of Research and Innovation Fellowship 5947 (IHH); The Swedish Research Council (VR) 2019–04250 (PVB, PNM); Carl Trygger Foundation (CTS) 22:2025 (PVB); European Union Marie Skłodowska–Curie Action IF project 656011 (PNM); DESTINY (BOF–UGent) (SS, FVB). Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. Open access funding provided by Swedish University of Agricultural Sciences.Peer reviewedNature Publishing GroupSainsbury LaboratoyKyoto UniversitySwedish University of Agricultural SciencesKnut and Alice Wallenberg FoundationEuropean Research CouncilBiotechnology and Biological Sciences Research Council (UK)National Investment Fund of GreeceHellenic Foundation for Research and InnovationSwedish Research CouncilCarl Trygger FoundationEuropean CommissionEuropean Research CouncilLiu, Chen [0000-0002-1604-0694]Hatzianestis, Ioannis H [0009-0009-0213-775X]Pfirrmann, Thorsten [0000-0002-9474-9535]Reza, Salim H [0000-0002-3646-3440]Minina, Elena A [0000-0002-2619-1859]Moazzami, Ali [0000-0003-0994-3972]Stael, Simon [0000-0001-8322-0428]Gutierrez Beltran, Emilio [0000-0001-7978-3164]Pitsili, Eugenia [0000-0001-9180-4650]Dörmann, Peter [0000-0002-5845-9370]D'Andrea, Sabine [0000-0001-7651-5762]Gevaert, Kris [0000-0002-4237-0283]Ding, Pingtao [0000-0001-9834-030X]Nowack, Moritz K [0000-0002-3535-6053]Van Breusegem, Frank [0000-0002-3147-0860]Jones, Jonathan D G [0000-0002-4953-261X]Bozhkov, Peter V [0000-0002-8819-3884]Moschou, Panagiotis N [0000-0001-7212-0595]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionaplication/pdfhttp://hdl.handle.net/10261/387640https://api.elsevier.com/content/abstract/scopus_id/85200842874reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#PLANTEX, 101126019, 10.3030/101126019 (PNM)https://doi.org/10.1038/s41467-024-50848-2Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3876402026-05-22T06:33:51Z |
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15.811543 |