Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.

ABSTRACT: Despite encapsulation of drugs claim to improve the therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targeted devices, aimed at increasing the drug effect eithe...

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Detalles Bibliográficos
Autores: Castillo, Rafael R., Lozano Borregón, Daniel, Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12254
Acceso en línea:https://hdl.handle.net/20.500.14352/12254
Access Level:acceso abierto
Palabra clave:615.46
546
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
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spelling Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.Castillo, Rafael R.Lozano Borregón, DanielVallet Regí, María Dulce Nombre615.46546MaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química InorgánicaABSTRACT: Despite encapsulation of drugs claim to improve the therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targeted devices, aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, there has been designed a two-drug delivery system with dual cell-organelle targeting based on Mesoporous Silica Nanoparticles, known to be able to host drugs within their pores. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug delivery nanodevices against difficult-to-treat cancers.American Chemical SocietyUniversidad Complutense de Madrid20182018-10-0120182018-10-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12254reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/122542026-06-02T12:44:21Z
dc.title.none.fl_str_mv Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
title Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
spellingShingle Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
Castillo, Rafael R.
615.46
546
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
title_short Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
title_full Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
title_fullStr Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
title_full_unstemmed Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
title_sort Building Block Based Construction of Membrane-Organelle Double Targeted Nanosystem for Two-Drug Delivery.
dc.creator.none.fl_str_mv Castillo, Rafael R.
Lozano Borregón, Daniel
Vallet Regí, María Dulce Nombre
author Castillo, Rafael R.
author_facet Castillo, Rafael R.
Lozano Borregón, Daniel
Vallet Regí, María Dulce Nombre
author_role author
author2 Lozano Borregón, Daniel
Vallet Regí, María Dulce Nombre
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.46
546
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
topic 615.46
546
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
description ABSTRACT: Despite encapsulation of drugs claim to improve the therapeutic profile of free drugs, there are still important limitations in drug delivery. Focusing on cancer treatment, two promising implementations are combination therapy and targeted devices, aimed at increasing the drug effect either by achieving higher cell death rates or by discriminating between cell populations. However, for the time being, the scope of combining both approaches is unknown. To advance this knowledge, there has been designed a two-drug delivery system with dual cell-organelle targeting based on Mesoporous Silica Nanoparticles, known to be able to host drugs within their pores. In vitro results show a synergistic effect and high efficacy, demonstrating that the combination of dual therapy and targeting could still advance the development of drug delivery nanodevices against difficult-to-treat cancers.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-10-01
2018
2018-10-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12254
url https://hdl.handle.net/20.500.14352/12254
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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