Micron-sized DNA-gelatin coacervates generated by ionic complexation in the presence of a nonionic polysaccharide
DNA-protein coacervate microparticles can be formed via ionic complexation between DNA and a protein, facilitated by the presence of a nonionic polymer. Despite recent advances in understanding membraneless organelles (MLOs) in eukaryotic cells, their formation through liquid-liquid phase separation...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/418816 |
| Acceso en línea: | http://hdl.handle.net/10261/418816 https://api.elsevier.com/content/abstract/scopus_id/105029603432 |
| Access Level: | acceso abierto |
| Palabra clave: | Microgels Coacervates DNA Dextran Gelatin Liquid-liquid phase separation http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/9 Ensure healthy lives and promote well-being for all at all ages Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation |
| Sumario: | DNA-protein coacervate microparticles can be formed via ionic complexation between DNA and a protein, facilitated by the presence of a nonionic polymer. Despite recent advances in understanding membraneless organelles (MLOs) in eukaryotic cells, their formation through liquid-liquid phase separation remains incompletely elucidated. We hypothesized that due to their opposite charges, DNA and gelatin readily form micron-sized coacervates, and particle formation is facilitated by adding a polymer immiscible with gelatin. |
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